Display options
Cite
Parks XX, Contini D, Jordan PM, et al. Confirming a Role for α9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista. Front Cell Neurosci. 2017;11:356doi: 10.3389/fncel.2017.00356.
Parks, X. X., Contini, D., Jordan, P. M., & Holt, J. C. (2017). Confirming a Role for α9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista. Frontiers in cellular neuroscience, 11356. https://doi.org/10.3389/fncel.2017.00356
Parks, Xiaorong Xu, et al. "Confirming a Role for α9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista." Frontiers in cellular neuroscience vol. 11 (2017): 356. doi: https://doi.org/10.3389/fncel.2017.00356
Parks XX, Contini D, Jordan PM, Holt JC. Confirming a Role for α9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista. Front Cell Neurosci. 2017 Nov 21;11:356. doi: 10.3389/fncel.2017.00356. eCollection 2017. PMID: 29200999; PMCID: PMC5696599.
Copy Download .nbib Format: NLM
Share it on

Front Cell Neurosci. 2017 Nov 21;11:356. doi: 10.3389/fncel.2017.00356. eCollection 2017.

Confirming a Role for α9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista.

Frontiers in cellular neuroscience

Xiaorong Xu Parks, Donatella Contini, Paivi M Jordan, Joseph C Holt

Affiliations

  1. Department of Otolaryngology, University of Rochester, Rochester, NY, United States.
  2. Department of Neuroscience, University of Rochester, Rochester, NY, United States.
  3. Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, United States.

PMID: 29200999 PMCID: PMC5696599 DOI: 10.3389/fncel.2017.00356

Abstract

In turtle posterior cristae, cholinergic vestibular efferent neurons (VENs) synapse on type II hair cells, bouton afferents innervating type II hair cells, and afferent calyces innervating type I hair cells. Electrical stimulation of VENs releases acetylcholine (ACh) at these synapses to exert diverse effects on afferent background discharge including rapid inhibition of bouton afferents and excitation of calyx-bearing afferents. Efferent-mediated inhibition is most pronounced in bouton afferents innervating type II hair cells near the torus, but becomes progressively smaller and briefer when moving longitudinally through the crista toward afferents innervating the planum. Sharp-electrode recordings have inferred that efferent-mediated inhibition of bouton afferents requires the sequential activation of alpha9-containing nicotinic ACh receptors (α9

