Display options
Cite
Frentzel J, Sorrentino D, Giuriato S. Targeting Autophagy in ALK-Associated Cancers. Cancers (Basel). 2017;9(12)doi: 10.3390/cancers9120161.
Frentzel, J., Sorrentino, D., & Giuriato, S. (2017). Targeting Autophagy in ALK-Associated Cancers. Cancers, 9(12), . https://doi.org/10.3390/cancers9120161
Frentzel, Julie, et al. "Targeting Autophagy in ALK-Associated Cancers." Cancers vol. 9,12 (2017). doi: https://doi.org/10.3390/cancers9120161
Frentzel J, Sorrentino D, Giuriato S. Targeting Autophagy in ALK-Associated Cancers. Cancers (Basel). 2017 Nov 27;9(12). doi: 10.3390/cancers9120161. PMID: 29186933; PMCID: PMC5742809.
Copy Download .nbib Format: NLM
Share it on

Cancers (Basel). 2017 Nov 27;9(12). doi: 10.3390/cancers9120161.

Targeting Autophagy in ALK-Associated Cancers.

Cancers

Julie Frentzel, Domenico Sorrentino, Sylvie Giuriato

Affiliations

  1. Merck Serono S.A., Route de Fenil 25, Z.I. B, 1804 Corsier-sur-Vevey, Switzerland. [email protected].
  2. Inserm, UMR1037, CNRS, ERL5294, Université Toulouse III-Paul Sabatier, CRCT, F-31000 Toulouse, France. [email protected].
  3. Inserm, UMR1037, CNRS, ERL5294, Université Toulouse III-Paul Sabatier, CRCT, F-31000 Toulouse, France. [email protected].
  4. European Research Initiative on ALK-related malignancies (ERIA). [email protected].
  5. TRANSAUTOPHAGY: European Network for Multidisciplinary Research and Translation of Autophagy Knowledge, COST Action CA15138. [email protected].

PMID: 29186933 PMCID: PMC5742809 DOI: 10.3390/cancers9120161

Abstract

Autophagy is an evolutionarily conserved catabolic process, which is used by the cells for cytoplasmic quality control. This process is induced following different kinds of stresses e.g., metabolic, environmental, or therapeutic, and acts, in this framework, as a cell survival mechanism. However, under certain circumstances, autophagy has been associated with cell death. This duality has been extensively reported in solid and hematological cancers, and has been observed during both tumor development and cancer therapy. As autophagy plays a critical role at the crossroads between cell survival and cell death, its involvement and therapeutic modulation (either activation or inhibition) are currently intensively studied in cancer biology, to improve treatments and patient outcomes. Over the last few years, studies have demonstrated the occurrence of autophagy in different Anaplastic Lymphoma Kinase (ALK)-associated cancers, notably ALK-positive anaplastic large cell lymphoma (ALCL), non-small cell lung carcinoma (NSCLC), Neuroblastoma (NB), and Rhabdomyosarcoma (RMS). In this review, we will first briefly describe the autophagic process and how it can lead to opposite outcomes in anti-cancer therapies, and we will then focus on what is currently known regarding autophagy in ALK-associated cancers.

Keywords: ALK (anaplastic lymphoma kinase) oncogene; anaplastic large cell lymphoma (ALCL); autophagic switch; combined therapy; cytoprotective autophagy; cytotoxic autophagy; neuroblastoma (NB); non-small cell lung carcinoma (NSCLC); rhabdomyosarcoma (RMS); tyrosine kinase inhibitor (TKI)

Conflict of interest statement

The authors declare no conflict of interest.

