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Sun J, Shi J, Huang B, et al. The degree of hepatic arterial blood supply of portal vein tumor thrombus in patients with hepatocellular carcinoma and its impact on overall survival after transarterial chemoembolization. Oncotarget. 2017;8(45):79816-79824doi: 10.18632/oncotarget.19767.
Sun, J., Shi, J., Huang, B., Cheng, F., Guo, W., Lau, W. Y., & Cheng, S. (2017). The degree of hepatic arterial blood supply of portal vein tumor thrombus in patients with hepatocellular carcinoma and its impact on overall survival after transarterial chemoembolization. Oncotarget, 8(45), 79816-79824. https://doi.org/10.18632/oncotarget.19767
Sun, Juxian, et al. "The degree of hepatic arterial blood supply of portal vein tumor thrombus in patients with hepatocellular carcinoma and its impact on overall survival after transarterial chemoembolization." Oncotarget vol. 8,45 (2017): 79816-79824. doi: https://doi.org/10.18632/oncotarget.19767
Sun J, Shi J, Huang B, Cheng F, Guo W, Lau WY, Cheng S. The degree of hepatic arterial blood supply of portal vein tumor thrombus in patients with hepatocellular carcinoma and its impact on overall survival after transarterial chemoembolization. Oncotarget. 2017 Aug 01;8(45):79816-79824. doi: 10.18632/oncotarget.19767. eCollection 2017 Oct 03. PMID: 29108363; PMCID: PMC5668096.
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Oncotarget. 2017 Aug 01;8(45):79816-79824. doi: 10.18632/oncotarget.19767. eCollection 2017 Oct 03.

The degree of hepatic arterial blood supply of portal vein tumor thrombus in patients with hepatocellular carcinoma and its impact on overall survival after transarterial chemoembolization.

Oncotarget

Juxian Sun, Jie Shi, Bin Huang, Fantian Cheng, Weixing Guo, Wan Yee Lau, Shuqun Cheng

Affiliations

  1. Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
  2. Department of Imaging, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
  3. Department of Hepatopancreatobiliary Surgery I, The Central Hospital of Wuhan, Tongji Medical University of Science and Technology, Wuhan, China.
  4. Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

PMID: 29108363 PMCID: PMC5668096 DOI: 10.18632/oncotarget.19767

Abstract

PURPOSE: To investigate the degree of arterial blood supply of portal vein tumor thrombus (PVTT) in patients with hepatocellular carcinoma (HCC), and to evaluate its impact on overall survival after transarterial chemoembolization using lipiodol +/- gelatin sponge particles (TACE).

RESULTS: Of the 10 patients who underwent surgery, the number of patients with good/mild/poor staining of PVTT by methylene blue were 3, 4, and 3, respectively. The degrees of methylene blue staining in these patients correlated well with the degrees of accumulation of lipiodol in PVTT in these patients, i.e. good/mild/poor in 3, 4, and 3 patients, respectively. For the 77 patients who underwent TACE as treatment, they were divided into 2 groups: good accumulation of lipiodol (

PATIENTS AND METHODS: Patients with HCC with PVTT who underwent surgical resection received preoperative TACE. At operation, arterial injection of methylene blue into the common hepatic artery was carried out. During the study period, other patients with unresectable HCC with PVTT were treated with TACE.

CONCLUSION: In about 1/3 of patients with HCC with PVTT, the arterial blood supply from the hepatic artery to the PVTT was good. These patients responded better to TACE than those patients with mild/poor arterial supply.

Keywords: TACE; blood supply; hepatocellular carcinoma; portal vein tumor thrombus

Conflict of interest statement

CONFLICTS OF INTEREST No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.

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