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Shen J, Rangel DF, Ha D, et al. New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis. Mol Cell Oncol. 2017;4(6):e1345350doi: 10.1080/23723556.2017.1345350.
Shen, J., Rangel, D. F., Ha, D., & Lee, A. S. (2017). New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis. Molecular & cellular oncology, 4(6), e1345350. https://doi.org/10.1080/23723556.2017.1345350
Shen, Jieli, et al. "New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis." Molecular & cellular oncology vol. 4,6 (2017): e1345350. doi: https://doi.org/10.1080/23723556.2017.1345350
Shen J, Rangel DF, Ha D, Lee AS. New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis. Mol Cell Oncol. 2017 Jun 30;4(6):e1345350. doi: 10.1080/23723556.2017.1345350. eCollection 2017. PMID: 29209644; PMCID: PMC5706948.
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Mol Cell Oncol. 2017 Jun 30;4(6):e1345350. doi: 10.1080/23723556.2017.1345350. eCollection 2017.

New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis.

Molecular & cellular oncology

Jieli Shen, Daisy F Rangel, Dat Ha, Amy S Lee

Affiliations

  1. Department of Biochemistry and Molecular Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

PMID: 29209644 PMCID: PMC5706948 DOI: 10.1080/23723556.2017.1345350

Abstract

Metaplasia is emerging as a key process in tumorigenesis. We discovered that 2 essential endoplasmic reticulum (ER) chaperones, 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) have a role in metaplasia. Grp78 haploinsufficiency in the mouse pancreas impairs acinar-to-ductal metaplasia, whereas in the uterus, Grp94 loss induces squamous cell metaplasia; both resulting in tumor suppression.

Keywords: ER chaperone; GRP78; GRP94; metaplasia; mouse models; pancreatic cancer

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