References

  1. Nat Rev Cancer. 2008 Jan;8(1):11-23 - PubMed
  2. Cancer Genet. 2011 Mar;204(3):113-21 - PubMed
  3. Science. 1984 Jun 8;224(4653):1121-4 - PubMed
  4. Oncotarget. 2014 Sep 30;5(18):8737-49 - PubMed
  5. Autophagy. 2008 Jul;4(5):669-79 - PubMed
  6. Cancer Cell. 2013 Apr 15;23(4):435-49 - PubMed
  7. Am J Pathol. 2000 May;156(5):1711-21 - PubMed
  8. Mol Cancer Ther. 2012 Mar;11(3):670-9 - PubMed
  9. Cancer Biol Ther. 2012 Dec;13(14 ):1417-24 - PubMed
  10. Cell. 2016 Jul 14;166(2):288-298 - PubMed
  11. Leukemia. 2012 Jun;26(6):1195-202 - PubMed
  12. Methods Enzymol. 2017;587:87-96 - PubMed
  13. Nat Cell Biol. 2014 Jan;16(1):47-54 - PubMed
  14. Cell Death Differ. 2011 Jun;18(6):959-73 - PubMed
  15. Cell. 2007 Dec 14;131(6):1190-203 - PubMed
  16. Oncotarget. 2015 Oct 6;6(30):30149-64 - PubMed
  17. J Immunother Cancer. 2016 May 17;4:25 - PubMed
  18. Nature. 1977 Nov 10;270(5633):174-6 - PubMed
  19. Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:375-398 - PubMed
  20. Cell Death Differ. 2004 Apr;11(4):448-57 - PubMed
  21. Methods. 2015 Mar;75:25-36 - PubMed
  22. Science. 1994 Mar 4;263(5151):1281-4 - PubMed
  23. Oncogene. 2014 Apr 24;33(17):2236-44 - PubMed
  24. Expert Rev Mol Med. 2009 Dec 02;11:e36 - PubMed
  25. EMBO Rep. 2014 Aug;15(8):839-52 - PubMed
  26. Cancer Med. 2017 Nov;6(11):2625-2634 - PubMed
  27. Cell Death Differ. 2011 Oct;18(10 ):1584-97 - PubMed
  28. J Clin Oncol. 2012 Jan 20;30(3):308-15 - PubMed
  29. N Engl J Med. 2014 Dec 4;371(23):2167-77 - PubMed
  30. Horm Cancer. 2011 Oct;2(5):272-85 - PubMed
  31. Cancer Biol Ther. 2014 May;15(5):570-7 - PubMed
  32. Oncotarget. 2016 Jul 26;7(30):48501-48516 - PubMed
  33. Oncoimmunology. 2013 Jun 1;2(6):e24568 - PubMed
  34. Genes Chromosomes Cancer. 2008 Oct;47(10 ):819-34 - PubMed
  35. Cell Rep. 2014 Apr 10;7(1):45-52 - PubMed
  36. Expert Opin Investig Drugs. 2012 Jul;21(7):985-94 - PubMed
  37. Br J Cancer. 2013 Dec 10;109(12):3084-91 - PubMed
  38. Autophagy. 2010 Nov;6(8):1214-5 - PubMed
  39. Genes Dev. 2007 Nov 1;21(21):2683-710 - PubMed
  40. J Biol Chem. 2004 Apr 30;279(18):18384-91 - PubMed
  41. Cell Tissue Res. 2017 Sep 19;:null - PubMed
  42. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3314-22 - PubMed
  43. Oncoimmunology. 2014 Dec 21;3(11):e963424 - PubMed
  44. Oncogene. 2017 Oct 23;:null - PubMed
  45. Nat Commun. 2014;5:3056 - PubMed
  46. Oncotarget. 2016 Feb 2;7(5):5646-63 - PubMed
  47. N Engl J Med. 2010 Oct 28;363(18):1734-9 - PubMed
  48. J Clin Invest. 2010 Apr;120(4):1310-23 - PubMed
  49. Science. 2015 May 15;348(6236):803-8 - PubMed
  50. Blood. 1999 May 1;93(9):3088-95 - PubMed
  51. Nat Rev Clin Oncol. 2012 Apr 03;9(5):268-77 - PubMed
