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Gjesing AP, Rui G, Lauenborg J, et al. High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus. J Endocr Soc. 2017;1(6):681-690doi: 10.1210/js.2017-00040.
Gjesing, A. P., Rui, G., Lauenborg, J., Have, C. T., Hollensted, M., Andersson, E., Grarup, N., Sun, J., Quan, S., Brandslund, I., Damm, P., Pedersen, O., Wang, J., & Hansen, T. (2017). High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus. Journal of the Endocrine Society, 1(6), 681-690. https://doi.org/10.1210/js.2017-00040
Gjesing, Anette P, et al. "High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus." Journal of the Endocrine Society vol. 1,6 (2017): 681-690. doi: https://doi.org/10.1210/js.2017-00040
Gjesing AP, Rui G, Lauenborg J, Have CT, Hollensted M, Andersson E, Grarup N, Sun J, Quan S, Brandslund I, Damm P, Pedersen O, Wang J, Hansen T. High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus. J Endocr Soc. 2017 Apr 27;1(6):681-690. doi: 10.1210/js.2017-00040. eCollection 2017 Jun 01. PMID: 29264522; PMCID: PMC5686663.
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J Endocr Soc. 2017 Apr 27;1(6):681-690. doi: 10.1210/js.2017-00040. eCollection 2017 Jun 01.

High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus.

Journal of the Endocrine Society

Anette P Gjesing, Gao Rui, Jeannet Lauenborg, Christian Theil Have, Mette Hollensted, Ehm Andersson, Niels Grarup, Jihua Sun, Shi Quan, Ivan Brandslund, Peter Damm, Oluf Pedersen, Jun Wang, Torben Hansen

Affiliations

  1. The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
  2. BGI-Shenzhen, Shenzhen, 518083 China.
  3. Department of Gynecology and Obstetrics, Copenhagen University Hospital, 2730 Herlev, Denmark.
  4. Department of Clinical Biochemistry, Vejle Hospital, DK-7100 Vejle, Denmark.
  5. Institute of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark.
  6. Center for Pregnant Women With Diabetes, Department of Obstetrics, Rigshospitalet, 2100 Copenhagen, Denmark.
  7. Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

PMID: 29264522 PMCID: PMC5686663 DOI: 10.1210/js.2017-00040

Abstract

CONTEXT: Gestational diabetes mellitus (GDM), defined as any degree of glucose intolerance with first recognition during pregnancy, is a heterogeneous form of diabetes characterized by various degrees of

OBJECTIVES: We aimed to estimate the prevalence of possibly pathogenic variants in the maturity-onset diabetes of the young genes

DESIGN SETTING AND PATIENTS: We sequenced the coding regions and intron/exon boundaries of

MAIN OUTCOME MEASURES: The prevalence of possibly pathogenic variants in

RESULTS: At baseline, 17 possibly disease-causing variants were found in 21 women, revealing a combined

CONCLUSIONS: Almost 6% of Danish women with diet-treated GDM have possibly pathogenic variants in

Keywords: MODY; genes; genetic screening; gestational diabetes; monogenic diabetes

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