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Hau H, Khanal D, Rogers L, et al. Dose enhancement and cytotoxicity of gold nanoparticles in colon cancer cells when irradiated with kilo- and mega-voltage radiation. Bioeng Transl Med. 2016;1(1):94-102doi: 10.1002/btm2.10007.
Hau, H., Khanal, D., Rogers, L., Suchowerska, N., Kumar, R., Sridhar, S., McKenzie, D., & Chrzanowski, W. (2016). Dose enhancement and cytotoxicity of gold nanoparticles in colon cancer cells when irradiated with kilo- and mega-voltage radiation. Bioengineering & translational medicine, 1(1), 94-102. https://doi.org/10.1002/btm2.10007
Hau, Herman, et al. "Dose enhancement and cytotoxicity of gold nanoparticles in colon cancer cells when irradiated with kilo- and mega-voltage radiation." Bioengineering & translational medicine vol. 1,1 (2016): 94-102. doi: https://doi.org/10.1002/btm2.10007
Hau H, Khanal D, Rogers L, Suchowerska N, Kumar R, Sridhar S, McKenzie D, Chrzanowski W. Dose enhancement and cytotoxicity of gold nanoparticles in colon cancer cells when irradiated with kilo- and mega-voltage radiation. Bioeng Transl Med. 2016 May 27;1(1):94-102. doi: 10.1002/btm2.10007. eCollection 2016 Mar. PMID: 29313009; PMCID: PMC5689506.
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Bioeng Transl Med. 2016 May 27;1(1):94-102. doi: 10.1002/btm2.10007. eCollection 2016 Mar.

Dose enhancement and cytotoxicity of gold nanoparticles in colon cancer cells when irradiated with kilo- and mega-voltage radiation.

Bioengineering & translational medicine

Herman Hau, Dipesh Khanal, Linda Rogers, Natalka Suchowerska, Rajiv Kumar, Srinivas Sridhar, David McKenzie, Wojciech Chrzanowski

Affiliations

  1. Faculty of Pharmacy The University of Sydney New South Wales 2006 Sydney, Australia.
  2. Chris O'Brien Lifehouse Sydney New South Wales 2006 Sydney, Australia.
  3. School of Physics The University of Sydney New South Wales 2006 Sydney, Australia.
  4. Nanomedicine Science and Technology Center and Dept. of Physics Northeastern University Boston MA 02115.
  5. Charles Perkins Centre, The University of Sydney New South Wales 2006 Sydney, Australia.
  6. Australian Institute of Nanoscale Science and Technology The University of Sydney, New South Wales 2006 Sydney, Australia.

PMID: 29313009 PMCID: PMC5689506 DOI: 10.1002/btm2.10007

Abstract

Despite major advances in the field of radiotherapy, healthy tissue damage continues to constrain the dose that can be prescribed in cancer therapy. Gold nanoparticles (GNPs) have been proposed as a solution to minimize radiation-associated toxicities by enhancing the radiation dose delivered locally to tumor cells. In the current study, we investigated the application of third-generation GNPs in two-dimensional (2D) and three-dimensional (3D) cell cultures and whether there is synergy between the nanoparticles and kilo- or mega-voltage radiation to cause augmented cytotoxicity. The 10-nm GNPs were found to be nontoxic in both 2D and 3D in vitro cultures of colon cancer cells at concentrations of up to 10-25 µg/ml. There was a significant increase in cell survival fraction reduction following exposure to 1 Gy of kilo-voltage (18.3%) and 2 Gy of mega-voltage (35.3%) radiation when the cells were incubated with 50 µg/ml of GNPs. The biocompatibility of the GNPs combined with their substantial synergy with radiation encourages further investigations into their application in targeted cancer treatment.

Keywords: colon cancer; gold nanoparticles; magnetic levitation; radiation dose enhancement; three‐dimensional cell culture

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