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Schmidt JE, O'Brien TG, Hooten WM, et al. The effects of slow-paced versus mechanically assisted breathing on autonomic function in fibromyalgia patients. J Pain Res. 2017;10:2761-2768doi: 10.2147/JPR.S139642.
Schmidt, J. E., O'Brien, T. G., Hooten, W. M., Joyner, M. J., & Johnson, B. D. (2017). The effects of slow-paced versus mechanically assisted breathing on autonomic function in fibromyalgia patients. Journal of pain research, 102761-2768. https://doi.org/10.2147/JPR.S139642
Schmidt, John E, et al. "The effects of slow-paced versus mechanically assisted breathing on autonomic function in fibromyalgia patients." Journal of pain research vol. 10 (2017): 2761-2768. doi: https://doi.org/10.2147/JPR.S139642
Schmidt JE, O'Brien TG, Hooten WM, Joyner MJ, Johnson BD. The effects of slow-paced versus mechanically assisted breathing on autonomic function in fibromyalgia patients. J Pain Res. 2017 Dec 08;10:2761-2768. doi: 10.2147/JPR.S139642. eCollection 2017. PMID: 29263690; PMCID: PMC5727106.
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J Pain Res. 2017 Dec 08;10:2761-2768. doi: 10.2147/JPR.S139642. eCollection 2017.

The effects of slow-paced versus mechanically assisted breathing on autonomic function in fibromyalgia patients.

Journal of pain research

John E Schmidt, Travis G O'Brien, W Michael Hooten, Michael J Joyner, Bruce D Johnson

Affiliations

  1. Department of Psychology, Navy Medicine Professional Development Center, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences, Bethesda, MD.
  2. Department of Physical Medicine and Rehabilitation.
  3. Department of Anesthesiology, Division of Pain Medicine.
  4. Department of Medicine.
  5. Department of Physiology, Mayo Clinic, Rochester, MN, USA.

PMID: 29263690 PMCID: PMC5727106 DOI: 10.2147/JPR.S139642

Abstract

Paced breathing has shown efficacy in fibromyalgia (FM), but the mechanisms associated with symptom change are largely unknown. We investigated whether changes in respiratory rate (RR) alone resulted in autonomic changes during normal, paced, and mechanically assisted breathing in untrained FM patients and controls. Participants included 20 FM patients and 14 controls matched for age and body mass index. During a single visit, participants completed three 15-minute breathing sessions: 1) normal breathing, 2) slow-paced breathing, and 3) mechanically assisted breathing (continuous positive airway pressure) while supine. Continuous blood pressure and electrocardiogram were recorded, and measures of heart rate variability (HRV) and spontaneous baroreceptor sensitivity (sBRS) were calculated. During normal breathing, FM patients had higher heart rate (HR), but lower HRV and sBRS variables compared to controls with no difference in RR. Compared to the paced breathing condition, FM patients had significantly lower HR with higher HRV and sBRS variables during mechanically assisted breathing, despite no significant change in RR. Mechanically assisted breathing provided greater benefits in autonomic function than paced breathing in untrained FM patients. Future research will be needed to elucidate the central pathways involved in these autonomic changes and whether training in paced breathing can eventually replicate the results seen in mechanically assisted patients.

Keywords: autonomic activity; baroreceptor sensitivity; fibromyalgia; heart rate variability; mechanically assisted breathing; paced breathing

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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