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Monda V, La Marra M, Perrella R, et al. Obesity and brain illness: from cognitive and psychological evidences to obesity paradox. Diabetes Metab Syndr Obes. 2017;10:473-479doi: 10.2147/DMSO.S148392.
Monda, V., La Marra, M., Perrella, R., Caviglia, G., Iavarone, A., Chieffi, S., Messina, G., Carotenuto, M., Monda, M., & Messina, A. (2017). Obesity and brain illness: from cognitive and psychological evidences to obesity paradox. Diabetes, metabolic syndrome and obesity : targets and therapy, 10473-479. https://doi.org/10.2147/DMSO.S148392
Monda, Vincenzo, et al. "Obesity and brain illness: from cognitive and psychological evidences to obesity paradox." Diabetes, metabolic syndrome and obesity : targets and therapy vol. 10 (2017): 473-479. doi: https://doi.org/10.2147/DMSO.S148392
Monda V, La Marra M, Perrella R, Caviglia G, Iavarone A, Chieffi S, Messina G, Carotenuto M, Monda M, Messina A. Obesity and brain illness: from cognitive and psychological evidences to obesity paradox. Diabetes Metab Syndr Obes. 2017 Nov 21;10:473-479. doi: 10.2147/DMSO.S148392. eCollection 2017. PMID: 29200883; PMCID: PMC5701608.
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Diabetes Metab Syndr Obes. 2017 Nov 21;10:473-479. doi: 10.2147/DMSO.S148392. eCollection 2017.

Obesity and brain illness: from cognitive and psychological evidences to obesity paradox.

Diabetes, metabolic syndrome and obesity : targets and therapy

Vincenzo Monda, Marco La Marra, Raffaella Perrella, Giorgio Caviglia, Alessandro Iavarone, Sergio Chieffi, Giovanni Messina, Marco Carotenuto, Marcellino Monda, Antonietta Messina

Affiliations

  1. Department of Experimental Medicine, Section of Human Physiology, University of Campania Luigi Vanvitelli, Naples, Italy.
  2. Neurological and Stroke Unit, CTO Hospital, AORN "Ospedali dei Colli", Naples, Italy.
  3. Department of Psychology, University of Campania Luigi Vanvitelli, Naples, Italy.
  4. Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
  5. Clinic of Child and Adolescent Neuropsychiatry, Department of Mental Health, Physical and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.

PMID: 29200883 PMCID: PMC5701608 DOI: 10.2147/DMSO.S148392

Abstract

Recent findings showed that obesity represents an additional risk factor to developing brain illness such as cognitive impairments and psychopathological disorders. However, some benefits of overweight in the elderly have been identified and an "obesity paradox" has been shown. Currently, it is still unknown how obesity and brain functioning could be linked, and the process by which body fat independently injures cognitive abilities and psychological well-being remains unclear. To establish the independent role of obesity on cognitive abilities and mental health, clarifying the role played by several factors and understanding their interaction is essential. In this review, we discuss the relationship between obesity and brain illness and underline the role played by confounders and other covariates to determine this link.

