Display options
Cite
Jacobi N, Seeboeck R, Hofmann E, et al. Organotypic three-dimensional cancer cell cultures mirror drug responses . Oncotarget. 2017;8(64):107423-107440doi: 10.18632/oncotarget.22475.
Jacobi, N., Seeboeck, R., Hofmann, E., Schweiger, H., Smolinska, V., Mohr, T., Boyer, A., Sommergruber, W., Lechner, P., Pichler-Huebschmann, C., Önder, K., Hundsberger, H., Wiesner, C., & Eger, A. (2017). Organotypic three-dimensional cancer cell cultures mirror drug responses . Oncotarget, 8(64), 107423-107440. https://doi.org/10.18632/oncotarget.22475
Jacobi, Nico, et al. "Organotypic three-dimensional cancer cell cultures mirror drug responses ." Oncotarget vol. 8,64 (2017): 107423-107440. doi: https://doi.org/10.18632/oncotarget.22475
Jacobi N, Seeboeck R, Hofmann E, Schweiger H, Smolinska V, Mohr T, Boyer A, Sommergruber W, Lechner P, Pichler-Huebschmann C, Önder K, Hundsberger H, Wiesner C, Eger A. Organotypic three-dimensional cancer cell cultures mirror drug responses . Oncotarget. 2017 Nov 17;8(64):107423-107440. doi: 10.18632/oncotarget.22475. eCollection 2017 Dec 08. PMID: 29296175; PMCID: PMC5746077.
Copy Download .nbib Format: NLM
Share it on

Oncotarget. 2017 Nov 17;8(64):107423-107440. doi: 10.18632/oncotarget.22475. eCollection 2017 Dec 08.

Organotypic three-dimensional cancer cell cultures mirror drug responses .

Oncotarget

Nico Jacobi, Rita Seeboeck, Elisabeth Hofmann, Helmut Schweiger, Veronika Smolinska, Thomas Mohr, Alexandra Boyer, Wolfgang Sommergruber, Peter Lechner, Corina Pichler-Huebschmann, Kamil Önder, Harald Hundsberger, Christoph Wiesner, Andreas Eger

Affiliations

  1. IMC University of Applied Sciences Krems, Department Life Sciences, Research Institute for Applied Bioanalytics and Drug Development, A-3500 Krems, Austria.
  2. IMC University of Applied Sciences Krems, Department Life Sciences, Institute of Medical and Pharmaceutical Biotechnology, A-3500 Krems, Austria.
  3. Medical University of Vienna, Institute for Cancer Research, A-1090 Vienna, Austria.
  4. Boehringer Ingelheim, RCV GmbH and Co KG, A-1121 Vienna, Austria.
  5. University Clinic Tulln, Department Surgery, A-3430 Tulln, Austria.
  6. Research Program for Rational Drug Design in Dermatology and Rheumatology, Department of Dermatology, Paracelsus Medical University of Salzburg, A-5020 Salzburg, Austria.
  7. ProComCure Biotech, A-5081 Anif, Austria.

PMID: 29296175 PMCID: PMC5746077 DOI: 10.18632/oncotarget.22475

Abstract

Complex three-dimensional (3D)

Keywords: 3D models; ERBB signaling; drug discovery; oncogene addiction; targeted drugs