  52. Cell Death Differ. 2005 Oct;12 (10 ):1297-309 - PubMed
  53. Exp Cell Res. 2015 May 1;333(2):195-200 - PubMed
  54. Autophagy. 2011 Sep;7(9):1071-3 - PubMed
  55. Leukemia. 2015 Jun;29(6):1390-401 - PubMed
  56. Autophagy. 2007 Jan-Feb;3(1):45-7 - PubMed
  57. Oncoimmunology. 2012 Sep 1;1(6):976-978 - PubMed
  58. J Natl Cancer Inst. 2014 Feb;106(2):djt378 - PubMed
  59. Oncogene. 2016 Jan 7;35(1):1-11 - PubMed
  60. J Thorac Oncol. 2010 Dec;5(12 ):2044-6 - PubMed
  61. Autophagy. 2014;10(12):2346-61 - PubMed
  62. Cancer Res. 2014 Feb 1;74(3):647-51 - PubMed
  63. Blood. 2013 Oct 3;122(14):2467-76 - PubMed
  64. Pediatr Hematol Oncol. 2013 Sep;30(6):509-19 - PubMed
  65. Clin Cancer Res. 2012 Mar 1;18(5):1472-82 - PubMed
  66. Blood. 2017 Feb 16;129(7):823-831 - PubMed
  67. J Exp Clin Cancer Res. 2015 Oct 06;34:112 - PubMed
  68. Am J Pathol. 1999 Oct;155(4):1353-9 - PubMed
  69. N Engl J Med. 2011 Feb 24;364(8):775-6 - PubMed
  70. Cancer Res. 2016 Aug 1;76(15):4457-69 - PubMed
  71. World J Clin Oncol. 2015 Oct 10;6(5):104-8 - PubMed
  72. Cell. 2005 Sep 23;122(6):927-39 - PubMed
  73. Curr Opin Cell Biol. 2010 Apr;22(2):124-31 - PubMed
  74. Autophagy. 2016;12 (1):1-222 - PubMed
  75. Nat Commun. 2016 Jan 28;7:10274 - PubMed
  76. J Clin Pathol. 2017 Jul;70(7):593-599 - PubMed
  77. Cancers (Basel). 2017 Mar 24;9(4):null - PubMed
  78. Methods Enzymol. 2017;587:351-364 - PubMed
  79. Nat Genet. 2013 Mar;45(3):279-84 - PubMed
  80. Clin Cancer Res. 2011 Oct 1;17(19):6229-38 - PubMed
  81. Autophagy. 2014 Jul;10(7):1327-34 - PubMed
  82. J Biol Chem. 2006 Mar 31;281(13):8518-27 - PubMed
  83. Cell Cycle. 2013 Apr 1;12 (7):1022-9 - PubMed
  84. Hematol Oncol Clin North Am. 2010 Feb;24(1):65-86 - PubMed
  85. Curr Opin Immunol. 2006 Feb;18(1):98-104 - PubMed
  86. Clin Cancer Res. 2011 Nov 15;17(22):7047-57 - PubMed
  87. J Clin Invest. 2008 Dec;118(12):3917-29 - PubMed
  88. Oncogene. 2015 Oct 1;34(40):5105-13 - PubMed
  89. Eur J Histochem. 2015 May 05;59(2):2481 - PubMed
  90. Nature. 2008 Oct 16;455(7215):967-70 - PubMed
  91. J Biol Chem. 2012 Apr 6;287(15):12455-68 - PubMed
  92. Cancer Biol Ther. 2011 Jan 15;11(2):127-37 - PubMed
  93. Autophagy. 2017 Jun 9;:1-8 - PubMed
  94. Nat Rev Cancer. 2013 Oct;13(10):685-700 - PubMed
  95. PLoS One. 2012;7(9):e45058 - PubMed
  96. Autophagy. 2017 Apr 3;13(4):757-758 - PubMed
  97. Mol Cancer Ther. 2006 Nov;5(11):2786-97 - PubMed
  98. J Biol Chem. 2014 Apr 11;289(15):10607-19 - PubMed
  99. Sarcoma. 2015;2015:826124 - PubMed
  100. J Cell Biol. 1990 Sep;111(3):941-53 - PubMed
  101. Lancet Oncol. 2013 May;14(6):472-80 - PubMed
  102. Blood. 2016 Feb 18;127(7):882-92 - PubMed
