Display options
Cite
Ikwegbue PC, Masamba P, Oyinloye BE, et al. Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer. Pharmaceuticals (Basel). 2017;11(1)doi: 10.3390/ph11010002.
Ikwegbue, P. C., Masamba, P., Oyinloye, B. E., & Kappo, A. P. (2017). Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer. Pharmaceuticals (Basel, Switzerland), 11(1), . https://doi.org/10.3390/ph11010002
Ikwegbue, Paul Chukwudi, et al. "Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer." Pharmaceuticals (Basel, Switzerland) vol. 11,1 (2017). doi: https://doi.org/10.3390/ph11010002
Ikwegbue PC, Masamba P, Oyinloye BE, Kappo AP. Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer. Pharmaceuticals (Basel). 2017 Dec 23;11(1). doi: 10.3390/ph11010002. PMID: 29295496; PMCID: PMC5874698.
Copy Download .nbib Format: NLM
Share it on

Pharmaceuticals (Basel). 2017 Dec 23;11(1). doi: 10.3390/ph11010002.

Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer.

Pharmaceuticals (Basel, Switzerland)

Paul Chukwudi Ikwegbue, Priscilla Masamba, Babatunji Emmanuel Oyinloye, Abidemi Paul Kappo

Affiliations

  1. Biotechnology and Structural Biochemistry (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa. [email protected].
  2. Biotechnology and Structural Biochemistry (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa. [email protected].
  3. Biotechnology and Structural Biochemistry (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa. [email protected].
  4. Department of Biochemistry, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria. [email protected].
  5. Biotechnology and Structural Biochemistry (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa. [email protected].

PMID: 29295496 PMCID: PMC5874698 DOI: 10.3390/ph11010002

Abstract

Heat shock proteins (HSPs) play cytoprotective activities under pathological conditions through the initiation of protein folding, repair, refolding of misfolded peptides, and possible degradation of irreparable proteins. Excessive apoptosis, resulting from increased reactive oxygen species (ROS) cellular levels and subsequent amplified inflammatory reactions, is well known in the pathogenesis and progression of several human inflammatory diseases (HIDs) and cancer. Under normal physiological conditions, ROS levels and inflammatory reactions are kept in check for the cellular benefits of fighting off infectious agents through antioxidant mechanisms; however, this balance can be disrupted under pathological conditions, thus leading to oxidative stress and massive cellular destruction. Therefore, it becomes apparent that the interplay between oxidant-apoptosis-inflammation is critical in the dysfunction of the antioxidant system and, most importantly, in the progression of HIDs. Hence, there is a need to maintain careful balance between the oxidant-antioxidant inflammatory status in the human body. HSPs are known to modulate the effects of inflammation cascades leading to the endogenous generation of ROS and intrinsic apoptosis through inhibition of pro-inflammatory factors, thereby playing crucial roles in the pathogenesis of HIDs and cancer. We propose that careful induction of HSPs in HIDs and cancer, especially prior to inflammation, will provide good therapeutics in the management and treatment of HIDs and cancer.

Keywords: apoptosis; cancer; heat shock proteins; inflammation; reactive oxygen species; tumour necrosis factor-α

Conflict of interest statement

The authors declare no conflict of interest.