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

References

  1. Gynecol Oncol. 2009 Apr;113(1):143-8 - PubMed
  2. Differentiation. 2002 Dec;70(9-10):537-46 - PubMed
  3. Nature. 2003 Aug 21;424(6951):870-2 - PubMed
  4. Oncogene. 2016 Mar 24;35(12 ):1554-64 - PubMed
  5. Int J Dev Biol. 2006;50(7):645-52 - PubMed
  6. Br J Cancer. 2014 Jan 7;110(1):55-62 - PubMed
  7. Chem Biol Interact. 2004 Nov 1;150(1):87-96 - PubMed
  8. Jpn J Clin Oncol. 1994 Aug;24(4):199-204 - PubMed
  9. Nat Genet. 2005 Dec;37(12):1315-6 - PubMed
  10. Magn Reson Med. 2017 Jul;78(1):156-164 - PubMed
  11. PLoS One. 2014 Mar 17;9(3):e92248 - PubMed
  12. Exp Cell Res. 2001 May 15;266(1):74-86 - PubMed
  13. Med Oncol. 2014 Oct;31(10):220 - PubMed
  14. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
  15. Front Genet. 2015 Feb 04;6:17 - PubMed
  16. Nat Rev Drug Discov. 2013 Mar;12(3):217-28 - PubMed
  17. PLoS One. 2014 Sep 23;9(9):e108283 - PubMed
  18. Mol Cancer Res. 2010 Jun;8(6):809-20 - PubMed
  19. Breast Cancer Res Treat. 2010 Jul;122(1):35-43 - PubMed
  20. J Biol Chem. 2007 Apr 27;282(17):12698-706 - PubMed
  21. J Biomol Screen. 2013 Dec;18(10 ):1330-7 - PubMed
  22. J Cell Physiol. 2015 Jan;230(1):16-26 - PubMed
  23. N Engl J Med. 2010 Jun 24;362(25):2380-8 - PubMed
  24. Sci Rep. 2015 Dec 09;5:17187 - PubMed
  25. Pharmacol Res. 2014 Jan;79:34-74 - PubMed
  26. Cancer Sci. 2014 Oct;105(10 ):1245-53 - PubMed
  27. Sci Rep. 2014 Oct 01;4:6468 - PubMed
  28. J Bioinform Comput Biol. 2011 Aug;9(4):559-77 - PubMed
  29. Expert Opin Drug Metab Toxicol. 2008 Nov;4(11):1379-89 - PubMed
  30. Cell. 2015 Jan 15;160(1-2):299-312 - PubMed
  31. Bioorg Med Chem. 2013 Feb 15;21(4):922-31 - PubMed
  32. Drug Discov Today. 2013 Mar;18(5-6):240-9 - PubMed
  33. JOP. 2014 Mar 10;15(2):114-7 - PubMed
  34. Nat Protoc. 2010 Sep;5(9):1540-51 - PubMed
  35. Clin Med Insights Oncol. 2014 Dec 07;8:139-44 - PubMed
  36. Neuro Oncol. 2012 Dec;14(12):1441-51 - PubMed
  37. Cell. 2002 Dec 27;111(7):923-5 - PubMed
  38. PLoS One. 2012;7(4):e34279 - PubMed
  39. J Cell Physiol. 2008 Jul;216(1):189-97 - PubMed
  40. Adv Biol Regul. 2017 Aug;65:36-58 - PubMed
  41. Cell. 2014 Sep 25;159(1):163-175 - PubMed
  42. Cancer Treat Rev. 2016 Mar;44:42-50 - PubMed
  43. Invest New Drugs. 2013 Dec;31(6):1458-65 - PubMed
  44. Drug Discov Today. 2002 Jun 1;7(11):612-20 - PubMed
  45. J Biotechnol. 2010 Jul 1;148(1):3-15 - PubMed
  46. Nature. 2012 Mar 28;483(7391):544-5 - PubMed
  47. J Surg Oncol. 1997 Aug;65(4):284-97 - PubMed
  48. Drug Discov Today. 2009 Jan;14(1-2):102-7 - PubMed
  49. Mol Oncol. 2014 Mar;8(2):351-65 - PubMed
  50. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3855-63 - PubMed
  51. BMC Cancer. 2009 Mar 26;9:94 - PubMed
  52. Exp Cell Res. 2009 Feb 15;315(4):557-71 - PubMed
  53. J Surg Oncol. 1996 Jan;61(1):68-83 - PubMed
  54. Adv Drug Deliv Rev. 2014 Dec 15;79-80:50-67 - PubMed
  55. PLoS Med. 2005 Sep;2(9):e269 - PubMed
  56. Annu Rev Cell Dev Biol. 2006;22:287-309 - PubMed
  57. Oncogene. 2015 Feb 12;34(7):815-25 - PubMed
  58. Adv Drug Deliv Rev. 2014 Apr;69-70:29-41 - PubMed
  59. Nat Rev Drug Discov. 2015 Jul;14(7):475-86 - PubMed
  60. Ann Oncol. 2006 Sep;17 Suppl 10:x263-8 - PubMed
  61. Methods Mol Biol. 2013;986:227-52 - PubMed
  62. Brief Funct Genomic Proteomic. 2009 Mar;8(2):158-66 - PubMed
  63. Genome Biol. 2004;5(10):R80 - PubMed
  64. Nat Rev Mol Cell Biol. 2006 Mar;7(3):211-24 - PubMed
  65. J Natl Cancer Inst. 2005 Aug 17;97(16):1185-94 - PubMed
  66. N Engl J Med. 2005 Feb 24;352(8):786-92 - PubMed
  67. Biotechnol Appl Biochem. 2016 Mar-Apr;63(2):190-9 - PubMed
  68. J Biol Chem. 2000 Apr 14;275(15):10761-6 - PubMed
  69. Oncogene. 2009 Jan 22;28(3):461-8 - PubMed
  70. Nat Rev Drug Discov. 2004 Aug;3(8):711-5 - PubMed
