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Park SG, Choi HN, Yang HR, et al. Effects of zinc supplementation on catch-up growth in children with failure to thrive. Nutr Res Pract. 2017;11(6):487-491doi: 10.4162/nrp.2017.11.6.487.
Park, S. G., Choi, H. N., Yang, H. R., & Yim, J. E. (2017). Effects of zinc supplementation on catch-up growth in children with failure to thrive. Nutrition research and practice, 11(6), 487-491. https://doi.org/10.4162/nrp.2017.11.6.487
Park, Seul-Gi, et al. "Effects of zinc supplementation on catch-up growth in children with failure to thrive." Nutrition research and practice vol. 11,6 (2017): 487-491. doi: https://doi.org/10.4162/nrp.2017.11.6.487
Park SG, Choi HN, Yang HR, Yim JE. Effects of zinc supplementation on catch-up growth in children with failure to thrive. Nutr Res Pract. 2017 Dec;11(6):487-491. doi: 10.4162/nrp.2017.11.6.487. Epub 2017 Nov 25. PMID: 29209459; PMCID: PMC5712499.
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Nutr Res Pract. 2017 Dec;11(6):487-491. doi: 10.4162/nrp.2017.11.6.487. Epub 2017 Nov 25.

Effects of zinc supplementation on catch-up growth in children with failure to thrive.

Nutrition research and practice

Seul-Gi Park, Ha-Neul Choi, Hye-Ran Yang, Jung-Eun Yim

Affiliations

  1. Department of Food and Nutrition, Changwon National University, 20 Changwondaehak-ro, Uichang-gu, Changwon, Gyeongnam 51140, Korea.
  2. Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82 Gumi-ro, Bundang-gu, Seongnam, Gyeonggi 13620, Korea.

PMID: 29209459 PMCID: PMC5712499 DOI: 10.4162/nrp.2017.11.6.487

Abstract

BACKGROUND/OBJECTIVES: Although globally the numbers of children diagnosed with failure to thrive (FTT) have decreased, FTT is still a serious pediatric problem. We aimed to investigate the effects of zinc supplementation for 6 months on growth parameters of infants and children with FTT.

SUBJECTS/METHODS: In this retrospective study, of the 114 participants aged between 4 months and 6 years, 89 were included in the zinc supplementation group and were provided with nutrition counseling plus an oral zinc supplement for 6 months. The caregivers of the 25 participants in the control group received nutrition counseling alone. Medical data of these children, including sex, age, height, weight, serum zinc level, and serum insulin-like growth factor 1 (IGF1) level were analyzed.

RESULTS: Zinc supplementation for 6 months increased weight-for-age Z-score and serum zinc levels (5.5%) in the zinc supplementation group of underweight category children. As for stunting category, height-for-age Z-score of the participants in the zinc supplementation group increased when compared with the baseline, and serum zinc levels increased in the normal or mild stunting group. Serum IGF1 levels did not change significantly in any group. Thus, zinc supplementation was more effective in children in the underweight category than those in the stunted category; this effect differed according to the degree of the FTT.

CONCLUSION: These findings suggest that zinc supplementation may have beneficial effects for growth of infants and children with FTT, and zinc supplementation would be required according to degree of FTT.

Keywords: Failure to thrive; child; growth; zinc

Conflict of interest statement

CONFLICT OF INTEREST: The authors declare no potential conflicts of interests.

References

  1. J Pediatr Endocrinol Metab. 2009 Dec;22(12):1137-43 - PubMed
  2. J Nutr. 1990 Nov;120 Suppl 11:1474-9 - PubMed
  3. Pediatr Clin North Am. 1998 Feb;45(1):169-87 - PubMed
  4. Am Fam Physician. 2003 Sep 1;68(5):879-84 - PubMed
  5. J Clin Gastroenterol. 2002 Nov-Dec;35(5):371-4 - PubMed
  6. Am J Clin Nutr. 2002 Jun;75(6):1062-71 - PubMed
  7. Pediatr Rev. 2011 Mar;32(3):100-7; quiz 108 - PubMed
  8. Pituitary. 2007;10(2):189-203 - PubMed
  9. Paediatr Child Health. 2012 Oct;17(8):447-54 - PubMed
  10. Pediatr Rev. 1992 Dec;13(12):453-60 - PubMed
  11. Adv Nutr. 2013 Mar 01;4(2):176-90 - PubMed
  12. Food Nutr Bull. 2009 Mar;30(1 Suppl):S60-78 - PubMed
  13. PLoS One. 2013 Nov 06;8(11):e80115 - PubMed
  14. J Nutr. 1995 Apr;125(4):874-9 - PubMed
  15. Clin Pediatr (Phila). 2008 Oct;47(8):762-5 - PubMed
  16. Pediatr Rev. 1997 Nov;18(11):371-8 - PubMed
  17. Malays J Pathol. 2015 Apr;37(1):35-8 - PubMed
  18. Am Fam Physician. 2011 Apr 1;83(7):829-34 - PubMed
  19. Pediatr Gastroenterol Hepatol Nutr. 2013 Dec;16(4):261-8 - PubMed
  20. Clin Nutr. 1991 Oct;10(5):284-91 - PubMed
  21. Arch Dis Child. 2000 Jan;82(1):5-9 - PubMed
  22. J Am Coll Nutr. 2015;34(4):290-9 - PubMed

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