Display options
Cite
Sokolowska M, Frei R, Lunjani N, et al. Microbiome and asthma. Asthma Res Pract. 2018;4:1doi: 10.1186/s40733-017-0037-y.
Sokolowska, M., Frei, R., Lunjani, N., Akdis, C. A., & O'Mahony, L. (2018). Microbiome and asthma. Asthma research and practice, 41. https://doi.org/10.1186/s40733-017-0037-y
Sokolowska, Milena, et al. "Microbiome and asthma." Asthma research and practice vol. 4 (2018): 1. doi: https://doi.org/10.1186/s40733-017-0037-y
Sokolowska M, Frei R, Lunjani N, Akdis CA, O'Mahony L. Microbiome and asthma. Asthma Res Pract. 2018 Jan 05;4:1. doi: 10.1186/s40733-017-0037-y. eCollection 2018. PMID: 29318023; PMCID: PMC5755449.
Copy Download .nbib Format: NLM
Share it on

Asthma Res Pract. 2018 Jan 05;4:1. doi: 10.1186/s40733-017-0037-y. eCollection 2018.

Microbiome and asthma.

Asthma research and practice

Milena Sokolowska, Remo Frei, Nonhlanhla Lunjani, Cezmi A Akdis, Liam O'Mahony

Affiliations

  1. Swiss Institute of Allergy and Asthma Research, University of Zürich, Obere Strasse 22, 7270 Davos, Switzerland.
  2. Christine Kühne - Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
  3. University of Cape Town, Cape Town, South Africa.

PMID: 29318023 PMCID: PMC5755449 DOI: 10.1186/s40733-017-0037-y

Abstract

The mucosal immune system is in constant communication with the vast diversity of microbes present on body surfaces. The discovery of novel molecular mechanisms, which mediate host-microbe communication, have highlighted the important roles played by microbes in influencing mucosal immune responses. Dendritic cells, epithelial cells, ILCs, T regulatory cells, effector lymphocytes, NKT cells and B cells can all be influenced by the microbiome. Many of the mechanisms being described are bacterial strain- or metabolite-specific. Microbial dysbiosis in the gut and the lung is increasingly being associated with the incidence and severity of asthma. More accurate endotyping of patients with asthma may be assisted by further analysis of the composition and metabolic activity of an individual's microbiome. In addition, the efficacy of specific therapeutics may be influenced by the microbiome and novel bacterial-based therapeutics should be considered in future clinical studies.

Keywords: Asthma; Bacteria; Histamine; Immune tolerance; Microbiome; Mucosal immune system; Short-chain fatty acids

Conflict of interest statement

Not applicableNot applicableLOM is a consultant to Alimentary Health Ltd. and has received research funding from GlaxoSmithKline. CA has received research support from Novartis and Stallergenes and co