  71. PLoS One. 2014 Nov 07;9(11):e111029 - PubMed
  72. J Biomol Screen. 2013 Jan;18(1):54-66 - PubMed
  73. Sci Rep. 2016 Jun 23;6:28375 - PubMed
  74. Int J Oncol. 2013 Jun;42(6):2094-102 - PubMed
  75. Stat Appl Genet Mol Biol. 2004;3:Article3 - PubMed
  76. J Biomol Screen. 2007 Oct;12(7):925-37 - PubMed
  77. BMC Bioinformatics. 2008 Dec 29;9:559 - PubMed
  78. Arch Pharm Res. 2009 Jun;32(6):915-22 - PubMed
  79. Oncotarget. 2016 Feb 23;7(8):9017-25 - PubMed
  80. PLoS One. 2015 Apr 28;10(4):e0124283 - PubMed
  81. Clin Cancer Res. 2009 Nov 1;15(21):6630-8 - PubMed
  82. Cell. 2007 Aug 24;130(4):601-10 - PubMed
  83. Nat Rev Cancer. 2010 Apr;10(4):241-53 - PubMed
  84. Nat Rev Mol Cell Biol. 2014 Oct;15(10):647-64 - PubMed
  85. Semin Cancer Biol. 2005 Oct;15(5):405-12 - PubMed
  86. Methods. 2016 Mar 1;96:97-102 - PubMed
  87. N Engl J Med. 2004 May 20;350(21):2129-39 - PubMed
  88. Am J Pathol. 2011 Jul;179(1):487-501 - PubMed
  89. EMBO Rep. 2013 Aug;14(8):686-95 - PubMed
  90. Assay Drug Dev Technol. 2014 May;12(4):207-18 - PubMed
  91. Oncotarget. 2016 Sep 6;7(36):57752-57769 - PubMed
  92. Nat Rev Cancer. 2006 Oct;6(10 ):813-23 - PubMed
  93. Nature. 2012 Mar 28;483(7391):570-5 - PubMed
  94. Ann Oncol. 2016 Oct;27(10 ):1895-902 - PubMed
  95. Oncotarget. 2015 Sep 8;6(26):22348-60 - PubMed
  96. Crit Rev Oncol Hematol. 2000 Nov-Dec;36(2-3):123-39 - PubMed
  97. Nat Rev Mol Cell Biol. 2007 Oct;8(10):839-45 - PubMed
  98. Mol Carcinog. 2013 Mar;52(3):167-82 - PubMed
  99. Curr Opin Cell Biol. 2002 Oct;14(5):633-9 - PubMed
  100. Wiley Interdiscip Rev Syst Biol Med. 2013 Jan-Feb;5(1):1-9 - PubMed
  101. Bioinformatics. 2009 Feb 1;25(3):415-6 - PubMed
  102. N Engl J Med. 2005 Jul 14;353(2):207-8 - PubMed
  103. Cancer Res. 2006 Feb 1;66(3):1597-604 - PubMed
  104. Neuro Oncol. 2013 Jun;15(6):670-81 - PubMed
  105. Behav Brain Res. 2001 Nov 1;125(1-2):279-84 - PubMed
  106. Ann Surg. 1964 Feb;159:161-71 - PubMed
  107. Cell. 2014 Sep 25;159(1):176-187 - PubMed
  108. J Cell Physiol. 1989 Feb;138(2):384-92 - PubMed
  109. Crit Rev Oncol Hematol. 2000 Nov-Dec;36(2-3):193-207 - PubMed
  110. Genomics Proteomics Bioinformatics. 2014 Oct;12(5):198-209 - PubMed
  111. Mol Med Rep. 2014 Apr;9(4):1467-73 - PubMed
  112. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10101-6 - PubMed
  113. Nature. 2012 Mar 28;483(7391):603-7 - PubMed
  114. Curr Chem Genom Transl Med. 2014 Feb 07;8(Suppl 1):27-35 - PubMed
  115. Cancer Res. 2008 May 1;68(9):3077-80; discussion 3080 - PubMed
  116. Mol Carcinog. 2015 Apr;54(4):322-31 - PubMed
  117. Expert Opin Drug Discov. 2012 Sep;7(9):819-30 - PubMed
  118. PLoS One. 2013;8(3):e59689 - PubMed
  119. Adv Drug Deliv Rev. 2014 Apr;69-70:42-51 - PubMed
  120. J Cell Physiol. 2005 Aug;204(2):522-31 - PubMed
  121. Nat Protoc. 2009;4(3):309-24 - PubMed
  122. Bioinformatics. 2010 Oct 1;26(19):2363-7 - PubMed
  123. In Vitro Cell Dev Biol. 1986 Aug;22(8):449-56 - PubMed
  124. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7665-70 - PubMed
  125. In Vitro Cell Dev Biol Anim. 2006 Sep-Oct;42(8-9):242-7 - PubMed
  126. Semin Cancer Biol. 2005 Oct;15(5):342-52 - PubMed
  127. Tissue Eng. 2006 Aug;12(8):2151-60 - PubMed
  128. BMC Genomics. 2008 Feb 26;9:99 - PubMed
  129. Onco Targets Ther. 2015 Dec 07;8:3665-78 - PubMed
  130. Science. 2002 Jul 5;297(5578):63-4 - PubMed
  131. Clin Pharmacol Ther. 2012 Oct;92(4):467-75 - PubMed
  132. Nat Commun. 2016 Oct 26;7:13207 - PubMed
  133. J Thorac Oncol. 2013 Sep;8(9):1148-55 - PubMed
  134. Nucleic Acids Res. 2003 Feb 15;31(4):e15 - PubMed
  135. Cell. 2015 Jan 15;160(1-2):324-38 - PubMed
  136. Pharmacol Ther. 2016 Jul;163:94-108 - PubMed
  137. PLoS One. 2013 May 17;8(5):e63583 - PubMed
  138. Mol Oncol. 2007 Jun;1(1):84-96 - PubMed

Publication Types