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Ordookhani A, Burman KD. Hemostasis in Overt and Subclinical Hyperthyroidism. Int J Endocrinol Metab. 2017;15(3):e44157doi: 10.5812/ijem.44157.
Ordookhani, A., & Burman, K. D. (2017). Hemostasis in Overt and Subclinical Hyperthyroidism. International journal of endocrinology and metabolism, 15(3), e44157. https://doi.org/10.5812/ijem.44157
Ordookhani, Arash, and Burman, Kenneth D. "Hemostasis in Overt and Subclinical Hyperthyroidism." International journal of endocrinology and metabolism vol. 15,3 (2017): e44157. doi: https://doi.org/10.5812/ijem.44157
Ordookhani A, Burman KD. Hemostasis in Overt and Subclinical Hyperthyroidism. Int J Endocrinol Metab. 2017 Apr 23;15(3):e44157. doi: 10.5812/ijem.44157. eCollection 2017 Jul. PMID: 29201071; PMCID: PMC5702470.
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Int J Endocrinol Metab. 2017 Apr 23;15(3):e44157. doi: 10.5812/ijem.44157. eCollection 2017 Jul.

Hemostasis in Overt and Subclinical Hyperthyroidism.

International journal of endocrinology and metabolism

Arash Ordookhani, Kenneth D Burman

Affiliations

  1. Endocrine Section, Department of Internal Medicine, Providence Hospital, Washington, DC, 20017.
  2. Endocrine Section, MedStar Washington Hospital Center, Washington, DC, 20010.

PMID: 29201071 PMCID: PMC5702470 DOI: 10.5812/ijem.44157

Abstract

CONTEXT: There are contradictory results on the effect of hyperthyroidism on hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). The present review focuses on hemostatic changes in overt and subclinical hyperthyroidism.

METHODS: A systematic literature search was conducted employing MEDLINE database. The following words were used for the search: Hyperthyroidism; thyrotoxicosis; Graves disease; goiter, nodular; hemostasis; blood coagulation factors; blood coagulation disorders; venous thromboembolism; bleeding; fibrinolysis. The articles that were related to hyperthyroidism and hemostasis are used in this manuscript.

RESULTS: Hyperthyroidism, either overt or subclinical, renders a hypercoagulable state, although there are several studies with contradictory findings in the literature. Hypercoagulability may be caused by an increase in the level of various coagulation factors such as factor (F) VIII, FX, FIX, von Willebrand F (vWF), and fibrinogen, while hypofibrinolysis by changes in coagulation parameters such as a decrease in plasmin and plasmin activator or an increase in α2-antiplasmin, plasminogen activator inhibitor-1 and thrombin activatable fibrinolysis inhibitor.

CONCLUSIONS: Although many reports are in favor of a hypercoagulable state in overt hyperthyroidism but this finding at the biochemical level and its clinical implication, on the occurrence of VTE, has yet to be confirmed.

Keywords: Autoimmune; Blood Coagulation Factors; Fibrinolysis; Hashimoto Disease; Hyperthyroidism; Hypothyroidism; Myxedema; Thyroid Neoplasms; Thyroiditis; Venous Thromboembolism

Conflict of interest statement

Conflict Of Interest:None to declare

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