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Int J Womens Health. 2017 Nov 16;9:835-842. doi: 10.2147/IJWH.S139289. eCollection 2017.

Clinical behavior of a cohort of adult women with facial acne treated with combined oral contraceptive: ethinylestradiol 20 µg/dienogest 2 mg.

International journal of women's health

John Palacio-Cardona, Diana María Caicedo Borrero

Affiliations

  1. Student Welfare Service - Health Area, Santiago de Cali University.
  2. Support for Research, Academic, Scientific and Technological Services (SEACIT), Cali, Colombia.

PMID: 29180907 PMCID: PMC5695259 DOI: 10.2147/IJWH.S139289

Abstract

Acne vulgaris is the most common skin disease. It affects the young adult female population and generates great impact on physical and mental health. One of the treatments with good results for affected women is combined oral contraceptive pills (COCPs). The aim of this study was to determine the clinical effect of facial acne management with ethinylestradiol 20 µg/dienogest 2 mg in a cohort of Colombian adult women. A cohort of 120 female university students was followed for 12 months. These participants were enrolled in the Sexual and Reproductive Health Program of the Santiago de Cali University. This cohort admitted women between 18 and 30 years old who had chosen to start birth control with ethinylestradiol 20 µg/dienogest 2 mg COCPs, did not have contraindi cations to the use of COCPs, and had been diagnosed with acne. Monthly monitoring of facial acne lesion count was performed. Relative changes in facial lesion count were identified. At the end of follow-up, the percentage of reduction of lesions was 94% and 23% of women had a 100% reduction in acne lesions. In conclusion, the continued use of the ethinylestradiol 20 µg/dienogest 2 mg COCPs reduced inflammatory and non-inflammatory acne lesions in reproductive-age women between 18 and 30 years of age with no severe acne.

Keywords: acne vulgaris; contraceptive agents; female contraceptive agents; hormonal; oral; reproductive control agents; skin diseases

Conflict of interest statement

Disclosure The study sponsors were not involved in design, implementation, or analysis of project information. The authors report no conflicts of interest in this work.

References

  1. Drugs. 2003;63(5):463-92 - PubMed
  2. Br J Dermatol. 2013 Mar;168(3):474-85 - PubMed
  3. Prim Care. 2015 Dec;42(4):465-71 - PubMed
  4. J Eur Acad Dermatol Venereol. 2015 Jun;29 Suppl 5:14-9 - PubMed
  5. Eur J Obstet Gynecol Reprod Biol. 2011 Apr;155(2):171-5 - PubMed
  6. J Am Acad Dermatol. 2016 May;74(5):945-73.e33 - PubMed
  7. Cochrane Database Syst Rev. 2012 Jul 11;(7):CD004425 - PubMed
  8. Drugs. 2010 Apr 16;70(6):681-9 - PubMed
  9. Eur J Contracept Reprod Health Care. 2013 Aug;18(4):274-83 - PubMed
  10. Indian J Dermatol. 2014 May;59(3):316 - PubMed
  11. BMJ. 2013 Sep 12;347:f5298 - PubMed
  12. Drugs. 1998 Nov;56(5):825-33; discussion 834-5 - PubMed
  13. J Eur Acad Dermatol Venereol. 2013 Sep;27(9):1063-70 - PubMed
  14. Actas Dermosifiliogr. 2013 Jan;104(1):61-6 - PubMed
  15. Methods Find Exp Clin Pharmacol. 2002 Nov;24(9):585-92 - PubMed
  16. Contraception. 1996 Mar;53(3):163-70 - PubMed
  17. Br J Dermatol. 2015 Jul;172 Suppl 1:3-12 - PubMed
  18. J Eur Acad Dermatol Venereol. 2015 Jun;29 Suppl 5:1-7 - PubMed
  19. Contraception. 2009 Apr;79(4):282-9 - PubMed
  20. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD003989 - PubMed
  21. Br J Dermatol. 2015 Jul;172 Suppl 1:37-46 - PubMed
  22. BMJ. 2016 May 10;353:i2002 - PubMed
  23. J Eur Acad Dermatol Venereol. 2012 Feb;26 Suppl 1:1-29 - PubMed
  24. J Am Acad Dermatol. 2014 Sep;71(3):450-9 - PubMed

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