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Grosche L, Kummer M, Steinkasserer A. What Goes Around, Comes Around - HSV-1 Replication in Monocyte-Derived Dendritic Cells. Front Microbiol. 2017;8:2149doi: 10.3389/fmicb.2017.02149.
Grosche, L., Kummer, M., & Steinkasserer, A. (2017). What Goes Around, Comes Around - HSV-1 Replication in Monocyte-Derived Dendritic Cells. Frontiers in microbiology, 82149. https://doi.org/10.3389/fmicb.2017.02149
Grosche, Linda, et al. "What Goes Around, Comes Around - HSV-1 Replication in Monocyte-Derived Dendritic Cells." Frontiers in microbiology vol. 8 (2017): 2149. doi: https://doi.org/10.3389/fmicb.2017.02149
Grosche L, Kummer M, Steinkasserer A. What Goes Around, Comes Around - HSV-1 Replication in Monocyte-Derived Dendritic Cells. Front Microbiol. 2017 Nov 07;8:2149. doi: 10.3389/fmicb.2017.02149. eCollection 2017. PMID: 29163433; PMCID: PMC5674004.
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Front Microbiol. 2017 Nov 07;8:2149. doi: 10.3389/fmicb.2017.02149. eCollection 2017.

What Goes Around, Comes Around - HSV-1 Replication in Monocyte-Derived Dendritic Cells.

Frontiers in microbiology

Linda Grosche, Mirko Kummer, Alexander Steinkasserer

Affiliations

  1. Department of Immune Modulation, University Hospital Erlangen, Erlangen, Germany.

PMID: 29163433 PMCID: PMC5674004 DOI: 10.3389/fmicb.2017.02149

Abstract

HSV-1 is a very successful human pathogen, known for its high sero-prevalence and the ability to infect a wide range of different cell types, including dendritic cells (DCs). As very potent antigen-presenting cells DCs play an important role in the induction of antiviral immune responses and therefore represent a strategic target for viral-mediated immune escape mechanisms. It is known that HSV-1 completes its gene expression profile in immature as well as in mature DCs, while lytic infection is only found in immature DCs (iDCs). Notably, HSV-1 infected mature DCs (mDCs) fail to release infectious progeny virions into the supernatant. Apart from HSV-1 dissemination via extracellular routes cell-to-cell spread counteracts a yet unknown mechanism by which the virus is trapped in mDCs and not released into the supernatant. The dissemination in a cell-cell contact-dependent manner enables HSV-1 to infect bystander cells without the exposure toward the extracellular environment. This supports the virus to successfully infect the host and establish latency. In this review the mechanism of HSV-1 replication in iDCs and mDCs and its immunological as well as virological implications, will be discussed.

Keywords: HSV-1; cell-to-cell spread; dendritic cells; replication

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