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Eser M, Basyigit S, Eser M, et al. Propylthiouracil-related Toxic Hepatitis: Impact of Silent Cases. Euroasian J Hepatogastroenterol. 2016;5(2):134-135doi: 10.5005/jp-journals-10018-1153.
Eser, M., Basyigit, S., Eser, M., & Nazligul, Y. (2015). Propylthiouracil-related Toxic Hepatitis: Impact of Silent Cases. Euroasian journal of hepato-gastroenterology, 5(2), 134-135. https://doi.org/10.5005/jp-journals-10018-1153
Eser, Murat, et al. "Propylthiouracil-related Toxic Hepatitis: Impact of Silent Cases." Euroasian journal of hepato-gastroenterology vol. 5,2 (2015): 134-135. doi: https://doi.org/10.5005/jp-journals-10018-1153
Eser M, Basyigit S, Eser M, Nazligul Y. Propylthiouracil-related Toxic Hepatitis: Impact of Silent Cases. Euroasian J Hepatogastroenterol. 2015 Jul-Dec;5(2):134-135. doi: 10.5005/jp-journals-10018-1153. Epub 2016 Jul 09. PMID: 29201711; PMCID: PMC5578545.
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Euroasian J Hepatogastroenterol. 2015 Jul-Dec;5(2):134-135. doi: 10.5005/jp-journals-10018-1153. Epub 2016 Jul 09.

Propylthiouracil-related Toxic Hepatitis: Impact of Silent Cases.

Euroasian journal of hepato-gastroenterology

Murat Eser, Sebahat Basyigit, Mithat Eser, Yasar Nazligul

Affiliations

  1. Department of Internal Medicine, Kecioren Research and Training Hospital, Ankara, Turkey.
  2. Department of Gastroenterology, Kecioren Research and Training Hospital, Ankara, Turkey.
  3. Department of Internal Medicine, Gulhane Millitary Medical Academy, Etlik, Turkey.

PMID: 29201711 PMCID: PMC5578545 DOI: 10.5005/jp-journals-10018-1153

Abstract

Liver is the main organ which can metabolize many drugs or chemical agents. Toxic events developed by drugs are one of the most common causes of liver damage. Toxic hepatitis can be encountered in different clinical situations, such as acute hepatitis, fulminant hepatitis chronic hepatitis or cirrhosis. We aimed to report a case of asymptomatic toxic hepatitis in a patient taking propylthiouracil (PTU). A 38 years old female patient admitted to hospital complained of fatigue. She had no special medical history except Graves' disease. She had been taking PTU 300 mg/day for 1 month. She had no history of another medication, eating mushroom, alcohol consumption, traveling, family history of liver disease. Her physical examination was normal. Laboratory analysis revealed that alanine aminotransferase-543 U/L, aspartate aminotransferase-227 U/L, gamma glutamyl transferase-66 U/L and alkaline phosphatase-136 U/L. Serum levels of bilirubin and albumin, INR, complete blood count and thyroid function tests were all normal. She had normal liver function test (LFT) before using PTU. Propylthiouracil was discontinued and she was given methimazole. She was examined for the etiology of abnormal LFT, but no specific etiology could be recorded. She was thought to have toxic hepatitis related to PTU. In her follow-up LFT has turned to normal level (Table 1).

HOW TO CITE THIS ARTICLE: Eser M, Basyigit S, Eser M, Nazligul Y. Propylthiouracil-related Toxic Hepatitis: Impact of Silent Cases. Euroasian J Hepato-Gastroenterol 2015;5(2):134-135.

Keywords: Liver function tests; Propylthioutacil; Toxic hepatitis.

Conflict of interest statement

Source of support: Nil Conflict of interest: None

References

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