Keywords: SK; acetylcholine; alpha9; hair cell; nicotinic; vestibular

References

  1. J Neurophysiol. 1999 Nov;82(5):2451-61 - PubMed
  2. Exp Brain Res. 2011 May;210(3-4):607-21 - PubMed
  3. J Neurophysiol. 1996 Aug;76(2):995-1004 - PubMed
  4. Front Physiol. 2017 Aug 02;8:552 - PubMed
  5. Biophys J. 2000 Mar;78(3):1240-54 - PubMed
  6. J Neurosci. 2011 Nov 16;31(46):16814-25 - PubMed
  7. J Neurophysiol. 2007 Feb;97(2):1684-704 - PubMed
  8. J Biol Chem. 1997 Sep 12;272(37):23195-200 - PubMed
  9. J Neurophysiol. 1994 Jul;72(1):443-55 - PubMed
  10. Science. 2000 Jun 30;288(5475):2366-8 - PubMed
  11. Hear Res. 2000 Mar;141(1-2):51-6 - PubMed
  12. J Neurophysiol. 2000 Mar;83(3):1202-23 - PubMed
  13. Hear Res. 1996 Nov 1;101(1-2):132-48 - PubMed
  14. J Assoc Res Otolaryngol. 2014 Oct;15(5):755-66 - PubMed
  15. J Neurosci. 1998 Apr 15;18(8):2962-73 - PubMed
  16. J Neurophysiol. 2000 Mar;83(3):1224-42 - PubMed
  17. Hear Res. 2005 Nov;209(1-2):1-9 - PubMed
  18. J Vestib Res. 1999;9(5):359-67 - PubMed
  19. J Neurosci. 1997 Jan 1;17(1):428-37 - PubMed
  20. Proc Biol Sci. 1991 May 22;244(1310):161-7 - PubMed
  21. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18494-9 - PubMed
  22. Brain Res. 1984 Aug 6;308(1):191-5 - PubMed
  23. J Neurosci. 2017 Feb 15;37(7):1873-1887 - PubMed
  24. Brain Res. 1980 Mar 3;185(1):125-37 - PubMed
  25. J Assoc Res Otolaryngol. 2004 Jun;5(2):126-43 - PubMed
  26. J Neurophysiol. 2002 Dec;88(6):3259-78 - PubMed
  27. Neuroscience. 1993 Dec;57(4):1097-108 - PubMed
  28. J Med Chem. 1998 Jan 1;41(1):2-5 - PubMed
  29. J Neurophysiol. 2015 Dec;114(6):3154-65 - PubMed
  30. Physiol Behav. 2017 May 15;174:114-119 - PubMed
  31. J Neurosci. 2004 Dec 8;24(49):11160-4 - PubMed
  32. J Neurophysiol. 2003 Sep;90(3):1526-36 - PubMed
  33. J Neurosci. 2015 Feb 4;35(5):1821-30 - PubMed
  34. Neuropharmacology. 2000 Oct;39(13):2515-24 - PubMed
  35. J Comp Neurol. 1994 Jun 22;344(4):481-507 - PubMed
  36. J Comp Neurol. 2015 Jun 1;523(8):1258-80 - PubMed
  37. J Neurosci. 2003 Jul 30;23(17):6894-903 - PubMed
  38. J Neurophysiol. 2009 Sep;102(3):1513-25 - PubMed
  39. J Neurosci. 2015 Feb 25;35(8):3625-43 - PubMed
  40. Jpn J Physiol. 1991;41(2):217-32 - PubMed
  41. Brain Res. 2011 Feb 10;1373:25-38 - PubMed
  42. Cell. 1994 Nov 18;79(4):705-15 - PubMed
  43. Nat Rev Neurosci. 2004 Oct;5(10):758-70 - PubMed
  44. J Neurosci. 2006 Dec 20;26(51):13180-93 - PubMed
  45. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3501-6 - PubMed
  46. Prog Neurobiol. 1998 Feb;54(2):193-247 - PubMed
  47. Neuroscience. 1999;92(2):773-82 - PubMed
  48. J Comp Neurol. 2017 Apr 1;525(5):1216-1233 - PubMed
  49. J Neurophysiol. 1994 Jan;71(1):317-29 - PubMed
  50. J Neurophysiol. 2005 Nov;94(5):3134-42 - PubMed
  51. J Comp Neurol. 1997 Dec 22;389(3):419-43 - PubMed
  52. Science. 1996 Sep 20;273(5282):1709-14 - PubMed
  53. J Neurosci. 1992 Mar;12(3):800-9 - PubMed
  54. J Comp Physiol A. 1999 Nov;185(5):455-62 - PubMed
  55. Int J Mol Sci. 2013 Apr 24;14(5):8818-31 - PubMed
  56. PLoS One. 2010 Nov 04;5(11):e13836 - PubMed
  57. J Physiol. 2017 Feb 1;595(3):777-803 - PubMed
  58. Mol Pharmacol. 1999 Feb;55(2):248-54 - PubMed
  59. J Neurophysiol. 1997 Dec;78(6):3234-48 - PubMed
  60. Hear Res. 2002 May;167(1-2):122-35 - PubMed
  61. Hear Res. 2001 Feb;152(1-2):25-42 - PubMed
  62. J Neurophysiol. 2005 May;93(5):2541-51 - PubMed
  63. J Neurophysiol. 2007 Feb;97(2):1503-14 - PubMed
  64. J Vestib Res. 2013;23(3):161-75 - PubMed
  65. J Physiol. 2005 Jul 1;566(Pt 1):103-18 - PubMed
  66. J Neurophysiol. 1980 Apr;43(4):986-1025 - PubMed
  67. J Physiol. 1991 Oct;442:669-90 - PubMed
  68. J Neurophysiol. 2008 Oct;100(4):2287-99 - PubMed
  69. Neuron. 2000 Jun;26(3):595-601 - PubMed
  70. J Neurophysiol. 2003 Jul;90(1):155-64 - PubMed
  71. J Neurophysiol. 1985 Aug;54(2):370-84 - PubMed
  72. Hear Res. 1996 Nov 1;101(1-2):149-72 - PubMed
  73. PLoS One. 2012;7(9):e45732 - PubMed
  74. J Neurophysiol. 2015 Jan 1;113(1):264-76 - PubMed
  75. J Neurophysiol. 1995 Apr;73(4):1484-502 - PubMed

Publication Types

Grant support