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Chamaraux-Tran TN, Piegeler T. The Amide Local Anesthetic Lidocaine in Cancer Surgery-Potential Antimetastatic Effects and Preservation of Immune Cell Function? A Narrative Review. Front Med (Lausanne). 2017;4:235doi: 10.3389/fmed.2017.00235.
Chamaraux-Tran, T. N., & Piegeler, T. (2017). The Amide Local Anesthetic Lidocaine in Cancer Surgery-Potential Antimetastatic Effects and Preservation of Immune Cell Function? A Narrative Review. Frontiers in medicine, 4235. https://doi.org/10.3389/fmed.2017.00235
Chamaraux-Tran, Thiên-Nga, and Piegeler, Tobias. "The Amide Local Anesthetic Lidocaine in Cancer Surgery-Potential Antimetastatic Effects and Preservation of Immune Cell Function? A Narrative Review." Frontiers in medicine vol. 4 (2017): 235. doi: https://doi.org/10.3389/fmed.2017.00235
Chamaraux-Tran TN, Piegeler T. The Amide Local Anesthetic Lidocaine in Cancer Surgery-Potential Antimetastatic Effects and Preservation of Immune Cell Function? A Narrative Review. Front Med (Lausanne). 2017 Dec 20;4:235. doi: 10.3389/fmed.2017.00235. eCollection 2017. PMID: 29326939; PMCID: PMC5742360.
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Front Med (Lausanne). 2017 Dec 20;4:235. doi: 10.3389/fmed.2017.00235. eCollection 2017.

The Amide Local Anesthetic Lidocaine in Cancer Surgery-Potential Antimetastatic Effects and Preservation of Immune Cell Function? A Narrative Review.

Frontiers in medicine

Thiên-Nga Chamaraux-Tran, Tobias Piegeler

Affiliations

  1. Département d'Anesthésie et Réanimation Chirurgicale, Hôpital Hautepierre, CHU Strasbourg, Strasbourg, France.
  2. Institut de Génétique et de Biologie Moléculaire et Cellulaire, Unité Mixte de Recherche 7104, Centre National de la Recherche Scientifique, U964 Institut National de Santé et de Recherche Médicale, Université de Strasbourg, Illkirch, France.
  3. Department of Anesthesiology and Intensive Care Medicine, University Hospital Leipzig, Leipzig, Germany.

PMID: 29326939 PMCID: PMC5742360 DOI: 10.3389/fmed.2017.00235

Abstract

Surgical removal of the primary tumor in solid cancer is an essential component of the treatment. However, the perioperative period can paradoxically lead to an increased risk of cancer recurrence. A bimodal dynamics for early-stage breast cancer recurrence suggests a tumor dormancy-based model with a mastectomy-driven acceleration of the metastatic process and a crucial role of the immunosuppressive state during the perioperative period. Recent evidence suggests that anesthesia could also influence the progress of the disease. Local anesthetics (LAs) have long been used for their properties to block nociceptive input. They also exert anti-inflammatory capacities by modulating the liberation or signal propagation of inflammatory mediators. Interestingly, LAs can reduce viability and proliferation of many cancer cells

Keywords: breast cancer; immune system; inflammation; lidocaine; natural killer T-cells; perioperative period

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