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Li D, Xu S, Wang Y, et al. Pharmacokinetics and drug-drug interaction between enalapril, enalaprilat and felodipine extended release (ER) in healthy subjects. Oncotarget. 2017;8(41):70752-70760doi: 10.18632/oncotarget.19984.
Li, D., Xu, S., Wang, Y., Li, D., Li, X., Pan, J., & Xu, P. (2017). Pharmacokinetics and drug-drug interaction between enalapril, enalaprilat and felodipine extended release (ER) in healthy subjects. Oncotarget, 8(41), 70752-70760. https://doi.org/10.18632/oncotarget.19984
Li, Dai, et al. "Pharmacokinetics and drug-drug interaction between enalapril, enalaprilat and felodipine extended release (ER) in healthy subjects." Oncotarget vol. 8,41 (2017): 70752-70760. doi: https://doi.org/10.18632/oncotarget.19984
Li D, Xu S, Wang Y, Li D, Li X, Pan J, Xu P. Pharmacokinetics and drug-drug interaction between enalapril, enalaprilat and felodipine extended release (ER) in healthy subjects. Oncotarget. 2017 Aug 07;8(41):70752-70760. doi: 10.18632/oncotarget.19984. eCollection 2017 Sep 19. PMID: 29050316; PMCID: PMC5642591.
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Oncotarget. 2017 Aug 07;8(41):70752-70760. doi: 10.18632/oncotarget.19984. eCollection 2017 Sep 19.

Pharmacokinetics and drug-drug interaction between enalapril, enalaprilat and felodipine extended release (ER) in healthy subjects.

Oncotarget

Dai Li, Sumei Xu, Yulu Wang, Dan Li, Xiaomin Li, Jing Pan, Pingsheng Xu

Affiliations

  1. National Institution of Drug Clinical Trial, Xiangya Hospital, Central South University, Changsha 410008, China.
  2. Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China.

PMID: 29050316 PMCID: PMC5642591 DOI: 10.18632/oncotarget.19984

Abstract

Since angiotensin-converting enzyme (ACE) inhibitors and calcium antagonists have complimentary mechanisms of action, enalapril, an ACE inhibitor, is used in combination with felodipine, a vascular selective dihydropyridine calcium antagonist, for the treatment of hypertension. The present study was designed to investigate the possible drug-drug interaction between these two agents in Chinese healthy subjects. A randomized, open-label, multiple-dose, 3-treatment, 3-period, 6-sequence cross-over study enrolling 12 healthy subjects (six male and six female subjects) was performed. Plasma pharmacokinetic studies were performed after 5 mg of enalapril and 5 mg of felodipine were administered alone or concomitantly twice per day for six days, and once in the morning of day seven. All 12 healthy subjects (mean [SD] age, 24.3 [2.8] years; body weight, 57.3 [5.7] kg; height, 163.2 [5.2] cm) completed all scheduled pharmacokinetic studies. Geometric mean ratios (with 90% CIs) of AUC

Keywords: enalapril; enalaprilat; felodipine; interaction; pharmacokinetics

Conflict of interest statement

CONFLICTS OF INTEREST The authors claim that no conflicts of interest exist.

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