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Prek B, Stanovnik B. The Synthesis of 7-Substituted-2,3-dihydropyrido [4,3-d]pyridazine-1,4-diones and 1,4-Dioxo-7-substituted-1,2,3,4-tetrahydropyrido[4,3-d]pyridazine 6-Oxides from Methyl Ketones. Acta Chim Slov. 2017;64(4):798-803doi: 10.17344/acsi.2017.3695.
Prek, B., & Stanovnik, B. (2017). The Synthesis of 7-Substituted-2,3-dihydropyrido [4,3-d]pyridazine-1,4-diones and 1,4-Dioxo-7-substituted-1,2,3,4-tetrahydropyrido[4,3-d]pyridazine 6-Oxides from Methyl Ketones. Acta chimica Slovenica, 64(4), 798-803. https://doi.org/10.17344/acsi.2017.3695
Prek, Benjamin, and Stanovnik, Branko. "The Synthesis of 7-Substituted-2,3-dihydropyrido [4,3-d]pyridazine-1,4-diones and 1,4-Dioxo-7-substituted-1,2,3,4-tetrahydropyrido[4,3-d]pyridazine 6-Oxides from Methyl Ketones." Acta chimica Slovenica vol. 64,4 (2017): 798-803. doi: https://doi.org/10.17344/acsi.2017.3695
Prek B, Stanovnik B. The Synthesis of 7-Substituted-2,3-dihydropyrido [4,3-d]pyridazine-1,4-diones and 1,4-Dioxo-7-substituted-1,2,3,4-tetrahydropyrido[4,3-d]pyridazine 6-Oxides from Methyl Ketones. Acta Chim Slov. 2017 Dec;64(4):798-803. doi: 10.17344/acsi.2017.3695. PMID: 29318308.
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Acta Chim Slov. 2017 Dec;64(4):798-803. doi: 10.17344/acsi.2017.3695.

The Synthesis of 7-Substituted-2,3-dihydropyrido [4,3-d]pyridazine-1,4-diones and 1,4-Dioxo-7-substituted-1,2,3,4-tetrahydropyrido[4,3-d]pyridazine 6-Oxides from Methyl Ketones.

Acta chimica Slovenica

Benjamin Prek, Branko Stanovnik

PMID: 29318308 DOI: 10.17344/acsi.2017.3695

Abstract

A general four-step transformation of alkyl, cycloalkyl, aryl, and heteroaryl methyl ketones via 3-(dimethylamino)-1-substituted-prop-2-en-1-ones, followed by microwave [2+2] cycloaddition of dimethyl acetylenedicarboxylate, cyclization of (2E,3E)-2-[(dimethylamino)methylene]-3-(2-substituted)succinates with ammonia or hydroxylamine hydrochloride into 2-substituted-pyridine-4,5-dicarboxylates and their N-oxides and final cyclization with hydrazine hydrate into of 7-substituted-2,3-dihydropyrido[3,4-d]pyridazine-1,4-diones and 1,4-dioxo-7-substituted-1,2,3,4-tetrahydropyrido[4,3-d]pyridazine 6-oxides is shown.

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