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Vaajanen A, Vapaatalo H. A Single Drop in the Eye - Effects on the Whole Body?. Open Ophthalmol J. 2017;11:305-314doi: 10.2174/1874364101711010305.
Vaajanen, A., & Vapaatalo, H. (2017). A Single Drop in the Eye - Effects on the Whole Body?. The open ophthalmology journal, 11305-314. https://doi.org/10.2174/1874364101711010305
Vaajanen, Anu, and Vapaatalo, Heikki. "A Single Drop in the Eye - Effects on the Whole Body?." The open ophthalmology journal vol. 11 (2017): 305-314. doi: https://doi.org/10.2174/1874364101711010305
Vaajanen A, Vapaatalo H. A Single Drop in the Eye - Effects on the Whole Body?. Open Ophthalmol J. 2017 Oct 31;11:305-314. doi: 10.2174/1874364101711010305. eCollection 2017. PMID: 29299077; PMCID: PMC5725525.
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Open Ophthalmol J. 2017 Oct 31;11:305-314. doi: 10.2174/1874364101711010305. eCollection 2017.

A Single Drop in the Eye - Effects on the Whole Body?.

The open ophthalmology journal

Anu Vaajanen, Heikki Vapaatalo

Affiliations

  1. Department of Ophthalmology, Tampere University Hospital, P.O. Box 2000, 33521 Tampere, Finland.
  2. SILK, Department of Ophthalmology, School of Medicine, University of Tampere, 33014, Tampere, Finland.
  3. Medical Faculty, Pharmacology, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland.

PMID: 29299077 PMCID: PMC5725525 DOI: 10.2174/1874364101711010305

Abstract

INTRODUCTION: Although the local adverse effects of ophthalmic drugs, including allergic reactions, are well recognized, less is known about the systemic side- effects of eye drops, especially during pregnancy, breast-feeding and early childhood. Ophthalmologists should also be aware of unusual, in some cases even life-threatening, effects of commonly used eye drops.

CONCLUSION: This brief review outlines the routes of systemic absorption and the kinetics of active components present in eye drops, and identifies the clinically relevant systemic adverse effects.

Keywords: Body ; Eye ; Kinetics ; Ocular drugs ; Ophthalmic drugs ; Single drop

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