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Levi Sandri GB, Ettorre GM, Giannelli V, et al. Trans-arterial radio-embolization: a new chance for patients with hepatocellular cancer to access liver transplantation, a world review. Transl Gastroenterol Hepatol. 2017;2:98doi: 10.21037/tgh.2017.11.11.
Levi Sandri, G. B., Ettorre, G. M., Giannelli, V., Colasanti, M., Sciuto, R., Pizzi, G., Cianni, R., D'Offizi, G., Antonini, M., Vennarecci, G., & Lucatelli, P. (2017). Trans-arterial radio-embolization: a new chance for patients with hepatocellular cancer to access liver transplantation, a world review. Translational gastroenterology and hepatology, 298. https://doi.org/10.21037/tgh.2017.11.11
Levi Sandri, Giovanni Battista, et al. "Trans-arterial radio-embolization: a new chance for patients with hepatocellular cancer to access liver transplantation, a world review." Translational gastroenterology and hepatology vol. 2 (2017): 98. doi: https://doi.org/10.21037/tgh.2017.11.11
Levi Sandri GB, Ettorre GM, Giannelli V, Colasanti M, Sciuto R, Pizzi G, Cianni R, D'Offizi G, Antonini M, Vennarecci G, Lucatelli P. Trans-arterial radio-embolization: a new chance for patients with hepatocellular cancer to access liver transplantation, a world review. Transl Gastroenterol Hepatol. 2017 Nov 27;2:98. doi: 10.21037/tgh.2017.11.11. eCollection 2017. PMID: 29264436; PMCID: PMC5723750.
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Transl Gastroenterol Hepatol. 2017 Nov 27;2:98. doi: 10.21037/tgh.2017.11.11. eCollection 2017.

Trans-arterial radio-embolization: a new chance for patients with hepatocellular cancer to access liver transplantation, a world review.

Translational gastroenterology and hepatology

Giovanni Battista Levi Sandri, Giuseppe Maria Ettorre, Valerio Giannelli, Marco Colasanti, Rosa Sciuto, Giuseppe Pizzi, Roberto Cianni, Gianpiero D'Offizi, Mario Antonini, Giovanni Vennarecci, Pierleone Lucatelli

Affiliations

  1. Division of General Surgery and Liver Transplantation, S. Camillo Hospital, Rome, Italy.
  2. Division of Hepatology, S. Camillo Hospital, Rome, Italy.
  3. Division of Nuclear Medicine, IFO Regina Elena National Cancer Institute, Rome, Italy.
  4. Division of Interventional Radiology, IFO Regina Elena National Cancer Institute, Rome, Italy.
  5. Division of Interventional Radiology, S. Camillo Hospital, Rome, Italy.
  6. Division of Hepatology and Infectious Disease, National Institute for Infectious Disease "L. Spallanzani", Rome, Italy.
  7. Anesthesiology and Intensive Care Unit, National Institute for Infectious Disease "L. Spallanzani", Rome, Italy.
  8. Vascular and Interventional Radiology Unit, Department of Radiological, Oncological and Anatomo-pathological Sciences, Sapienza University of Rome, Rome, Italy.

PMID: 29264436 PMCID: PMC5723750 DOI: 10.21037/tgh.2017.11.11

Abstract

Liver transplantation (LT) for hepatocellular carcinoma (HCC) within the Milan criteria (MC) is nowadays a curative procedure. Yttrium-90 microspheres radioembolization (Y90-RE) has shown to be an effective and safe treatment of primary liver tumors. The aim of this work is to offer a view on the publications which report on the use of Y90-RE as bridge or downstaging prior to LT. Twenty articles have been considered for this world review. About 178 LT in patients were treated with Y90-RE prior to LT. Most of patients had a downstaging strategy. In all series alpha-fetoproteins decreased between Y90-RE and LT. Therefore, Y90-RE may have an important role in the bridge and downstaging treatments.

Keywords: Yttrium; bridging; downstaging; hepatocellular carcinoma (HCC); liver transplantation (LT); radioembolization

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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