Hosp Pediatr. 2018 Jan 23; doi: 10.1542/hpeds.2017-0120. Epub 2018 Jan 23.
Use of Intranasal Dexmedetomidine as a Solo Sedative for MRI of Infants.
Hospital pediatrics
Gokhan Olgun, Mir Hyder Ali
Affiliations
Affiliations
- Sanford Children's Hospital, Sioux Falls, South Dakota; and [email protected].
- Department of Pediatric Intensive Care Medicine, University of South Dakota, Vermillion, South Dakota.
- Sanford Children's Hospital, Sioux Falls, South Dakota; and.
PMID: 29363517
DOI: 10.1542/hpeds.2017-0120
Abstract
BACKGROUND: Dexmedetomidine, a selective α-2 receptor agonist, can be delivered via the intranasal (IN) route and be used for procedural sedation. The drug's favorable hemodynamic profile and relative ease of application make it a promising agent for sedation during radiologic procedures, although there are few studies on its efficacy for MRI studies.
METHODS: A retrospective chart review was performed between June 2014 and December 2016. Outpatients between 1 and 12 months of age who received 4 μg/kg of IN dexmedetomidine for MRI were included in the analysis. Our aim with this study was to determine the rate of successful completion of the sedation procedure without the need for a rescue drug (other than repeat IN dexmedetomidine).
RESULTS: A total of 52 subjects were included in our study. Median (interquartile range) patient age was 7 (5-8) months. Median (interquartile range) procedure length was 40 (35-50) minutes. Overall success rate (including first dose and any rescue dose IN) of dexmedetomidine was 96.2%. None of the patients had significant adverse effects related to dexmedetomidine.
CONCLUSIONS: IN dexmedetomidine is an effective solo sedative agent for MRI in infants.
Copyright © 2018 by the American Academy of Pediatrics.
Conflict of interest statement
POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.
Publication Types
