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Chen JP, Chen RF, Peng AJ, et al. Is compensatory hyperhidrosis after thoracic sympathicotomy in palmar hyperhidrosis patients related to the excitability of thoracic sympathetic ganglions?. J Thorac Dis. 2017;9(9):3069-3075doi: 10.21037/jtd.2017.08.100.
Chen, J. P., Chen, R. F., Peng, A. J., Xu, C. H., & Li, G. Y. (2017). Is compensatory hyperhidrosis after thoracic sympathicotomy in palmar hyperhidrosis patients related to the excitability of thoracic sympathetic ganglions?. Journal of thoracic disease, 9(9), 3069-3075. https://doi.org/10.21037/jtd.2017.08.100
Chen, Jun-Peng, et al. "Is compensatory hyperhidrosis after thoracic sympathicotomy in palmar hyperhidrosis patients related to the excitability of thoracic sympathetic ganglions?." Journal of thoracic disease vol. 9,9 (2017): 3069-3075. doi: https://doi.org/10.21037/jtd.2017.08.100
Chen JP, Chen RF, Peng AJ, Xu CH, Li GY. Is compensatory hyperhidrosis after thoracic sympathicotomy in palmar hyperhidrosis patients related to the excitability of thoracic sympathetic ganglions?. J Thorac Dis. 2017 Sep;9(9):3069-3075. doi: 10.21037/jtd.2017.08.100. PMID: 29221281; PMCID: PMC5708485.
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J Thorac Dis. 2017 Sep;9(9):3069-3075. doi: 10.21037/jtd.2017.08.100.

Is compensatory hyperhidrosis after thoracic sympathicotomy in palmar hyperhidrosis patients related to the excitability of thoracic sympathetic ganglions?.

Journal of thoracic disease

Jun-Peng Chen, Rui-Fu Chen, A-Jing Peng, Chen-Hui Xu, Guo-Ying Li

Affiliations

  1. Department of Thoracic Surgery, Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361000, China.

PMID: 29221281 PMCID: PMC5708485 DOI: 10.21037/jtd.2017.08.100

Abstract

BACKGROUND: The mechanism of compensatory hyperhidrosis remains unclear. The aim of this study was to explore the relationship between compensatory hyperhidrosis and thoracic sympathetic ganglion excitability to assess the effectiveness of thoracoscopic T4 sympathicotomy for treating palmar hyperhidrosis.

METHODS: Sixty-six cases of T4 sympathetic ganglions were prospectively collected from patients with palmar hyperhidrosis who underwent thoracoscopic T4 sympathicotomy from 2013 to 2016 in our department. The expression levels of choline acetyltransferase (ChAT), vasoactive intestinal peptide (VIP), and synaptophysin were detected using immunohistochemistry. Patients with palmar hyperhidrosis were followed-up for examination of postoperative sweating status.

RESULTS: Thirty-eight cases (57.6%) of compensatory hyperhidrosis were identified. Mild compensatory hyperhidrosis occurred in 26 patients (39.4%), moderate in 11 (16.7%), and severe in 1 (1.5%). The rate of compensatory hyperhidrosis was higher in patients with axilla hyperhidrosis than those without (76.0%

CONCLUSIONS: There was no significant correlation between compensatory hyperhidrosis and thoracic sympathetic ganglion excitability; however, compensatory hyperhidrosis is more likely to simultaneously occur in patients with axilla hyperhidrosis. The satisfactory efficacy of thoracoscopic T4 sympathicotomy indicates that it may an ideal technique for palmar hyperhidrosis.

Keywords: Hyperhidrosis; compensatory; excitability; sympathicotomy

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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