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Olafsson S, Stridh P, Bos SD, et al. Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations. NPJ Genom Med. 2017;2:24doi: 10.1038/s41525-017-0027-2.
Olafsson, S., Stridh, P., Bos, S. D., Ingason, A., Euesden, J., Sulem, P., Thorleifsson, G., Gustafsson, O., Johannesson, A., Geirsson, A. J., Thorsson, A. V., Sigurgeirsson, B., Ludviksson, B. R., Olafsson, E., Kristjansdottir, H., Jonasson, J. G., Olafsson, J. H., Orvar, K. B., Benediktsson, R., Bjarnason, R., Kristjansdottir, S., Gislason, T., Valdimarsson, T., Mikaelsdottir, E., Sigurdsson, S., Jonsson, S., Rafnar, T., Aarsland, D., Djurovic, S., Fladby, T., Knudsen, G. P., Celius, E. G., Myhr, K. M., Grondal, G., Steinsson, K., Valdimarsson, H., Bjornsson, S., Bjornsdottir, U. S., Bjornsson, E. S., Nilsson, B., Andreassen, O. A., Alfredsson, L., Hillert, J., Kockum, I. S., Masson, G., Thorsteinsdottir, U., Gudbjartsson, D. F., Stefansson, H., Hjaltason, H., Harbo, H. F., Olsson, T., Jonsdottir, I., & Stefansson, K. (2017). Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations. NPJ genomic medicine, 224. https://doi.org/10.1038/s41525-017-0027-2
Olafsson, Sigurgeir, et al. "Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations." NPJ genomic medicine vol. 2 (2017): 24. doi: https://doi.org/10.1038/s41525-017-0027-2
Olafsson S, Stridh P, Bos SD, Ingason A, Euesden J, Sulem P, Thorleifsson G, Gustafsson O, Johannesson A, Geirsson AJ, Thorsson AV, Sigurgeirsson B, Ludviksson BR, Olafsson E, Kristjansdottir H, Jonasson JG, Olafsson JH, Orvar KB, Benediktsson R, Bjarnason R, Kristjansdottir S, Gislason T, Valdimarsson T, Mikaelsdottir E, Sigurdsson S, Jonsson S, Rafnar T, Aarsland D, Djurovic S, Fladby T, Knudsen GP, Celius EG, Myhr KM, Grondal G, Steinsson K, Valdimarsson H, Bjornsson S, Bjornsdottir US, Bjornsson ES, Nilsson B, Andreassen OA, Alfredsson L, Hillert J, Kockum IS, Masson G, Thorsteinsdottir U, Gudbjartsson DF, Stefansson H, Hjaltason H, Harbo HF, Olsson T, Jonsdottir I, Stefansson K. Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations. NPJ Genom Med. 2017 Aug 08;2:24. doi: 10.1038/s41525-017-0027-2. eCollection 2017. PMID: 29263835; PMCID: PMC5677966.
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NPJ Genom Med. 2017 Aug 08;2:24. doi: 10.1038/s41525-017-0027-2. eCollection 2017.

Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations.

NPJ genomic medicine

Sigurgeir Olafsson, Pernilla Stridh, Steffan Daniël Bos, Andres Ingason, Jack Euesden, Patrick Sulem, Gudmar Thorleifsson, Omar Gustafsson, Ari Johannesson, Arni J Geirsson, Arni V Thorsson, Bardur Sigurgeirsson, Bjorn Runar Ludviksson, Elias Olafsson, Helga Kristjansdottir, Jon G Jonasson, Jon Hjaltalin Olafsson, Kjartan B Orvar, Rafn Benediktsson, Ragnar Bjarnason, Sjofn Kristjansdottir, Thorarinn Gislason, Trausti Valdimarsson, Evgenia Mikaelsdottir, Snaevar Sigurdsson, Stefan Jonsson, Thorunn Rafnar, Dag Aarsland, Srdjan Djurovic, Tormod Fladby, Gun Peggy Knudsen, Elisabeth G Celius, Kjell-Morten Myhr, Gerdur Grondal, Kristjan Steinsson, Helgi Valdimarsson, Sigurdur Bjornsson, Unnur S Bjornsdottir, Einar S Bjornsson, Bjorn Nilsson, Ole A Andreassen, Lars Alfredsson, Jan Hillert, Ingrid Skelton Kockum, Gisli Masson, Unnur Thorsteinsdottir, Daniel F Gudbjartsson, Hreinn Stefansson, Haukur Hjaltason, Hanne F Harbo, Tomas Olsson, Ingileif Jonsdottir, Kari Stefansson

Affiliations

  1. deCODE genetics/Amgen, Reykjavik, Iceland.
  2. Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden.
  3. Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  4. Department of Neurology, Oslo University Hospital, Oslo, Norway.
  5. MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
  6. Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  7. Department of Medicine, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland.
  8. Center for Rheumatology Research, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland.
  9. Children's Medical Center, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland.
  10. Department of Dermatology, Faculty of Medicine, School of Health Sciences, University of Iceland, Kopavogur, Iceland.
  11. Department of Immunology, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland.
  12. Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
  13. Department of Neurology, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland.
  14. Department of Pathology, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland.
  15. The Medical Center, Glaesibae, Reykjavik, Iceland.
  16. Department of Endocrinology and Metabolic Medicine, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland.
  17. Department of Respiratory Medicine and Sleep, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland.
  18. Department of Medicine, West Iceland Healthcare Centre, Akranes, Iceland.
  19. Department of Old Age Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
  20. Division of Psychiatry, Stavanger University Hospital, Stavanger, Norway.
  21. Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
  22. Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
  23. Norwegian Institute of Public Health, Oslo, Norway.
  24. Department of Neurology, Oslo University Hospital Ullevål, Oslo, Norway.
  25. Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.
  26. Department of Clinical Medicine, University of Bergen, Bergen, Norway.
  27. Department of Neurology, Norwegian MS-Registry and Biobank, Haukeland University Hospital, Bergen, Norway.
  28. Department of Rheumatology, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland.
  29. Department of Laboratory Medicine, Hematology and Transfusion Medicine, BMC, Lund, Sweden.
  30. Division of Mental Health and Addiction, NORMENT, KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway.
  31. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  32. Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.
  33. School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.

PMID: 29263835 PMCID: PMC5677966 DOI: 10.1038/s41525-017-0027-2

Abstract

A meta-analysis of publicly available summary statistics on multiple sclerosis combined with three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven sequence variants associating with multiple sclerosis, not reported previously. Using polygenic risk scores based on public summary statistics of variants outside the major histocompatibility complex region we quantified genetic overlap between common autoimmune diseases in Icelanders and identified disease clusters characterized by autoantibody presence/absence. As multiple sclerosis-polygenic risk scores captures the risk of primary biliary cirrhosis and vice versa (

Conflict of interest statement

The authors who are affiliated with deCODE are all employees of deCODE genetics/Amgen Inc.

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