References

  1. J Natl Cancer Inst. 2000 Oct 4;92(19):1564-72 - PubMed
  2. J Exp Med. 1995 Mar 1;181(3):943-52 - PubMed
  3. J Exp Biol. 2013 Dec 15;216(Pt 24):4514-9 - PubMed
  4. Intensive Care Med. 2011 Dec;37(12):1932-41 - PubMed
  5. Cold Spring Harb Perspect Biol. 2013 Apr 01;5(4):a008656 - PubMed
  6. J Clin Invest. 1997 Jul 15;100(2):459-63 - PubMed
  7. Experientia. 1994 Nov 30;50(11-12):1031-8 - PubMed
  8. Nat Rev Immunol. 2005 Apr;5(4):318-30 - PubMed
  9. Cell Stress Chaperones. 2011 May;16(3):235-49 - PubMed
  10. Oncogene. 2003 Dec 8;22(56):9041-7 - PubMed
  11. PLoS One. 2013;8(3):e58256 - PubMed
  12. J Asthma. 2012 Aug;49(6):575-80 - PubMed
  13. Science. 1993 Oct 29;262(5134):689-95 - PubMed
  14. Genome Biol. 2002 Jun 18;3(7):REVIEWS1019 - PubMed
  15. Autoimmune Dis. 2012;2012:486069 - PubMed
  16. Oxid Med Cell Longev. 2015;2015:610813 - PubMed
  17. Curr Opin Allergy Clin Immunol. 2001 Feb;1(1):85-93 - PubMed
  18. Blood. 2003 Nov 1;102(9):3379-86 - PubMed
  19. World J Gastroenterol. 2014 Oct 28;20(40):14660-71 - PubMed
  20. Curr Neuropharmacol. 2009 Mar;7(1):65-74 - PubMed
  21. J Surg Res. 2015 Jan;193(1):135-44 - PubMed
  22. Clin Exp Allergy. 1998 May;28(5):551-60 - PubMed
  23. N Engl J Med. 2005 Oct 20;353(16):1685-93 - PubMed
  24. Cancer Lett. 2013 May 28;332(2):275-85 - PubMed
  25. Cancer Res. 2005 Jun 1;65(11):4947-54 - PubMed
  26. Mol Biol Cell. 2008 Mar;19(3):1104-12 - PubMed
  27. Immunol Invest. 2007;36(3):233-46 - PubMed
  28. J Hepatol. 1995 Oct;23(4):382-90 - PubMed
  29. Trends Plant Sci. 2011 Jun;16(6):300-9 - PubMed
  30. Croat Med J. 2013 Dec;54(6):519-31 - PubMed
  31. J Cell Biol. 2011 Jul 11;194(1):7-15 - PubMed
  32. Free Radic Biol Med. 1995 Jun;18(6):1079-86 - PubMed
  33. J Clin Invest. 2002 Sep;110(6):737-9 - PubMed
  34. Exp Oncol. 2012 Oct;34(3):243-54 - PubMed
  35. Trends Cell Biol. 2001 Jan;11(1):6-10 - PubMed
  36. J Appl Physiol (1985). 2016 Mar 15;120(6):683-91 - PubMed
  37. Allergy. 1999 Feb;54(2):165-70 - PubMed
  38. J Biomed Biotechnol. 2012;2012:936486 - PubMed
  39. Shock. 1999 Jan;11(1):1-12 - PubMed
  40. Cell. 2000 Jan 7;100(1):57-70 - PubMed
  41. J Proteome Res. 2007 Jul;6(7):2648-55 - PubMed
  42. Reprod Domest Anim. 2012 Dec;47(6):975-83 - PubMed
  43. Ann Rheum Dis. 2006 Nov;65 Suppl 3:iii65-8 - PubMed
  44. Cell. 2006 May 5;125(3):443-51 - PubMed
  45. Respir Res. 2005 Feb 14;6:18 - PubMed
  46. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7871-6 - PubMed
  47. Cell Stress Chaperones. 2011 Nov;16(6):663-71 - PubMed
  48. Carcinogenesis. 2000 Mar;21(3):485-95 - PubMed
  49. Arthritis Rheum. 2010 Sep;62(9):2569-81 - PubMed
  50. Chem Biol Interact. 2014 Dec 5;224:164-75 - PubMed
  51. Oxid Med Cell Longev. 2016;2016:3164734 - PubMed
  52. Biomed Res Int. 2013;2013:484613 - PubMed
  53. Trends Pharmacol Sci. 2017 Mar;38(3):226-256 - PubMed
  54. Biomed Res Int. 2013;2013:461230 - PubMed
  55. Crit Care Med. 2008 Jan;36(1):246-55 - PubMed
  56. Immunopharmacol Immunotoxicol. 2009;31(3):388-96 - PubMed
  57. Lancet. 2016 Oct 8;388(10053):1545-1602 - PubMed
  58. N Engl J Med. 2000 May 4;342(18):1334-49 - PubMed
  59. Circulation. 1999 Sep 14;100(11):1169-74 - PubMed
  60. Circulation. 2002 Nov 19;106(21):2727-33 - PubMed
  61. Cell Death Dis. 2011 Oct 20;2:e219 - PubMed
  62. Biomolecules. 2014 Jul 17;4(3):704-24 - PubMed
  63. Lancet. 2003 Aug 9;362(9382):469-76 - PubMed
  64. Respir Physiol Neurobiol. 2002 Aug 22;132(1):17-41 - PubMed
  65. FASEB J. 1999 Nov;13(14 ):2061-70 - PubMed
  66. Fibrogenesis Tissue Repair. 2012 May 07;5(1):7 - PubMed
  67. Nutr Rev. 2016 Mar;74(3):181-97 - PubMed
