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Aisa R, Yu Z, Zhang X, et al. The Effects of Aqueous Extract from . Evid Based Complement Alternat Med. 2017;2017:4031950doi: 10.1155/2017/4031950.
Aisa, R., Yu, Z., Zhang, X., Maimaitiyiming, D., Huang, L., Hasim, A., Jiang, T., & Duan, M. (2017). The Effects of Aqueous Extract from . Evidence-based complementary and alternative medicine : eCAM, 20174031950. https://doi.org/10.1155/2017/4031950
Aisa, Rayile, et al. "The Effects of Aqueous Extract from ." Evidence-based complementary and alternative medicine : eCAM vol. 2017 (2017): 4031950. doi: https://doi.org/10.1155/2017/4031950
Aisa R, Yu Z, Zhang X, Maimaitiyiming D, Huang L, Hasim A, Jiang T, Duan M. The Effects of Aqueous Extract from . Evid Based Complement Alternat Med. 2017;2017:4031950. doi: 10.1155/2017/4031950. Epub 2017 Oct 11. PMID: 29234388; PMCID: PMC5660807.
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Evid Based Complement Alternat Med. 2017;2017:4031950. doi: 10.1155/2017/4031950. Epub 2017 Oct 11.

The Effects of Aqueous Extract from .

Evidence-based complementary and alternative medicine : eCAM

Rayile Aisa, Zhaoxia Yu, Xiangyang Zhang, Dilinuer Maimaitiyiming, Lipeng Huang, Ayshamgul Hasim, Tao Jiang, Mingjun Duan

Affiliations

  1. Cardiac Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
  2. Department of Internal Medicine, Kuqa County Hospital of Traditional Uyghur Medicine, Kuqa 842000, China.
  3. Department of Pathology, Xinjiang Medical University, Urumqi 830011, China.
  4. Institute of Clinical Medicine Research, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.

PMID: 29234388 PMCID: PMC5660807 DOI: 10.1155/2017/4031950

Abstract

AIMS: The aim of this study was to investigate the effects of the aqueous extract of

METHODS: 2K1C rat models were set up by clipping the left renal artery. Sham-operated rats underwent the same surgical procedure except for renal arterial clipping. 2K1C hypertensive rats were orally given NCBAE at doses of 210, 420, and 630 mg·kg

RESULTS: Treatment with NCBAE resulted in a decrease of SBP, LVPWd, LVPWs, IVSd, IVSs, LVW/BW ratio, and cardiomyocyte CSA, an increase of LVEF, and inhibition of 2K1C-induced reduction in serum NO and elevation of LDH compared with 2K1C group. NCBAE intervention also showed a significant increase of Bcl-2 expression and reduction of cleaved caspase-3 level dose-dependently in left ventricular tissue.

CONCLUSION: Our data demonstrate that NCBAE has an antihypertensive property and protective effect on 2K1C-induced cardiac hypertrophy especially at the dose of 630 mg·kg

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