  103. Pharmacol Res. 2013 Feb;68(1):68-94 - PubMed
  104. Blood. 2010 Sep 30;116(13):2324-31 - PubMed
  105. Blood Cells Mol Dis. 1997 Dec;23(3):380-94 - PubMed
  106. Oncogene. 1997 Jan 30;14(4):439-49 - PubMed
  107. Invest New Drugs. 1996;14(1):55-67 - PubMed
  108. Int J Nanomedicine. 2015 Mar 10;10:1921-30 - PubMed
  109. Nat Immunol. 2015 Oct;16(10):1014-24 - PubMed
  110. Front Immunol. 2015 Apr 29;6:200 - PubMed
  111. Autophagy. 2015 ;11(1):60-74 - PubMed
  112. Annu Rev Cell Dev Biol. 2011;27:107-32 - PubMed
  113. Science. 2011 Dec 16;334(6062):1573-7 - PubMed
  114. Br J Haematol. 2016 May;173(4):560-72 - PubMed
  115. EMBO J. 2015 Apr 1;34(7):856-80 - PubMed
  116. Curr Opin Pharmacol. 2015 Aug;23:39-44 - PubMed
  117. Transl Lung Cancer Res. 2015 Feb;4(1):5-7 - PubMed
  118. Cancer Res. 2010 Dec 15;70(24):10038-43 - PubMed
  119. Immunity. 2007 Jan;26(1):79-92 - PubMed
  120. Autophagy. 2012 Aug;8(8):1215-26 - PubMed
  121. Autophagy. 2007 Sep-Oct;3(5):452-60 - PubMed
  122. Clin Cancer Res. 2016 Feb 15;22(4):948-60 - PubMed
  123. Crit Rev Oncol Hematol. 2016 Apr;100:107-16 - PubMed
  124. PLoS One. 2017 Aug 24;12 (8):e0183516 - PubMed
  125. Autophagy. 2016 Jun 2;12 (6):1029-46 - PubMed
  126. EMBO J. 2007 May 16;26(10 ):2527-39 - PubMed
  127. J Cell Biol. 1992 Oct;119(2):301-11 - PubMed
  128. J Cell Biol. 1967 Nov;35(2):C11-6 - PubMed
  129. Nat Rev Cancer. 2013 Jun;13(6):397-411 - PubMed
  130. Mol Cell. 2016 Nov 17;64(4):835-849 - PubMed
  131. Cell Res. 2014 Jan;24(1):9-23 - PubMed
  132. N Engl J Med. 2010 Oct 28;363(18):1727-33 - PubMed
  133. Autophagy. 2010 May;6(4):495-505 - PubMed
  134. Haematologica. 2011 Mar;96(3):464-7 - PubMed
  135. Cell Struct Funct. 2002 Dec;27(6):421-9 - PubMed
  136. Cell Mol Life Sci. 2011 May;68(9):1533-41 - PubMed
  137. Nature. 2014 Oct 30;514(7524):628-32 - PubMed
  138. Exp Cell Res. 2015 Apr 10;333(1):21-38 - PubMed
  139. EMBO J. 2017 Jul 3;36(13):1811-1836 - PubMed
  140. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2948-53 - PubMed
  141. Curr Opin Genet Dev. 2014 Jun;26:16-23 - PubMed
  142. Nature. 2007 Aug 2;448(7153):561-6 - PubMed
  143. Arch Dis Child. 2003 Apr;88(4):354-7 - PubMed
  144. J Thorac Oncol. 2014 Mar;9(3):285-94 - PubMed
  145. Med Sci (Paris). 2017 Mar;33(3):328-334 - PubMed
  146. Blood. 2012 Oct 25;120(17 ):3555-62 - PubMed
  147. Nat Rev Immunol. 2005 Apr;5(4):296-306 - PubMed
  148. Nature. 2008 Oct 16;455(7215):930-5 - PubMed
  149. Blood. 2002 May 15;99(10):3530-9 - PubMed
  150. Sci Rep. 2016 Jan 20;6:19423 - PubMed
  151. Cell Death Dis. 2016 Oct 27;7(10 ):e2434 - PubMed
  152. PLoS One. 2013 May 03;8(5):e63232 - PubMed

Publication Types