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Liu H, Li B, Yu X, et al. Preoperative risk factors for massive blood loss in adrenalectomy for pheochromocytoma. Oncotarget. 2017;8(45):79964-79970doi: 10.18632/oncotarget.20396.
Liu, H., Li, B., Yu, X., & Huang, Y. (2017). Preoperative risk factors for massive blood loss in adrenalectomy for pheochromocytoma. Oncotarget, 8(45), 79964-79970. https://doi.org/10.18632/oncotarget.20396
Liu, Hongju, et al. "Preoperative risk factors for massive blood loss in adrenalectomy for pheochromocytoma." Oncotarget vol. 8,45 (2017): 79964-79970. doi: https://doi.org/10.18632/oncotarget.20396
Liu H, Li B, Yu X, Huang Y. Preoperative risk factors for massive blood loss in adrenalectomy for pheochromocytoma. Oncotarget. 2017 Aug 22;8(45):79964-79970. doi: 10.18632/oncotarget.20396. eCollection 2017 Oct 03. PMID: 29108378; PMCID: PMC5668111.
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Oncotarget. 2017 Aug 22;8(45):79964-79970. doi: 10.18632/oncotarget.20396. eCollection 2017 Oct 03.

Preoperative risk factors for massive blood loss in adrenalectomy for pheochromocytoma.

Oncotarget

Hongju Liu, Bin Li, Xuerong Yu, Yuguang Huang

Affiliations

  1. Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China.
  2. Department of Anesthesiology, Jiujiang Maternal and Child Care Centres, Jiangxi, China.

PMID: 29108378 PMCID: PMC5668111 DOI: 10.18632/oncotarget.20396

Abstract

BACKGROUND: This retrospective analysis of patients who underwent adrenalectomy for pheochromocytoma aimed to determine preoperative risk factors for intraoperative massive blood loss. Preoperative identification of patients at high-risk of massive blood loss may be helpful in anesthesia management and preoperative preparation.

MATERIALS AND METHODS: The study involved data of 268 patients who had undergone pheochromocytoma surgery at the Peking Union Medical College Hospital between January 1, 2013 and October 31, 2016. For analysis, the patients were grouped according to intraoperative blood loss: ≥ 20% of estimated blood volume (group A,

RESULTS: The two groups showed significant differences in tumor location, tumor size, operative approach, preoperative 24-hour urine level of total noradrenaline, preoperative hemoglobin concentration, phenoxybenzamine maximum daily dose, preoperative preparation time, intraoperative urine volume, crystalloid and colloidal fluid volumes, allogeneic red blood cell transfusion, plasma and autologous blood transfusion volumes, incidence of prolonged hypotension, postoperative drainage volume, lowest and discharge hemoglobin concentrations, length of stay in intensive care unit and length of postoperative hospitalization. Binary logistic regression analysis indicated increased risk of intraoperative massive blood loss in subjects with tumors proximal to vessels or other organs (odds ratio (OR): 4.227), with tumors ≥ 5 cm (OR: 7.321), or with preoperative preparation time of ≤ 14 days (OR: 17.747).

CONCLUSIONS: Tumors proximal to vessels and other organs or with maximum diameter of ≥ 5 cm (as shown by preoperative radiographic evidence), and preoperative preparation time of ≤ 14 days were independent risk factors of intraoperative massive blood loss in patients treated with adrenalectomy for pheochromocytoma.

Keywords: adrenalectomy; massive blood loss; pheochromocytoma; risk factors

Conflict of interest statement

CONFLICTS OF INTEREST The authors have no conflicts of interest to declare.

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