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Hayashi M, Kawana S, Sekino H, et al. Contrast uptake in primary hepatic angiosarcoma on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging in the hepatobiliary phase. World J Hepatol. 2018;10(1):166-171doi: 10.4254/wjh.v10.i1.166.
Hayashi, M., Kawana, S., Sekino, H., Abe, K., Matsuoka, N., Kashiwagi, M., Okai, K., Kanno, Y., Takahashi, A., Ito, H., Hashimoto, Y., & Ohira, H. (2018). Contrast uptake in primary hepatic angiosarcoma on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging in the hepatobiliary phase. World journal of hepatology, 10(1), 166-171. https://doi.org/10.4254/wjh.v10.i1.166
Hayashi, Manabu, et al. "Contrast uptake in primary hepatic angiosarcoma on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging in the hepatobiliary phase." World journal of hepatology vol. 10,1 (2018): 166-171. doi: https://doi.org/10.4254/wjh.v10.i1.166
Hayashi M, Kawana S, Sekino H, Abe K, Matsuoka N, Kashiwagi M, Okai K, Kanno Y, Takahashi A, Ito H, Hashimoto Y, Ohira H. Contrast uptake in primary hepatic angiosarcoma on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging in the hepatobiliary phase. World J Hepatol. 2018 Jan 27;10(1):166-171. doi: 10.4254/wjh.v10.i1.166. PMID: 29399290; PMCID: PMC5787680.
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World J Hepatol. 2018 Jan 27;10(1):166-171. doi: 10.4254/wjh.v10.i1.166.

Contrast uptake in primary hepatic angiosarcoma on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging in the hepatobiliary phase.

World journal of hepatology

Manabu Hayashi, Satoshi Kawana, Hirofumi Sekino, Kazumichi Abe, Naoki Matsuoka, Masahito Kashiwagi, Ken Okai, Yukiko Kanno, Atsushi Takahashi, Hiroshi Ito, Yuko Hashimoto, Hiromasa Ohira

Affiliations

  1. Department of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
  2. Department of Diagnostic Pathology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
  3. Department of Radiology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.

PMID: 29399290 PMCID: PMC5787680 DOI: 10.4254/wjh.v10.i1.166

Abstract

Primary hepatic angiosarcoma is the most common malignant mesenchymal tumor of the liver. It has a poor prognosis and various appearances on magnetic resonance (MR) images. We report a case of hepatic angiosarcoma with a characteristic appearance on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging in the hepatobiliary phase. A 72-year-old man was admitted with a complaint of abdominal pain. Gd-EOB-DTPA-enhanced MR imaging revealed a liver tumor that showed slight hyperintensity in the hepatobiliary phase. These findings suggested Gd-EOB-DTPA uptake in the tumor. An autopsy revealed the solid proliferation and sinusoidal spreading of hepatic angiosarcoma cells. Immunohistochemistry indicated that the tumor was negative for OATP1B3. Gd-EOB-DTPA uptake in the liver tumor in the hepatobiliary phase suggested sinusoidal tumor invasion with residual normal hepatocytes.

Keywords: Cirrhosis; Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid; Hepatic angiosarcoma; Hepatocellular carcinoma

Conflict of interest statement

Conflict-of-interest statement: There are no conflicts of interest to declare.

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