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Oncotarget. 2017 Sep 28;8(56):95791-95798. doi: 10.18632/oncotarget.21327. eCollection 2017 Nov 10.

Aggressiveness pattern and second primary tumor risk associated with basaloid squamous cell carcinoma of the larynx.

Oncotarget

Filippo Ricciardiello, Michele Caraglia, Brigida Iorio, Teresa Abate, Mariarosaria Boccellino, Giuseppe Colella, Flavia Oliva, Pierpaolo Ferrise, Silvia Zappavigna, Mario Faenza, Giuseppe A Ferraro, Giulio Sequino, Giovanni Francesco Nicoletti, Massimo Mesolella

Affiliations

  1. Division of Otolaryngology, "A. Cardarelli" Hospital, Naples, Italy.
  2. Department of Biochemistry, Biophysics and General Pathology, University of Campania "L. Vanvitelli", Naples, Italy.
  3. Department of Neurological, Reproductive and Odontostomatological Sciences, University "Federico II" of Naples, Naples, Italy.
  4. Department of Medical, Surgical and Dental Specialties, University of Campania "L. Vanvitelli", Naples, Italy.

PMID: 29221167 PMCID: PMC5707061 DOI: 10.18632/oncotarget.21327

Abstract

Basaloid squamous cell carcinoma (BSCC) is a rare, aggressive and distinct variant of squamous cell carcinoma (SCC) of the upper respiratory and digestive tract. We have evaluated disease specific survival (DSS) and overall survival (OS) through Kaplan-Meier method and mortality risk through univariate statistical analysis of Cox in 42 cases of BSCC and other 42 of laryngeal SCC (LSCC) matched for both age and sex. We demonstrated that laryngeal BSCC is a more aggressive tumor than LSCC as is associated to higher nodal recurrence of pathology (

Keywords: laryngea lbasaloid squamocellular carcinoma (BSCC); loco-regional recurrence in laryngeal BSCC; mortality of laryngeal BSCC; prognosis of laryngeal basaloid squamous cell carcinoma

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare they have no known conflicts of interest in this work.

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