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Muhammad N, Sharif M, Amin J, et al. Neurochemical Alterations in Sudden Unexplained Perinatal Deaths-A Review. Front Pediatr. 2018;6:6doi: 10.3389/fped.2018.00006.
Muhammad, N., Sharif, M., Amin, J., Mehboob, R., Gilani, S. A., Bibi, N., Javed, H., & Ahmed, N. (2018). Neurochemical Alterations in Sudden Unexplained Perinatal Deaths-A Review. Frontiers in pediatrics, 66. https://doi.org/10.3389/fped.2018.00006
Muhammad, Nazeer, et al. "Neurochemical Alterations in Sudden Unexplained Perinatal Deaths-A Review." Frontiers in pediatrics vol. 6 (2018): 6. doi: https://doi.org/10.3389/fped.2018.00006
Muhammad N, Sharif M, Amin J, Mehboob R, Gilani SA, Bibi N, Javed H, Ahmed N. Neurochemical Alterations in Sudden Unexplained Perinatal Deaths-A Review. Front Pediatr. 2018 Jan 25;6:6. doi: 10.3389/fped.2018.00006. eCollection 2018. PMID: 29423392; PMCID: PMC5788892.
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Front Pediatr. 2018 Jan 25;6:6. doi: 10.3389/fped.2018.00006. eCollection 2018.

Neurochemical Alterations in Sudden Unexplained Perinatal Deaths-A Review.

Frontiers in pediatrics

Nazeer Muhammad, Muhammad Sharif, Javeria Amin, Riffat Mehboob, Syed Amir Gilani, Nargis Bibi, Hasnain Javed, Naseer Ahmed

Affiliations

  1. COMSATS Institute of Information Technology, Wah Cantonment, Pakistan.
  2. Research Unit, Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan.
  3. University Institute of Physical Therapy, Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan.
  4. Department of Computer Sciences, Fatima Jinnah Women University, Rawalpindi, Pakistan.
  5. Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.
  6. Medical School, University of Verona, Verona, Italy.
  7. Faculty of Health Sciences, University of the Punjab, Lahore, Pakistan.

PMID: 29423392 PMCID: PMC5788892 DOI: 10.3389/fped.2018.00006

Abstract

Sudden unexpected perinatal collapse is a major trauma for the parents of victims. Sudden infant death syndrome (SIDS) is unexpected and mysterious death of an apparently healthy neonate from birth till 1 year of age without any known causes, even after thorough postmortem investigations. However, the incidence of sudden intrauterine unexplained death syndrome (SIUDS) is seven times higher as compared with SIDS. This observation is approximated 40-80%. Stillbirth is defined as death of a fetus after 20th week of gestation or just before delivery at full term without a known reason. Pakistan has the highest burden of stillbirth in the world. This basis of SIDS, SIUDS, and stillbirths eludes specialists. The purpose of this study is to investigate factors behind failure in control of these unexplained deaths and how research may go ahead with improved prospects. Animal models and physiological data demonstrate that sleep, arousal, and cardiorespiratory malfunctioning are abnormal mechanisms in SIUDS risk factors or in newborn children who subsequently die from SIDS. This review focuses on insights in neuropathology and mechanisms of SIDS and SIUDS in terms of different receptors involved in this major perinatal demise. Several studies conducted in the past decade have confirmed neuropathological and neurochemical anomalies related to serotonin transporter, substance P, acetylcholine α7 nicotine receptors, etc., in sudden unexplained fetal and infant deaths. There is need to focus more on research in this area to unveil the major curtain to neuroprotection by underlying mechanisms leading to such deaths.

Keywords: neurochemicals; neuropathology; stillbirth; sudden infant death; sudden intrauterine death; sudden perinatal death

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