  68. Semin Immunol. 2011 Apr;23(2):92-8 - PubMed
  69. Ann Rheum Dis. 2016 Jan;75(1):3-15 - PubMed
  70. Inflamm Allergy Drug Targets. 2007 Jun;6(2):91-100 - PubMed
  71. Nat Rev Immunol. 2005 Oct;5(10):749-59 - PubMed
  72. J Biol Chem. 1999 Jul 16;274(29):20049-52 - PubMed
  73. Autoimmune Dis. 2012;2012:836519 - PubMed
  74. CA Cancer J Clin. 2015 Mar;65(2):87-108 - PubMed
  75. Crit Care Med. 1997 Oct;25(10):1727-32 - PubMed
  76. Apoptosis. 2000 Nov;5(5):415-8 - PubMed
  77. Arthritis Res Ther. 2009;11(4):R130 - PubMed
  78. Clin Exp Immunol. 2007 Feb;147(2):227-35 - PubMed
  79. Ann Rheum Dis. 1990 Feb;49(2):128-32 - PubMed
  80. Genomics Proteomics Bioinformatics. 2015 Apr;13(2):119-26 - PubMed
  81. Cancer Res. 2007 Mar 15;67(6):2559-67 - PubMed
  82. Pharmacogn Rev. 2010 Jul;4(8):118-26 - PubMed
  83. Cancer Res. 2010 Nov 15;70(22):8988-93 - PubMed
  84. Lancet. 2016 Oct 8;388(10053):1459-1544 - PubMed
  85. Pulm Pharmacol Ther. 2001;14(6):409-20 - PubMed
  86. Clin Microbiol Rev. 1999 Jan;12(1):19-39 - PubMed
  87. J Biol Chem. 1998 Mar 13;273(11):6488-94 - PubMed
  88. Indian J Microbiol. 2011 Jun;51(2):124-31 - PubMed
  89. Front Immunol. 2016 Mar 01;7:75 - PubMed
  90. J Hematol Oncol. 2009 Jan 30;2:5 - PubMed
  91. Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1194-207 - PubMed
  92. Cancer Res. 2013 May 15;73(10 ):3109-19 - PubMed
  93. Clin Cancer Res. 2004 Nov 15;10(22):7671-6 - PubMed
  94. Clin Exp Allergy. 1998 May;28(5):527-9 - PubMed
  95. J Appl Physiol (1985). 2015 Apr 15;118(8):996-1005 - PubMed
  96. Nat Cell Biol. 2001 Sep;3(9):839-43 - PubMed
  97. J Cell Sci. 2004 Jun 1;117(Pt 13):2641-51 - PubMed
  98. Protein Pept Lett. 2009;16(6):606-12 - PubMed
  99. Oncotarget. 2010 Oct;1(6):396-404 - PubMed
  100. Crit Care Med. 2007 Sep;35(9):2128-38 - PubMed
  101. Nat Rev Immunol. 2002 Mar;2(3):185-94 - PubMed
  102. J Cell Sci. 2016 Apr 15;129(8):1661-70 - PubMed
  103. Infect Immun. 1999 Aug;67(8):4191-200 - PubMed
  104. J Biol Chem. 2003 Jul 25;278(30):27828-35 - PubMed
  105. J Exp Clin Cancer Res. 2011 Sep 26;30:87 - PubMed
  106. Mol Biosyst. 2013 Jun;9(6):1127-38 - PubMed
  107. Toxicol Pathol. 2007 Jun;35(4):495-516 - PubMed
  108. Exerc Immunol Rev. 2003;9:25-33 - PubMed
  109. Mol Cell Proteomics. 2008 Jun;7(6):1099-110 - PubMed
  110. Arthritis Care Res. 1997 Oct;10(5):283-8 - PubMed
  111. Blood. 2004 Mar 1;103(5):1747-54 - PubMed
  112. Am J Respir Cell Mol Biol. 1995 Dec;13(6):683-91 - PubMed
  113. Respirology. 2000 Sep;5(3):227-30 - PubMed
  114. Clin Chest Med. 2006 Mar;27(1):53-69, vi - PubMed
  115. Am J Physiol. 1997 Jul;273(1 Pt 1):L1-9 - PubMed
  116. Int J Mol Sci. 2011 Jan 13;12(1):334-52 - PubMed
  117. J Cell Sci. 1993 Apr;104 ( Pt 4):1091-100 - PubMed
  118. Protein Pept Lett. 2012 Jun 1;19(6):616-24 - PubMed
  119. Thorax. 2009 Feb;64(2):93-5 - PubMed
  120. ScientificWorldJournal. 2010 Aug 03;10:1543-52 - PubMed
  121. Free Radic Biol Med. 2003 Jun 15;34(12):1507-16 - PubMed
  122. PLoS One. 2011;6(11):e27205 - PubMed
  123. J Clin Invest. 1998 Jul 15;102(2):302-11 - PubMed
  124. Pharmaceuticals (Basel). 2015 Apr 02;8(2):151-75 - PubMed
  125. EMBO J. 1999 Apr 15;18(8):2040-8 - PubMed
  126. Cell. 2003 May 2;113(3):369-81 - PubMed
  127. Cell Mol Life Sci. 2005 Mar;62(6):670-84 - PubMed
  128. Cancer Lett. 2015 May 1;360(2):114-8 - PubMed
  129. J Clin Invest. 2010 Feb;120(2):457-71 - PubMed
  130. Am J Respir Cell Mol Biol. 2008 Nov;39(5):509-13 - PubMed
  131. Cell Stress Chaperones. 2012 Mar;17(2):139-43 - PubMed
  132. Free Radic Biol Med. 1990;9(3):235-43 - PubMed
  133. J Exerc Rehabil. 2016 Aug 31;12(4):255-9 - PubMed

Publication Types