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Franzini M, Nesti A, Panetta D, et al. Correlation between gamma glutamyltransferase fractions and bone quality. J Biol Regul Homeost Agents. 2017;31(4)
Franzini, M., Nesti, A., Panetta, D., Fierabracci, V., Marchetti, S., Parchi, P. D., Caponi, L., Paolicchi, A., Musetti, V., Salvadori, P., Edmin, M., Pucci, A., Bonicoli, E., Scaglione, M., & Piolanti, N. (2017). Correlation between gamma glutamyltransferase fractions and bone quality. Journal of biological regulators and homeostatic agents, 31(4), .
Franzini, M, et al. "Correlation between gamma glutamyltransferase fractions and bone quality." Journal of biological regulators and homeostatic agents vol. 31,4 (2017).
Franzini M, Nesti A, Panetta D, Fierabracci V, Marchetti S, Parchi PD, Caponi L, Paolicchi A, Musetti V, Salvadori P, Edmin M, Pucci A, Bonicoli E, Scaglione M, Piolanti N. Correlation between gamma glutamyltransferase fractions and bone quality. J Biol Regul Homeost Agents. 2017 Oct-Dec,;31(4). PMID: 29186945.
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J Biol Regul Homeost Agents. 2017 Oct-Dec,;31(4).

Correlation between gamma glutamyltransferase fractions and bone quality.

Journal of biological regulators and homeostatic agents

M Franzini, A Nesti, D Panetta, V Fierabracci, S Marchetti, P D Parchi, L Caponi, A Paolicchi, V Musetti, P Salvadori, M Edmin, A Pucci, E Bonicoli, M Scaglione, N Piolanti

Affiliations

  1. Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy
  2. Department of Orthopaedics and Traumatology I, University of Pisa
  3. Institute of Clinical Physiology of National Research Council (IFC-CNR) of Pisa
  4. Department of Laboratory Medicine, Fondazione Toscana Gabriele Monasterio, Pisa, Italy
  5. Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy
  6. Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy
  7. Histopathology Department, University Hospital, Pisa, Italy

PMID: 29186945

Abstract

Gamma-glutamyltransferase (GGT) has been recently identified as a bone-resorbing factor. The aim of this study was to investigate the association between plasma GGT fractions levels and bone quality. Plasma GGT fractions were analysed by gel-filtration chromatography. Bone quality was established quantitatively by two micro-CT derived microarchitectural parameters: the BV/TV (mineralised bone volume/total volume), and the SMI (structure model index) that describes the rod-like (low resistant) or plate-like (high-resistant) shape of bone trabeculae. We enrolled 93 patients hospitalised for elective total hip replacement (group Arthrosis, n=46) or for proximal femoral fracture (group Fracture, n=47). Patients within the first quartile of BV/TV (Q1, osteoporotic patients, n=6) showed higher levels of b-GGT fraction [median (min-max): 3.37 (1.42–6.81)] compared to patients with normal bone density (fourth quartile Q4, n=10; 1.40 (0.83–4.36); p=0.0393]. Also, according to SMI, b-GGT value was higher in the subgroup with bone fragility [Q1, n=8: 1.36 (0.43–4.36); Q4, n=8: 5.10 (1.4 –7.60); p=0.0117]. In conclusion, patients characterised by fragile bone structure showed specifically higher levels of plasma b-GGT activity thus suggesting fractional GGT analysis as a possible biomarker in the diagnosis of osteoporosis.

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