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Brenner JS, Kiseleva RY, Glassman PM, et al. The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series). Pulm Circ. 2017;8(1):2045893217752329doi: 10.1177/2045893217752329.
Brenner, J. S., Kiseleva, R. Y., Glassman, P. M., Parhiz, H., Greineder, C. F., Hood, E. D., Shuvaev, V. V., & Muzykantov, V. R. (2018). The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series). Pulmonary circulation, 8(1), 2045893217752329. https://doi.org/10.1177/2045893217752329
Brenner, Jacob S, et al. "The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)." Pulmonary circulation vol. 8,1 (2018): 2045893217752329. doi: https://doi.org/10.1177/2045893217752329
Brenner JS, Kiseleva RY, Glassman PM, Parhiz H, Greineder CF, Hood ED, Shuvaev VV, Muzykantov VR. The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series). Pulm Circ. 2018 Jan-Mar;8(1):2045893217752329. doi: 10.1177/2045893217752329. Epub 2017 Dec 20. PMID: 29261028; PMCID: PMC5768280.
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Pulm Circ. 2018 Jan-Mar;8(1):2045893217752329. doi: 10.1177/2045893217752329. Epub 2017 Dec 20.

The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series).

Pulmonary circulation

Jacob S Brenner, Raisa Yu Kiseleva, Patrick M Glassman, Hamideh Parhiz, Colin F Greineder, Elizabeth D Hood, Vladimir V Shuvaev, Vladimir R Muzykantov

Affiliations

  1. 1 14640 Pulmonary, Allergy, & Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA.
  2. 2 14640 Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

PMID: 29261028 PMCID: PMC5768280 DOI: 10.1177/2045893217752329

Abstract

The pulmonary vasculature plays an important role in many lung pathologies, such as pulmonary arterial hypertension, primary graft dysfunction of lung transplant, and acute respiratory distress syndrome. Therapy for these diseases is quite limited, largely due to dose-limiting side effects of numerous drugs that have been trialed or approved. High doses of drugs targeting the pulmonary vasculature are needed due to the lack of specific affinity of therapeutic compounds to the vasculature. To overcome this problem, the field of targeted drug delivery aims to target drugs to the pulmonary endothelial cells, especially those in pathological regions. The field uses a variety of drug delivery systems (DDSs), ranging from nano-scale drug carriers, such as liposomes, to methods of conjugating drugs to affinity moieites, such as antibodies. These DDSs can deliver small molecule drugs, protein therapeutics, and imaging agents. Here we review targeted drug delivery to the pulmonary endothelium for the treatment of pulmonary diseases. Cautionary notes are made of the risk-benefit ratio and safety-parameters one should keep in mind when developing a translational therapeutic.

Keywords: ARDS; acute respiratory distress syndromes and acute lung injury; drug delivery; endothelium; inflammation; vascular targeting

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