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Polyzos SA, Makras P, Anastasilakis AD, et al. Periostin and sclerostin levels in juvenile Paget's disease. Clin Cases Miner Bone Metab. 2017;14(2):269-271doi: 10.11138/ccmbm/2017.14.2.269.
Polyzos, S. A., Makras, P., Anastasilakis, A. D., Mintziori, G., Kita, M., Papatheodorou, A., Kokkoris, P., & Terpos, E. (2017). Periostin and sclerostin levels in juvenile Paget's disease. Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, 14(2), 269-271. https://doi.org/10.11138/ccmbm/2017.14.2.269
Polyzos, Stergios A, et al. "Periostin and sclerostin levels in juvenile Paget's disease." Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases vol. 14,2 (2017): 269-271. doi: https://doi.org/10.11138/ccmbm/2017.14.2.269
Polyzos SA, Makras P, Anastasilakis AD, Mintziori G, Kita M, Papatheodorou A, Kokkoris P, Terpos E. Periostin and sclerostin levels in juvenile Paget's disease. Clin Cases Miner Bone Metab. 2017 May-Aug;14(2):269-271. doi: 10.11138/ccmbm/2017.14.2.269. Epub 2017 Oct 25. PMID: 29263750; PMCID: PMC5726226.
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Clin Cases Miner Bone Metab. 2017 May-Aug;14(2):269-271. doi: 10.11138/ccmbm/2017.14.2.269. Epub 2017 Oct 25.

Periostin and sclerostin levels in juvenile Paget's disease.

Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases

Stergios A Polyzos, Polyzois Makras, Athanasios D Anastasilakis, Gesthimani Mintziori, Marina Kita, Athanasios Papatheodorou, Panagiotis Kokkoris, Evangelos Terpos

Affiliations

  1. Department of Endocrinology, Ippokration General Hospital, Thessaloniki, Greece.
  2. Department of Endocrinology and Diabetes, 251 Hellenic Air Force & VA General Hospital, Athens, Greece.
  3. Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece.
  4. Department of Medical Research, 251 Hellenic Air Force & VA General Hospital, Athens, Greece.
  5. Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece.

PMID: 29263750 PMCID: PMC5726226 DOI: 10.11138/ccmbm/2017.14.2.269

Abstract

Juvenile Paget's disease (JPD) is a rare, autosomal recessive disorder featuring markedly increased serum alkaline phosphatase activity, indicative of greatly accelerated bone turnover throughout the skeleton. The main aim of this study was to evaluate circulating periostin and sclerostin levels in two adult patients with mild JPD (due to "Balkan" mutation). We measured periostin and sclerostin levels in a previously described woman and a newly diagnosed man with JPD, and 10 apparently healthy individuals, matched (1:5) to JPD patients for gender, age and body mass index. Sclerostin levels were similar between JPD patients and controls. Periostin levels were about 2.5 times higher in JPD patients. Periostin and sclerostin levels were negatively correlated (rs= -0.63; p=0.03). In conclusion, a trend towards higher periostin levels was observed in JPD patients, whereas sclerostin levels were similar to controls.

Keywords: CTX; PINP; juvenile Paget’s disease; periostin; sclerostin

Conflict of interest statement

Conflict of interest All Authors have no conflicts of interest.

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