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Oncotarget. 2017 May 27;8(57):96732-96737. doi: 10.18632/oncotarget.18235. eCollection 2017 Nov 14.

Targeting CXCR4 with [.

Oncotarget

Constantin Lapa, Stefan Kircher, Andreas Schirbel, Andreas Rosenwald, Saskia Kropf, Theo Pelzer, Thorsten Walles, Andreas K Buck, Wolfgang A Weber, Hans-Juergen Wester, Ken Herrmann, Katharina Lückerath

Affiliations

  1. Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
  2. Institute of Pathology, University of Würzburg, Comprehensive Cancer Center Mainfranken (CCCMF), Würzburg, Germany.
  3. Scintomics GmbH, Fürstenfeldbruck, Germany.
  4. Department of Internal Medicine I, Division of Pulmonology, Universitätsklinikum Würzburg, Würzburg, Germany.
  5. Department of Thoracic Surgery, University Hospital Magdeburg, Magdeburg, Germany.
  6. Molecular Imaging and Therapy Service, Memorial Sloan-Kettering Cancer Center and Weill-Cornell Medical College, New York, New York, USA.
  7. Pharmaceutical Radiochemistry, Technische Universität München, Munich, Germany.
  8. Department of Nuclear Medicine, University Hospital Essen, Essen, Germany.

PMID: 29228566 PMCID: PMC5722518 DOI: 10.18632/oncotarget.18235

Abstract

C-X-C motif chemokine receptor 4 (CXCR4) is a key factor for tumor growth and metastasis in several types of human cancer. This study investigated the feasibility of CXCR4-directed imaging with positron emission tomography/computed tomography (PET/CT) using [

Keywords: CXCR4; PET; [68Ga] pentixafor; pleural mesothelioma; theranostics

Conflict of interest statement

CONFLICTS OF INTEREST HJW is founder and shareholder of Scintomics. SKr is CEO of Scintomics. All other authors declare no conflict of interest.

References

  1. J Biol Chem. 1998 Feb 13;273(7):4282-7 - PubMed
  2. Theranostics. 2017 Jan 1;7(1):205-212 - PubMed
  3. Eur J Cancer Prev. 2008 Nov;17(6):525-34 - PubMed
  4. Theranostics. 2015 Mar 01;5(6):618-30 - PubMed
  5. Oncotarget. 2016 Feb 23;7(8):9288-95 - PubMed
  6. PLoS One. 2008;3(12):e4069 - PubMed
  7. ChemMedChem. 2011 Oct 4;6(10 ):1789-91 - PubMed
  8. Occup Environ Med. 2015 Sep;72(9):648-55 - PubMed
  9. EMBO Mol Med. 2015 Mar 03;7(4):477-87 - PubMed
  10. Circ Cardiovasc Imaging. 2016 Sep;9(9):e005217 - PubMed
  11. JACC Cardiovasc Imaging. 2015 Dec;8(12 ):1466-1468 - PubMed
  12. J Nucl Med. 2016 Feb;57(2):248-51 - PubMed
  13. Nucl Med Biol. 2014 Jan;41(1):84-9 - PubMed
  14. Eur J Cancer. 2013 Jan;49(1):219-30 - PubMed
  15. J Nucl Med. 2016 May;57(5):741-6 - PubMed
  16. Theranostics. 2016 Jan 25;6(3):428-34 - PubMed
  17. J Nucl Med. 2015 Mar;56(3):410-6 - PubMed
  18. Am J Clin Pathol. 2007 May;127(5):752-9 - PubMed
  19. J Nucl Med. 2011 Nov;52(11):1803-10 - PubMed
  20. Chest. 1999 Dec;116(6 Suppl):444S-445S - PubMed
  21. Biochim Biophys Acta. 2000 Feb 21;1500(2):227-40 - PubMed
  22. J Pathol. 2011 Mar;223(4):519-30 - PubMed

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