Keywords: cognitive decline; mood disorders; obesity; obesity paradox

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

References

  1. Br J Nutr. 2004 Sep;92 (3):347-55 - PubMed
  2. Eur J Clin Nutr. 2002 Apr;56(4):305-12 - PubMed
  3. Pediatrics. 2002 Sep;110(3):497-504 - PubMed
  4. Nat Rev Immunol. 2011 Feb;11(2):85-97 - PubMed
  5. Neurology. 2009 Nov 10;73(19):1559-66 - PubMed
  6. Science. 1993 Jan 1;259(5091):87-91 - PubMed
  7. BMJ. 2005 Jun 11;330(7504):1360 - PubMed
  8. J Korean Med Sci. 2010 Nov;25(11):1560-7 - PubMed
  9. J Clin Psychiatry. 2004 May;65(5):634-51, quiz 730 - PubMed
  10. Hum Brain Mapp. 2010 Mar;31(3):353-64 - PubMed
  11. Obes Rev. 2011 May;12(5):e426-37 - PubMed
  12. J Affect Disord. 2009 Nov;118(1-3):155-60 - PubMed
  13. Arch Pediatr Adolesc Med. 2003 Aug;157(8):739-45 - PubMed
  14. Obes Surg. 2002 Aug;12(4):534-9 - PubMed
  15. Arch Neurol. 2009 Mar;66(3):336-42 - PubMed
  16. Int J Obes Relat Metab Disord. 2003 Feb;27(2):260-8 - PubMed
  17. Int J Obes Relat Metab Disord. 2003 Apr;27(4):514-21 - PubMed
  18. Am J Clin Nutr. 2005 Mar;81(3):543-54 - PubMed
  19. Obes Surg. 2001 Oct;11(5):581-8 - PubMed
  20. Arch Neurol. 2006 Sep;63(9):1312-7 - PubMed
  21. Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006189 - PubMed
  22. Neuroendocrinology. 2009;90(4):383-90 - PubMed
  23. Arch Intern Med. 2003 Jul 14;163(13):1524-8 - PubMed
  24. Front Neurosci. 2014 Nov 19;8:375 - PubMed
  25. Front Physiol. 2017 Feb 14;8:85 - PubMed
  26. Forensic Sci Int. 2008 Jul 18;179(1):e5-8 - PubMed
  27. Neurology. 2006 Oct 10;67(7):1208-14 - PubMed
  28. Arch Neurol. 2005 Oct;62(10):1556-60 - PubMed
  29. J Intern Med. 2007 Dec;262(6):643-50 - PubMed
  30. Am J Epidemiol. 2003 Dec 15;158(12):1139-47 - PubMed
  31. J Gerontol A Biol Sci Med Sci. 2009 Jan;64(1):103-9 - PubMed
  32. Arch Intern Med. 2005 Feb 14;165(3):321-6 - PubMed
  33. Arch Neurol. 2000 Jun;57(6):808-13 - PubMed
  34. Obes Rev. 2008 May;9(3):204-18 - PubMed
  35. Int J Obes Relat Metab Disord. 1992 Dec;16(12):999-1003 - PubMed
  36. Cochrane Database Syst Rev. 2002;(4):CD003804 - PubMed
  37. Neuroscience. 2010 Mar 17;166(2):416-21 - PubMed
  38. Somatosens Mot Res. 2016 Jun;33(2):137-44 - PubMed
  39. Neurology. 2004 Nov 23;63(10):1882-91 - PubMed
  40. Obesity (Silver Spring). 2013 May;21(5):993-6 - PubMed
  41. Neurology. 2003 Jan 14;60(1):117-9 - PubMed
  42. JAMA. 2004 Nov 10;292(18):2237-42 - PubMed
  43. Brain Res Rev. 2006 Aug;51(2):275-92 - PubMed
  44. Arch Neurol. 2005 Jan;62(1):55-60 - PubMed
  45. Am J Psychiatry. 1992 Feb;149(2):227-34 - PubMed
  46. Psychosom Med. 1998 May-Jun;60(3):338-46 - PubMed
  47. Neurobiol Aging. 2010 Aug;31(8):1326-39 - PubMed
  48. Age Ageing. 2007 Jan;36(1):23-9 - PubMed
  49. J Am Geriatr Soc. 2008 Dec;56(12):2261-6 - PubMed
  50. Pharmacol Res. 2011 Nov;64(5):517-27 - PubMed
  51. J Nutr Health Aging. 2010 Dec;14(10):834-8 - PubMed
