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Park SW, Jee SR, Kim JH, et al. Duodenal amyloidosis secondary to ulcerative colitis. Intest Res. 2018;16(1):151-154doi: 10.5217/ir.2018.16.1.151.
Park, S. W., Jee, S. R., Kim, J. H., Lee, S. H., Hwang, J. W., Jang, J. G., Lee, D. W., & Seol, S. Y. (2018). Duodenal amyloidosis secondary to ulcerative colitis. Intestinal research, 16(1), 151-154. https://doi.org/10.5217/ir.2018.16.1.151
Park, Seung Woon, et al. "Duodenal amyloidosis secondary to ulcerative colitis." Intestinal research vol. 16,1 (2018): 151-154. doi: https://doi.org/10.5217/ir.2018.16.1.151
Park SW, Jee SR, Kim JH, Lee SH, Hwang JW, Jang JG, Lee DW, Seol SY. Duodenal amyloidosis secondary to ulcerative colitis. Intest Res. 2018 Jan;16(1):151-154. doi: 10.5217/ir.2018.16.1.151. Epub 2018 Jan 18. PMID: 29422811; PMCID: PMC5797263.
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Intest Res. 2018 Jan;16(1):151-154. doi: 10.5217/ir.2018.16.1.151. Epub 2018 Jan 18.

Duodenal amyloidosis secondary to ulcerative colitis.

Intestinal research

Seung Woon Park, Sam Ryong Jee, Ji Hyun Kim, Sang Heon Lee, Jin Won Hwang, Ji Geon Jang, Dong Woo Lee, Sang Yong Seol

Affiliations

  1. Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

PMID: 29422811 PMCID: PMC5797263 DOI: 10.5217/ir.2018.16.1.151

Abstract

Amyloidosis is defined as the extracellular deposition of non-branching fibrils composed of a variety of serum-protein precursors. Secondary amyloidosis is associated with several chronic inflammatory conditions, such as rheumatologic or intestinal diseases, familial Mediterranean fever, or chronic infectious diseases, such as tuberculosis. Although the association of amyloidosis with inflammatory bowel disease is known, amyloidosis secondary to ulcerative colitis (UC) is rare. A 36-year-old male patient with a 15-year history of UC presented with nausea, vomiting, and abdominal pain. He had been treated with infliximab for 6 years. At the time of admission, he had been undergoing treatment with mesalazine and adalimumab since the preceding 5 months. Esophagogastroduodenoscopy showed mucosal erythema, edema, and erosions with geographic ulcers at the 2nd and 3rd portions of the duodenum. Duodenal amyloidosis was diagnosed using polarized light microscopy and Congo red stain. Monoclonal gammopathy was not detected in serum and urine tests, while the serum free light chain assay result was not specific. An increase in plasma cells in the bone marrow was not found. Secondary amyloidosis due to UC was suspected. The symptoms were resolved after glucocorticoid therapy.

Keywords: Amyloidosis; Colitis, ulcerative; Duodenum

Conflict of interest statement

CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported.

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