References

  1. PLoS One. 2012;7(10 ):e47556 - PubMed
  2. J Allergy Clin Immunol. 2013 Jul;132(1):194-204 - PubMed
  3. Microb Ecol Health Dis. 2017 Jan 01;28(1):1353881 - PubMed
  4. Nat Med. 2014 Feb;20(2):159-66 - PubMed
  5. J Allergy Clin Immunol. 2017 Mar;139(3):826-834.e13 - PubMed
  6. Am J Respir Crit Care Med. 2015 Mar 1;191(5):492-3 - PubMed
  7. J Allergy Clin Immunol. 2011 Nov;128(5):948-55.e1-3 - PubMed
  8. Clin Exp Allergy. 2002 Jul;32(7):1112-6 - PubMed
  9. Curr Opin Gastroenterol. 2015 Mar;31(2):153-8 - PubMed
  10. Allergy Asthma Clin Immunol. 2017 Jan 6;13:3 - PubMed
  11. J Allergy Clin Immunol. 2017 Jul;140(1):63-75 - PubMed
  12. Am J Respir Crit Care Med. 2014 Dec 1;190(11):1283-92 - PubMed
  13. J Allergy Clin Immunol. 2016 Jun;137(6):1909-1913.e4 - PubMed
  14. Am J Epidemiol. 2017 Mar 15;185(6):465-473 - PubMed
  15. Thorax. 2014 Jul;69(7):673-4 - PubMed
  16. Proc Am Thorac Soc. 2007 Jul;4(3):283-8 - PubMed
  17. Cell Host Microbe. 2014 Apr 9;15(4):413-23 - PubMed
  18. N Engl J Med. 2011 Feb 24;364(8):701-9 - PubMed
  19. J Allergy Clin Immunol. 2018 Jan;141(1):382-390.e7 - PubMed
  20. Eur J Clin Microbiol Infect Dis. 2018 Jan;37(1):1-7 - PubMed
  21. J Allergy Clin Immunol. 2017 Jul;140(1):1-12 - PubMed
  22. Cell Host Microbe. 2015 Aug 12;18(2):183-97 - PubMed
  23. Cell Host Microbe. 2015 May 13;17(5):704-15 - PubMed
  24. Am J Respir Crit Care Med. 2013 Jun 15;187(12):1382-7 - PubMed
  25. Allergy. 2012 Apr;67(4):451-61 - PubMed
  26. Appl Environ Microbiol. 2016 Nov 21;82(24):7185-7196 - PubMed
  27. Nature. 2012 Jun 13;486(7402):207-14 - PubMed
  28. PLoS Pathog. 2008 Aug 01;4(8):e1000112 - PubMed
  29. Lancet Respir Med. 2014 Aug;2(8):657-70 - PubMed
  30. J Allergy Clin Immunol. 2011 Feb;127(2):372-381.e1-3 - PubMed
  31. Am J Respir Crit Care Med. 2013 Nov 15;188(10):1193-201 - PubMed
  32. Gastroenterol Clin North Am. 2017 Mar;46(1):19-35 - PubMed
  33. N Engl J Med. 2007 Oct 11;357(15):1487-95 - PubMed
  34. Nat Med. 2014 Jun;20(6):642-7 - PubMed
  35. J Allergy Clin Immunol. 2016 Nov;138(5):1491-1494.e7 - PubMed
  36. Pediatr Int. 2017 Apr;59(4):473-481 - PubMed
  37. Sci Rep. 2017 May 12;7(1):1820 - PubMed
  38. Nat Commun. 2015 Jun 23;6:7320 - PubMed
  39. Am J Respir Crit Care Med. 2012 Sep 15;186(6):536-45 - PubMed
  40. N Engl J Med. 2016 Aug 4;375(5):411-421 - PubMed
  41. Allergy. 2017 Dec;72 (12 ):1925-1935 - PubMed
  42. EBioMedicine. 2016 Jul;9:336-345 - PubMed
  43. J Allergy Clin Immunol. 2015 Oct;136(4):874-84 - PubMed
  44. Science. 2015 Nov 27;350(6264):1084-9 - PubMed
  45. Eur J Immunol. 2018 Jan;48(1):39-49 - PubMed
  46. Clin Exp Allergy. 2010 May;40(5):811-9 - PubMed
  47. PLoS One. 2010 Jan 05;5(1):e8578 - PubMed
  48. J Allergy Clin Immunol. 2014 Apr;133(4):1056-64 - PubMed
  49. Allergy. 2011 Jan;66(1):39-47 - PubMed
  50. Am J Respir Crit Care Med. 2013 Nov 15;188(10):1246-52 - PubMed
  51. Sci Transl Med. 2016 Jun 15;8(343 ):343ra82 - PubMed
  52. Immunol Allergy Clin North Am. 2016 Aug;36(3):483-502 - PubMed
  53. J Immunol. 2005 Mar 15;174(6):3237-46 - PubMed
  54. N Engl J Med. 2002 Sep 19;347(12):869-77 - PubMed
  55. Clin Exp Allergy. 2014 Jun;44(6):842-50 - PubMed
  56. Gut Microbes. 2013 Jul-Aug;4(4):325-39 - PubMed
  57. PLoS Biol. 2013;11(8):e1001631 - PubMed
  58. J Immunol. 1997 Aug 15;159(4):1739-45 - PubMed
  59. Cell. 2015 Dec 3;163(6):1428-43 - PubMed
  60. Am J Respir Crit Care Med. 2016 Nov 1;194(9):1104-1115 - PubMed
  61. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13145-50 - PubMed
  62. PLoS One. 2012;7(10):e47711 - PubMed
  63. Curr Opin Immunol. 2017 Oct;48:108-113 - PubMed
  64. PLoS One. 2013 May 21;8(5):e62617 - PubMed
  65. PLoS One. 2014 Mar 06;9(3):e91097 - PubMed
  66. Microbiol Spectr. 2017 Aug;5(4):null - PubMed
  67. Nature. 2013 Aug 8;500(7461):232-6 - PubMed
  68. Springer Semin Immunopathol. 2004 Feb;25(3-4):237-55 - PubMed
  69. J Allergy Clin Immunol. 2013 Feb;131(2):346-52.e1-3 - PubMed
  70. Curr Allergy Asthma Rep. 2017 Aug 10;17 (9):62 - PubMed
  71. Gut. 2012 Mar;61(3):354-66 - PubMed
  72. Thorax. 2011 Sep;66(9):755-63 - PubMed
  73. Am J Physiol Cell Physiol. 2014 Dec 1;307(11):C979-85 - PubMed
  74. Br J Nutr. 2013 Jul 14;110(1):145-55 - PubMed
  75. PLoS One. 2016 Sep 22;11(9):e0162983 - PubMed
  76. Am J Respir Crit Care Med. 2011 Jul 15;184(2):198-205 - PubMed
  77. Sci Transl Med. 2015 Jan 21;7(271):271ps1 - PubMed
  78. MBio. 2015 Mar 03;6(2):e00037 - PubMed
  79. Sci Transl Med. 2015 Sep 30;7(307):307ra152 - PubMed
  80. Cell Host Microbe. 2015 May 13;17(5):592-602 - PubMed
  81. Nat Rev Microbiol. 2017 May;15(5):259-270 - PubMed
  82. J Allergy Clin Immunol. 2016 May;137(5):1398-1405.e3 - PubMed
  83. Front Immunol. 2017 Mar 31;8:365 - PubMed
  84. Am J Respir Crit Care Med. 2009 Feb 1;179(3):186-93 - PubMed
  85. J Immunol. 2003 Jul 15;171(2):1001-8 - PubMed
  86. J Allergy Clin Immunol. 2017 Apr;139(4):1379-1383 - PubMed
  87. Allergy. 2017 Jan;72 (1):109-119 - PubMed
  88. Science. 2015 Sep 4;349(6252):1106-10 - PubMed
  89. Allergy. 2016 May;71(5):588-92 - PubMed
  90. Ann Allergy Asthma Immunol. 2014 May;112(5):441-445.e1 - PubMed
  91. J Allergy Clin Immunol. 2017 Apr;139(4):1099-1110 - PubMed
  92. J Allergy Clin Immunol. 2015 Jan;135(1):25-30 - PubMed
  93. Nat Med. 2016 Oct;22(10 ):1187-1191 - PubMed
  94. Allergy. 2017 Dec;72 (12 ):1859-1867 - PubMed
  95. Clin Transl Immunology. 2017 Mar 10;6(3):e133 - PubMed
  96. Curr Opin Pulm Med. 2017 Jan;23 (1):41-47 - PubMed

Publication Types