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Pancholi AK, Iacobini GP, Clarkson GJ, et al. Synthesis of 4,5-Diazaspiro[2.3]hexanes and 1,2-Diazaspiro[3.3]heptanes as Hexahydropyridazine Analogues. J Org Chem. 2017;83(1):491-498doi: 10.1021/acs.joc.7b02622.
Pancholi, A. K., Iacobini, G. P., Clarkson, G. J., Porter, D. W., & Shipman, M. (2018). Synthesis of 4,5-Diazaspiro[2.3]hexanes and 1,2-Diazaspiro[3.3]heptanes as Hexahydropyridazine Analogues. The Journal of organic chemistry, 83(1), 491-498. https://doi.org/10.1021/acs.joc.7b02622
Pancholi, Alpa K, et al. "Synthesis of 4,5-Diazaspiro[2.3]hexanes and 1,2-Diazaspiro[3.3]heptanes as Hexahydropyridazine Analogues." The Journal of organic chemistry vol. 83,1 (2018): 491-498. doi: https://doi.org/10.1021/acs.joc.7b02622
Pancholi AK, Iacobini GP, Clarkson GJ, Porter DW, Shipman M. Synthesis of 4,5-Diazaspiro[2.3]hexanes and 1,2-Diazaspiro[3.3]heptanes as Hexahydropyridazine Analogues. J Org Chem. 2018 Jan 05;83(1):491-498. doi: 10.1021/acs.joc.7b02622. Epub 2017 Dec 11. PMID: 29183129.
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J Org Chem. 2018 Jan 05;83(1):491-498. doi: 10.1021/acs.joc.7b02622. Epub 2017 Dec 11.

Synthesis of 4,5-Diazaspiro[2.3]hexanes and 1,2-Diazaspiro[3.3]heptanes as Hexahydropyridazine Analogues.

The Journal of organic chemistry

Alpa K Pancholi, Greg P Iacobini, Guy J Clarkson, David W Porter, Michael Shipman

Affiliations

  1. Department of Chemistry, University of Warwick , Gibbet Hill Road, Coventry, CV4 7AL, United Kingdom.
  2. Novartis Institutes for BioMedical Research, Horsham Research Centre , Wimblehurst Road, West Sussex, RH12 5AB, United Kingdom.

PMID: 29183129 DOI: 10.1021/acs.joc.7b02622

Abstract

4,5-Diazaspiro[2.3]hexanes are made by dihalocarbene addition across the exocyclic double bond of readily accessible 3-alkylidene-1,2-diazetidines. Using difluorocarbene, generated from TMSCF

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