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Naderi NJ, Pasha MP. Comparison of Cytotoxic Effect of Cigarette and Waterpipe Smoking on Human Buccal Mucosa. Int J Prev Med. 2017;8:98doi: 10.4103/ijpvm.IJPVM_62_17.
Naderi, N. J., & Pasha, M. P. (2017). Comparison of Cytotoxic Effect of Cigarette and Waterpipe Smoking on Human Buccal Mucosa. International journal of preventive medicine, 898. https://doi.org/10.4103/ijpvm.IJPVM_62_17
Naderi, Noushin Jalayer, and Pasha, Mona Pour. "Comparison of Cytotoxic Effect of Cigarette and Waterpipe Smoking on Human Buccal Mucosa." International journal of preventive medicine vol. 8 (2017): 98. doi: https://doi.org/10.4103/ijpvm.IJPVM_62_17
Naderi NJ, Pasha MP. Comparison of Cytotoxic Effect of Cigarette and Waterpipe Smoking on Human Buccal Mucosa. Int J Prev Med. 2017 Dec 05;8:98. doi: 10.4103/ijpvm.IJPVM_62_17. eCollection 2017. PMID: 29291040; PMCID: PMC5738785.
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Int J Prev Med. 2017 Dec 05;8:98. doi: 10.4103/ijpvm.IJPVM_62_17. eCollection 2017.

Comparison of Cytotoxic Effect of Cigarette and Waterpipe Smoking on Human Buccal Mucosa.

International journal of preventive medicine

Noushin Jalayer Naderi, Mona Pour Pasha

Affiliations

  1. Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Shahed University, Tehran, Iran.
  2. Department of Oral Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 29291040 PMCID: PMC5738785 DOI: 10.4103/ijpvm.IJPVM_62_17

Abstract

BACKGROUND: The evidences on cytotoxic effect of cigarette and waterpipe smoking are very rare and controversial. The aim was to compare the cytotoxic effect of cigarette and waterpipe smoking on human buccal mucosa cells.

METHODS: The study was case-control. Feulgen-stained samples of exfoliated buccal mucosa cells were evaluated. The cytology slides of 25 cigarette smoker, 25 waterpipe smoker, and 25 individuals in the never smoked were examined. The number of pyknosis, karyorrhexis, and karyolysis in 1000 cells/subject were counted. Exposing to cigarette and waterpipe smoke was considered by the number of pack × years.

RESULTS: There were significant differences among the groups in terms of karyolysis and pyknosis while there was no significant difference among the cigarette smokers group and waterpipe smokers group in terms of karyorrhexis (

CONCLUSIONS: The cytotoxic effect of cigarette and waterpipe smoking on buccal mucosa cells was significantly higher than nonsmokers. The effect of cigarette smoking on cellular death was higher than waterpipe. The cytotoxic effect of waterpipe smoking was dose dependent.

Keywords: Buccal mucosa; cytotoxic agents; smoking

Conflict of interest statement

There are no conflicts of interest.

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