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Choquet C, Marcadet L, Beyer S, et al. Segregation of Central Ventricular Conduction System Lineages in Early SMA+ Cardiomyocytes Occurs Prior to Heart Tube Formation. J Cardiovasc Dev Dis. 2016;3(1)doi: 10.3390/jcdd3010002.
Choquet, C., Marcadet, L., Beyer, S., Kelly, R. G., & Miquerol, L. (2016). Segregation of Central Ventricular Conduction System Lineages in Early SMA+ Cardiomyocytes Occurs Prior to Heart Tube Formation. Journal of cardiovascular development and disease, 3(1), . https://doi.org/10.3390/jcdd3010002
Choquet, Caroline, et al. "Segregation of Central Ventricular Conduction System Lineages in Early SMA+ Cardiomyocytes Occurs Prior to Heart Tube Formation." Journal of cardiovascular development and disease vol. 3,1 (2016). doi: https://doi.org/10.3390/jcdd3010002
Choquet C, Marcadet L, Beyer S, Kelly RG, Miquerol L. Segregation of Central Ventricular Conduction System Lineages in Early SMA+ Cardiomyocytes Occurs Prior to Heart Tube Formation. J Cardiovasc Dev Dis. 2016 Jan 21;3(1). doi: 10.3390/jcdd3010002. PMID: 29367554; PMCID: PMC5715695.
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J Cardiovasc Dev Dis. 2016 Jan 21;3(1). doi: 10.3390/jcdd3010002.

Segregation of Central Ventricular Conduction System Lineages in Early SMA+ Cardiomyocytes Occurs Prior to Heart Tube Formation.

Journal of cardiovascular development and disease

Caroline Choquet, Laetitia Marcadet, Sabrina Beyer, Robert G Kelly, Lucile Miquerol

Affiliations

  1. Aix-Marseille Université, CNRS UMR 7288, Developmental Biology Institute of Marseille, Campus de Luminy Case 907, 13288 Marseille Cedex 9, France. [email protected].
  2. Aix-Marseille Université, CNRS UMR 7288, Developmental Biology Institute of Marseille, Campus de Luminy Case 907, 13288 Marseille Cedex 9, France. [email protected].
  3. Aix-Marseille Université, CNRS UMR 7288, Developmental Biology Institute of Marseille, Campus de Luminy Case 907, 13288 Marseille Cedex 9, France. [email protected].
  4. Aix-Marseille Université, CNRS UMR 7288, Developmental Biology Institute of Marseille, Campus de Luminy Case 907, 13288 Marseille Cedex 9, France. [email protected].
  5. Aix-Marseille Université, CNRS UMR 7288, Developmental Biology Institute of Marseille, Campus de Luminy Case 907, 13288 Marseille Cedex 9, France. [email protected].

PMID: 29367554 PMCID: PMC5715695 DOI: 10.3390/jcdd3010002

Abstract

The cardiac conduction system (CCS) transmits electrical activity from the atria to the ventricles to coordinate heartbeats. Atrioventricular conduction diseases are often associated with defects in the central ventricular conduction system comprising the atrioventricular bundle (AVB) and right and left branches (BBs). Conducting and contractile working myocytes share common cardiomyogenic progenitors, however the time at which the CCS lineage becomes specified is unclear. In order to study the fate and the contribution to the CCS of cardiomyocytes during early heart tube formation, we performed a genetic lineage analysis using a

Keywords: atrioventricular bundle; bundle branches; cardiac conduction system; cardiac development; clonal analysis; fate mapping; heart tube; smooth muscle actin

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