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Chen AC, Xi Y, Carroll M, et al. Cytokine responses to two common respiratory pathogens in children are dependent on interleukin-1β. ERJ Open Res. 2017;3(4)doi: 10.1183/23120541.00025-2017.
Chen, A. C., Xi, Y., Carroll, M., Petsky, H. L., Gardiner, S. J., Pizzutto, S. J., Yerkovich, S. T., Baines, K. J., Gibson, P. G., Hodge, S., Masters, I. B., Buntain, H. M., Chang, A. B., & Upham, J. W. (2017). Cytokine responses to two common respiratory pathogens in children are dependent on interleukin-1β. ERJ open research, 3(4), . https://doi.org/10.1183/23120541.00025-2017
Chen, Alice C-H, et al. "Cytokine responses to two common respiratory pathogens in children are dependent on interleukin-1β." ERJ open research vol. 3,4 (2017). doi: https://doi.org/10.1183/23120541.00025-2017
Chen AC, Xi Y, Carroll M, Petsky HL, Gardiner SJ, Pizzutto SJ, Yerkovich ST, Baines KJ, Gibson PG, Hodge S, Masters IB, Buntain HM, Chang AB, Upham JW. Cytokine responses to two common respiratory pathogens in children are dependent on interleukin-1β. ERJ Open Res. 2017 Oct 02;3(4). doi: 10.1183/23120541.00025-2017. eCollection 2017 Oct. PMID: 29204435; PMCID: PMC5703357.
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ERJ Open Res. 2017 Oct 02;3(4). doi: 10.1183/23120541.00025-2017. eCollection 2017 Oct.

Cytokine responses to two common respiratory pathogens in children are dependent on interleukin-1β.

ERJ open research

Alice C-H Chen, Yang Xi, Melanie Carroll, Helen L Petsky, Samantha J Gardiner, Susan J Pizzutto, Stephanie T Yerkovich, Katherine J Baines, Peter G Gibson, Sandra Hodge, Ian B Masters, Helen M Buntain, Anne B Chang, John W Upham

Affiliations

  1. Diamantina Institute, The University of Queensland, Brisbane, Australia.
  2. These authors contributed equally.
  3. Queensland University of Technology, CCHR, Brisbane, Australia.
  4. Child Health Division, Menzies School of Health Research, Charles Darwin Hospital, Darwin, Australia.
  5. The Prince Charles Hospital, Brisbane, Australia.
  6. The University of Newcastle, Newcastle, Australia.
  7. Hanson Institute, Adelaide, Australia.
  8. Respiratory and Sleep Medicine, Lady Cilento Children's Hospital, Brisbane, Australia.
  9. Wesley Hospital, Brisbane, Australia.

PMID: 29204435 PMCID: PMC5703357 DOI: 10.1183/23120541.00025-2017

Abstract

Protracted bacterial bronchitis (PBB) in young children is a common cause of prolonged wet cough and may be a precursor to bronchiectasis in some children. Although PBB and bronchiectasis are both characterised by neutrophilic airway inflammation and a prominent interleukin (IL)-1β signature, the contribution of the IL-1β pathway to host defence is not clear. This study aimed to compare systemic immune responses against common pathogens in children with PBB, bronchiectasis and control children and to determine the importance of the IL-1β pathway. Non-typeable

Conflict of interest statement

Conflict of interest: Disclosures can be found alongside this article at openres.ersjournals.com

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