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Carlisi CO, Norman L, Murphy CM, et al. Disorder-Specific and Shared Brain Abnormalities During Vigilance in Autism and Obsessive-Compulsive Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017;2(8):644-654doi: 10.1016/j.bpsc.2016.12.005.
Carlisi, C. O., Norman, L., Murphy, C. M., Christakou, A., Chantiluke, K., Giampietro, V., Simmons, A., Brammer, M., Murphy, D. G., Mataix-Cols, D., & Rubia, K. (2017). Disorder-Specific and Shared Brain Abnormalities During Vigilance in Autism and Obsessive-Compulsive Disorder. Biological psychiatry. Cognitive neuroscience and neuroimaging, 2(8), 644-654. https://doi.org/10.1016/j.bpsc.2016.12.005
Carlisi, Christina O, et al. "Disorder-Specific and Shared Brain Abnormalities During Vigilance in Autism and Obsessive-Compulsive Disorder." Biological psychiatry. Cognitive neuroscience and neuroimaging vol. 2,8 (2017): 644-654. doi: https://doi.org/10.1016/j.bpsc.2016.12.005
Carlisi CO, Norman L, Murphy CM, Christakou A, Chantiluke K, Giampietro V, Simmons A, Brammer M, Murphy DG, Mataix-Cols D, Rubia K. Disorder-Specific and Shared Brain Abnormalities During Vigilance in Autism and Obsessive-Compulsive Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Nov;2(8):644-654. doi: 10.1016/j.bpsc.2016.12.005. PMID: 29167833; PMCID: PMC5685008.
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Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Nov;2(8):644-654. doi: 10.1016/j.bpsc.2016.12.005.

Disorder-Specific and Shared Brain Abnormalities During Vigilance in Autism and Obsessive-Compulsive Disorder.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Christina O Carlisi, Luke Norman, Clodagh M Murphy, Anastasia Christakou, Kaylita Chantiluke, Vincent Giampietro, Andrew Simmons, Michael Brammer, Declan G Murphy, David Mataix-Cols, Katya Rubia

Affiliations

  1. Department of Child and Adolescent Psychiatry, Sackler Institute for Translational Neurodevelopmental Sciences, London.
  2. Department of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopmental Sciences, Psychology and Neuroscience, King's College, London.
  3. Behavioural Genetics Clinic, Adult Autism Service, Behavioural and Developmental Psychiatry Clinical Academic Group, South London and Maudsley NHS Foundation Trust, London.
  4. Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom.
  5. Department of Neuroimaging, Psychology and Neuroscience, King's College, London.
  6. National Institute for Health Research Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience, King's College, London.
  7. Department of Neurobiology, Care Sciences and Society (AS), Center for Alzheimer Research, Division of Clinical Geriatrics, Stockholm, Sweden.
  8. Department of Clinical Neuroscience(DM-C), Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.

PMID: 29167833 PMCID: PMC5685008 DOI: 10.1016/j.bpsc.2016.12.005

Abstract

BACKGROUND: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) are often comorbid and share similarities across some cognitive phenotypes, including certain aspects of attention. However, no functional magnetic resonance imaging studies have compared the underlying neural mechanisms contributing to these shared phenotypes.

METHODS: Age- and IQ-matched boys (11-17 years old) with ASD (

RESULTS: Whereas boys with ASD and OCD were not impaired on task performance, there was a significant group by attention load interaction in several brain regions. With increasing attention load, left inferior frontal cortex/insula and left inferior parietal lobe/pre/post-central gyrus were progressively less activated in boys with OCD relative to the other two groups. In addition, boys with OCD showed progressively increased activation with increasing attention load in rostromedial prefrontal/anterior cingulate cortex relative to boys with ASD and control boys. Shared neurofunctional abnormalities between boys with ASD and boys with OCD included increased activation with increasing attention load in cerebellum and occipital regions, possibly reflecting increased default mode network activation.

CONCLUSIONS: This first functional magnetic resonance imaging study to compare boys with ASD and OCD showed shared abnormalities in posterior cerebellar-occipital brain regions. However, boys with OCD showed a disorder-specific pattern of reduced activation in left inferior frontal and temporo-parietal regions but increased activation of medial frontal regions, which may potentially be related to neurobiological mechanisms underlying cognitive and clinical phenotypes of OCD.

Keywords: ASD; Adolescence; Attention; OCD; Vigilance; fMRI

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