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Park GC, Kim JM, Park HY, et al. TSH-independent release of thyroid hormones through cold exposure in aging rats. Oncotarget. 2017;8(52):89431-89438doi: 10.18632/oncotarget.19851.
Park, G. C., Kim, J. M., Park, H. Y., Han, J. M., Shin, S. C., Jang, J. Y., Jung, D., Kim, I. J., Lee, J. C., & Lee, B. J. (2017). TSH-independent release of thyroid hormones through cold exposure in aging rats. Oncotarget, 8(52), 89431-89438. https://doi.org/10.18632/oncotarget.19851
Park, Gi Cheol, et al. "TSH-independent release of thyroid hormones through cold exposure in aging rats." Oncotarget vol. 8,52 (2017): 89431-89438. doi: https://doi.org/10.18632/oncotarget.19851
Park GC, Kim JM, Park HY, Han JM, Shin SC, Jang JY, Jung D, Kim IJ, Lee JC, Lee BJ. TSH-independent release of thyroid hormones through cold exposure in aging rats. Oncotarget. 2017 Aug 03;8(52):89431-89438. doi: 10.18632/oncotarget.19851. eCollection 2017 Oct 27. PMID: 29163760; PMCID: PMC5685681.
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Oncotarget. 2017 Aug 03;8(52):89431-89438. doi: 10.18632/oncotarget.19851. eCollection 2017 Oct 27.

TSH-independent release of thyroid hormones through cold exposure in aging rats.

Oncotarget

Gi Cheol Park, Ji Min Kim, Hee-Young Park, Ji Min Han, Sung-Chan Shin, Jeon Yeob Jang, Dawoon Jung, In Joo Kim, Jin-Choon Lee, Byung-Joo Lee

Affiliations

  1. Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  2. Department of Otorhinolaryngology - Head and Neck Surgery, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
  3. Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  4. Department of Otorhinolaryngology - Head and Neck Surgery, Ajou University School of Medicine, Suwon, Korea.
  5. Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
  6. Department of Otorhinolaryngology - Head and Neck Surgery, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Yangsan Hospital, Yangsan, Gyeongnam, Korea.

PMID: 29163760 PMCID: PMC5685681 DOI: 10.18632/oncotarget.19851

Abstract

Thyroid function decreases and cold exposure response becomes impaired with increasing age. We investigated the age-related changes in thyroid structure and function and cold-induced changes in the thyroid activity of aging rats. Thirty-two male Sprague-Dawley rats were randomly divided into four groups (8 rats per group): young (7 months) and old (22 months) groups exposed to room temperature and cold stress. The active follicle ratio and serum free T3, T4 and TSH, and TSH receptor (TSHR) concentrations in the thyroid tissues of the rats from each group were compared. At room temperature, old rats had significantly lower active follicle ratio and free T3 and T4 concentrations than young rats. Furthermore, old rats displayed higher TSH level than young. Exposure to cold temperature led to significantly increased active colloid ratio and free T3 and T4 concentrations among old rats, but no significant differences were found among young rats. Additionally, no significant changes in the TSH and TSHR levels were observed after cold exposure in both young and old rats. Old rats have lower thyroid function than young rats under normal temperature. Aging rats are more susceptible to cold stress than young rats, and cold-induced thyroid activation occurs independently of TSH. We investigated the age-related changes in the thyroid structure and function and cold-induced changes in the thyroid activity of aging rats. Aging rats have structurally less active thyroid follicles and functionally lower thyroid hormone levels than young rats. Furthermore, old rats are more susceptible to cold stress than young rats, and cold-induced thyroid activation occurs independently of TSH.

Keywords: Gerotarget; aging; cold exposure; rat; thyroid

Conflict of interest statement

CONFLICTS OF INTEREST The authors have no conflict of interests to declare.

References

  1. Am J Physiol. 1950 Oct;163(1):81-91 - PubMed
  2. Exp Biol Med (Maywood). 2001 Jun;226(6):552-8 - PubMed
  3. J Clin Invest. 2001 Jul;108(1):35-7 - PubMed
  4. Clin Endocrinol Metab. 1984 Nov;13(3):581-95 - PubMed
  5. Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R103-8 - PubMed
  6. J Clin Endocrinol Metab. 2010 Feb;95(2):496-502 - PubMed
  7. J Pharmacol Toxicol Methods. 1998 Nov;40(4):201-5 - PubMed
  8. J Microsc. 1972 Apr;95(2):345-8 - PubMed
  9. Thyroid. 2008 Feb;18(2):157-65 - PubMed
  10. J Appl Physiol (1985). 1985 Jan;58(1):180-6 - PubMed
  11. Am J Med. 1982 Jul;73(1):41-8 - PubMed
  12. Tissue Cell. 2003 Jun;35(3):223-31 - PubMed
  13. J Appl Physiol. 1974 Oct;37(4):562-5 - PubMed
  14. Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R99-102 - PubMed
  15. Endocrinology. 1986 Sep;119(3):1058-62 - PubMed
  16. J Pathol. 2007 Jan;211(2):173-80 - PubMed
  17. Curr Opin Endocrinol Diabetes Obes. 2013 Oct;20(5):455-9 - PubMed
  18. Thyroid. 1995 Dec;5(6):481-92 - PubMed
  19. Nat Med. 2010 Sep;16(9):965-7 - PubMed
  20. Endocrinology. 2016 Feb;157(2):455-62 - PubMed
  21. Crit Care Med. 2009 Jul;37(7 Suppl):S203-10 - PubMed
  22. Thyroid Res. 2012 Aug 16;5(1):7 - PubMed
  23. J Clin Endocrinol Metab. 2012 May;97(5):1554-62 - PubMed
  24. Environ Health Perspect. 1977 Oct;20:127-30 - PubMed
  25. Mol Cell Endocrinol. 2003 Jul 31;205(1-2):65-77 - PubMed
  26. Prog Clin Biol Res. 1981;59B:151-60 - PubMed
  27. J Gerontol A Biol Sci Med Sci. 2009 Apr;64(4):443-51 - PubMed
  28. J Appl Physiol. 1955 Sep;8(2):145-8 - PubMed
  29. Am J Physiol Endocrinol Metab. 2005 May;288(5):E861-7 - PubMed
  30. Physiol Rev. 2006 Apr;86(2):435-64 - PubMed
  31. Clin Endocrinol (Oxf). 2012 Nov;77(5):773-9 - PubMed
  32. Acta Histochem Suppl. 1989;37:191-8 - PubMed

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