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Ibáñez CA, Erthal RP, Ogo FM, et al. A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise. Front Physiol. 2017;8:807doi: 10.3389/fphys.2017.00807.
Ibáñez, C. A., Erthal, R. P., Ogo, F. M., Peres, M. N. C., Vieira, H. R., Conejo, C., Tófolo, L. P., Francisco, F. A., da Silva Silveira, S., Malta, A., Pavanello, A., Martins, I. P., da Silva, P. H. O., Jacinto Saavedra, L. P., Gonçalves, G. D., Moreira, V. M., Alves, V. S., da Silva Franco, C. C., Previate, C., Gomes, R. M., de Oliveira Venci, R., Dias, F. R. S., Armitage, J. A., Zambrano, E., Mathias, P. C. F., Fernandes, G. S. A., & Palma-Rigo, K. (2017). A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise. Frontiers in physiology, 8807. https://doi.org/10.3389/fphys.2017.00807
Ibáñez, Carlos A, et al. "A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise." Frontiers in physiology vol. 8 (2017): 807. doi: https://doi.org/10.3389/fphys.2017.00807
Ibáñez CA, Erthal RP, Ogo FM, Peres MNC, Vieira HR, Conejo C, Tófolo LP, Francisco FA, da Silva Silveira S, Malta A, Pavanello A, Martins IP, da Silva PHO, Jacinto Saavedra LP, Gonçalves GD, Moreira VM, Alves VS, da Silva Franco CC, Previate C, Gomes RM, de Oliveira Venci R, Dias FRS, Armitage JA, Zambrano E, Mathias PCF, Fernandes GSA, Palma-Rigo K. A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise. Front Physiol. 2017 Nov 02;8:807. doi: 10.3389/fphys.2017.00807. eCollection 2017. PMID: 29163186; PMCID: PMC5673641.
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Front Physiol. 2017 Nov 02;8:807. doi: 10.3389/fphys.2017.00807. eCollection 2017.

A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise.

Frontiers in physiology

Carlos A Ibáñez, Rafaela P Erthal, Fernanda M Ogo, Maria N C Peres, Henrique R Vieira, Camila Conejo, Laize P Tófolo, Flávio A Francisco, Sandra da Silva Silveira, Ananda Malta, Audrei Pavanello, Isabela P Martins, Paulo H O da Silva, Lucas Paulo Jacinto Saavedra, Gessica D Gonçalves, Veridiana M Moreira, Vander S Alves, Claudinéia C da Silva Franco, Carina Previate, Rodrigo M Gomes, Renan de Oliveira Venci, Francielle R S Dias, James A Armitage, Elena Zambrano, Paulo C F Mathias, Glaura S A Fernandes, Kesia Palma-Rigo

Affiliations

  1. Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  2. Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, Universidade Estadual de Maringá, Maringá, Brazil.
  3. Laboratory of Toxicology and Reproductive Metabolic Disorders, Department of General Biology, Universidade Estadual de Londrina, Londrina, Brazil.
  4. Laboratory of Endocrinology and Metabolism, Department of Physiological Sciences, Universidade Federal de Goiás, Goiânia, Brazil.
  5. School of Medicine, Deakin University, Waurn Ponds, VIC, Australia.

PMID: 29163186 PMCID: PMC5673641 DOI: 10.3389/fphys.2017.00807

Abstract

An interaction between obesity, impaired glucose metabolism and sperm function in adults has been observed but it is not known whether exposure to a diet high in fat during the peri-pubertal period can have longstanding programmed effects on reproductive function and gonadal structure. This study examined metabolic and reproductive function in obese rats programmed by exposure to a high fat (HF) diet during adolescence. The effect of physical training (Ex) in ameliorating this phenotype was also assessed. Thirty-day-old male Wistar rats were fed a HF diet (35% lard w/w) for 30 days then subsequently fed a normal fat diet (NF) for a 40-day recovery period. Control animals were fed a NF diet throughout life. At 70 days of life, animals started a low frequency moderate exercise training that lasted 30 days. Control animals remained sedentary (Se). At 100 days of life, biometric, metabolic and reproductive parameters were evaluated. Animals exposed to HF diet showed greater body weight, glucose intolerance, increased fat tissue deposition, reduced VO

Keywords: glucose metabolism; high fat diet; moderate exercise; obesity; reproductive system

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