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Müller GA, Stangner K, Schmitt T, et al. Timing of transcription during the cell cycle: Protein complexes binding to E2F, E2F/CLE, CDE/CHR, or CHR promoter elements define early and late cell cycle gene expression. Oncotarget. 2016;8(58):97736-97748doi: 10.18632/oncotarget.10888.
Müller, G. A., Stangner, K., Schmitt, T., Wintsche, A., & Engeland, K. (2017). Timing of transcription during the cell cycle: Protein complexes binding to E2F, E2F/CLE, CDE/CHR, or CHR promoter elements define early and late cell cycle gene expression. Oncotarget, 8(58), 97736-97748. https://doi.org/10.18632/oncotarget.10888
Müller, Gerd A, et al. "Timing of transcription during the cell cycle: Protein complexes binding to E2F, E2F/CLE, CDE/CHR, or CHR promoter elements define early and late cell cycle gene expression." Oncotarget vol. 8,58 (2017): 97736-97748. doi: https://doi.org/10.18632/oncotarget.10888
Müller GA, Stangner K, Schmitt T, Wintsche A, Engeland K. Timing of transcription during the cell cycle: Protein complexes binding to E2F, E2F/CLE, CDE/CHR, or CHR promoter elements define early and late cell cycle gene expression. Oncotarget. 2016 Jul 28;8(58):97736-97748. doi: 10.18632/oncotarget.10888. eCollection 2017 Nov 17. PMID: 29228647; PMCID: PMC5716687.
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Oncotarget. 2016 Jul 28;8(58):97736-97748. doi: 10.18632/oncotarget.10888. eCollection 2017 Nov 17.

Timing of transcription during the cell cycle: Protein complexes binding to E2F, E2F/CLE, CDE/CHR, or CHR promoter elements define early and late cell cycle gene expression.

Oncotarget

Gerd A Müller, Konstanze Stangner, Thomas Schmitt, Axel Wintsche, Kurt Engeland

Affiliations

  1. Molecular Oncology, Medical School, University of Leipzig, 04103 Leipzig, Germany.
  2. Computational EvoDevo Group, Department of Computer Science and Interdisciplinary Center for Bioinformatics, University of Leipzig, 04107 Leipzig, Germany.

PMID: 29228647 PMCID: PMC5716687 DOI: 10.18632/oncotarget.10888

Abstract

A central question in cell cycle control is how differential gene expression is regulated. Timing of expression is important for correct progression through the cell cycle. E2F, CDE, and CHR promoter sites have been linked to transcriptional repression in resting cells and activation during the cell cycle. Further, the DREAM complex binds CHR or CDE/CHR elements of G

Keywords: CHR transcriptional element; DREAM complex; E2F; p53 tumor suppressor; transcriptional repression

Conflict of interest statement

CONFLICTS OF INTEREST None declared.

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