  52. Neurology. 2005 Sep 27;65(6):892-7 - PubMed
  53. Neurology. 2009 May 19;72(20):1741-6 - PubMed
  54. Int J Obes (Lond). 2006 May;30(5):822-9 - PubMed
  55. Neurology. 2009 Dec 1;73(22):1899-905 - PubMed
  56. Science. 2013 Jan 11;339(6116):172-7 - PubMed
  57. Front Behav Neurosci. 2017 Jan 31;11:10 - PubMed
  58. Neuroimage. 2006 Jul 15;31(4):1419-25 - PubMed
  59. Psychiatr Clin North Am. 2011 Dec;34(4):717-32 - PubMed
  60. Neurochem Res. 2012 Dec;37(12 ):2795-804 - PubMed
  61. Obes Surg. 2001 Dec;11(6):680-5 - PubMed
  62. Obes Surg. 2003 Jun;13(3):371-7 - PubMed
  63. Neurology. 2011 Aug 2;77(5):461-8 - PubMed
  64. J Am Geriatr Soc. 2008 Jan;56(1):111-6 - PubMed
  65. Clin Neuropathol. 2009 Jan-Feb;28(1):40-5 - PubMed
  66. Curr Med Chem. 2013 Feb 1;20(6):833-9 - PubMed
  67. Arch Neurol. 2005 Oct;62(10):1545-8 - PubMed
  68. Lancet. 2014 Aug 30;384(9945):766-81 - PubMed
  69. JAMA. 1999 Dec 8;282(22):2131-5 - PubMed
  70. J Exp Clin Cancer Res. 2014 Jun 03;33:48 - PubMed
  71. Neurology. 2008 Jan 29;70(5):360-7 - PubMed
  72. J Neurosci Res. 2015 Mar;93(3):521-9 - PubMed
  73. Curr Alzheimer Res. 2007 Apr;4(2):123-6 - PubMed
  74. Brain. 2005 May;128(Pt 5):1093-101 - PubMed
  75. Epidemiol Rev. 2007;29:1-5 - PubMed
  76. Curr Alzheimer Res. 2007 Apr;4(2):103-9 - PubMed
  77. Monaldi Arch Chest Dis. 2007 Jun;68(2):87-95 - PubMed
  78. Dement Geriatr Cogn Disord. 2007;23(1):29-34 - PubMed
  79. BMC Neurol. 2005 Dec 02;5:23 - PubMed
  80. JAMA. 2001 Jul 18;286(3):327-34 - PubMed
  81. JAMA. 2009 Aug 12;302(6):627-37 - PubMed
  82. Neurology. 2000 Aug 22;55(4):484-89 - PubMed
  83. Arterioscler Thromb Vasc Biol. 1999 Apr;19(4):972-8 - PubMed
  84. J Alzheimers Dis. 2012;28(1):163-71 - PubMed
  85. Lancet Neurol. 2005 Aug;4(8):487-99 - PubMed
  86. Clin Exp Hypertens. 2008 Nov;30(8):798-807 - PubMed
  87. Neurobiol Dis. 2004 Jun;16(1):1-13 - PubMed
  88. J Alzheimers Dis. 2008 Sep;15(1):29-44 - PubMed
  89. Alzheimer Dis Assoc Disord. 2014 Jan-Mar;28(1):36-43 - PubMed
  90. Neurology. 2008 Sep 30;71(14):1057-64 - PubMed
  91. Neurology. 1998 Apr;50(4):966-71 - PubMed
  92. J Basic Clin Physiol Pharmacol. 2016 Nov 1;27(6):611-616 - PubMed
  93. Arch Neurol. 2007 Mar;64(3):392-8 - PubMed
  94. Neurology. 2004 Nov 23;63(10 ):1876-81 - PubMed
  95. Neurology. 2009 Jun 9;72(23):2029-35 - PubMed
  96. J Sports Sci. 2014;32(1):46-52 - PubMed
  97. Exp Brain Res. 2014 Nov;232(11):3659-64 - PubMed
  98. J Autism Dev Disord. 2007 Apr;37(4):775-9 - PubMed
  99. Int J Obes (Lond). 2009 Aug;33(8):893-8 - PubMed
  100. Am J Public Health. 2000 Feb;90(2):251-7 - PubMed
  101. Arch Intern Med. 2005 Jan 10;165(1):55-61 - PubMed
  102. Brain Behav Immun. 2014 Nov;42:10-21 - PubMed
  103. Mol Cell Endocrinol. 2002 Apr 25;190(1-2):91-9 - PubMed
  104. BMC Surg. 2013;13 Suppl 2:S50 - PubMed
  105. Obesity (Silver Spring). 2008 Jan;16(1):119-24 - PubMed

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