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F1000Res. 2018 Jan 17;7:82. doi: 10.12688/f1000research.13167.1. eCollection 2018.

JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders.

F1000Research

William Vainchenker, Emilie Leroy, Laure Gilles, Caroline Marty, Isabelle Plo, Stefan N Constantinescu

Affiliations

  1. INSERM UMR 1170, Gustave Roussy, Villejuif, France.
  2. Université Paris-Saclay, UMR1170, Gustave Roussy, Villejuif, France.
  3. UMR 1170, Gustave Roussy, Villejuif, France.
  4. Signal Transduction & Molecular Hematology Unit, Ludwig Institute for Cancer Research, Brussels, Belgium.
  5. de Duve Institute, Université catholique de Louvain, Brussels, Belgium.
  6. Institut National de la Transfusion Sanguine, Paris, France.

PMID: 29399328 PMCID: PMC5773931 DOI: 10.12688/f1000research.13167.1

Abstract

JAK inhibitors have been developed following the discovery of the

Keywords: JAK inhibitors; MPN; allosteric inhibitor; auto-immune diseases; inflammation

Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

References

  1. Blood. 2017 Feb 9;129(6):667-679 - PubMed
  2. N Engl J Med. 2013 May 9;368(19):1781-90 - PubMed
  3. Nature. 2010 Jan 28;463(7280):501-6 - PubMed
  4. J Exp Med. 2009 Aug 3;206(8):1701-7 - PubMed
  5. Rheumatology (Oxford). 2017 Dec 1;56(12):e49 - PubMed
  6. Oncotarget. 2015 Jul 10;6(19):17764-76 - PubMed
  7. J Am Acad Dermatol. 2016 Dec;75(6):1162-1170.e3 - PubMed
  8. Blood. 2009 Aug 20;114(8):1628-32 - PubMed
  9. J Dermatolog Treat. 2016 Aug;27(4):332-8 - PubMed
  10. Neurosci Lett. 2017 Mar 6;642:163-167 - PubMed
  11. Blood. 2017 Oct 26;130(17):1889-1897 - PubMed
  12. Leukemia. 2015 Oct;29(10):2062-8 - PubMed
  13. Ann Rheum Dis. 2016 Jun;75(6):1057-64 - PubMed
  14. Blood Cancer J. 2015 Aug 07;5:e335 - PubMed
  15. Leuk Lymphoma. 2015 Jul;56(7):2092-7 - PubMed
  16. J Hematol Oncol. 2016 Dec 8;9(1):137 - PubMed
  17. Blood. 2016 Jul 7;128(1):144-5 - PubMed
  18. Annu Rev Immunol. 1995;13:369-98 - PubMed
  19. N Engl J Med. 2012 Mar 1;366(9):787-98 - PubMed
  20. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7 - PubMed
  21. N Engl J Med. 2012 Mar 1;366(9):844-6 - PubMed
  22. Crit Rev Oncog. 2011;16(1-2):13-24 - PubMed
  23. Leukemia. 2008 May;22(5):965-70 - PubMed
  24. Nat Genet. 2013 Nov;45(11):1293-9 - PubMed
  25. Leukemia. 2012 Apr;26(4):708-15 - PubMed
  26. Biochem J. 2016 Jun 1;473(11):1579-91 - PubMed
  27. J Biol Chem. 2005 Jul 22;280(29):27251-61 - PubMed
  28. Arthritis Res Ther. 2011 Apr 21;13(2):R68 - PubMed
  29. Front Endocrinol (Lausanne). 2017 Sep 12;8:234 - PubMed
  30. Haematologica. 2017 Feb;102(2):327-335 - PubMed
  31. Best Pract Res Clin Haematol. 2014 Jun;27(2):95-106 - PubMed
  32. Blood. 2012 May 17;119(20):4614-8 - PubMed
  33. Blood. 2014 May 29;123(22):e123-33 - PubMed
  34. PLoS One. 2015 Jul 01;10(7):e0130078 - PubMed
  35. Leukemia. 2018 Apr;32(4):1035-1038 - PubMed
  36. Expert Opin Pharmacother. 2017 Sep;18(13):1399-1407 - PubMed
  37. J Clin Invest. 2010 Oct;120(10):3578-93 - PubMed
  38. Blood. 2016 Mar 10;127(10):1307-16 - PubMed
  39. Blood Cancer J. 2011 Jul;1(7):e29 - PubMed
  40. Hematology Am Soc Hematol Educ Program. 2012;2012:389-96 - PubMed
  41. Blood. 2010 Aug 12;116(6):988-92 - PubMed
  42. Nat Rev Rheumatol. 2016 Jan;12(1):25-36 - PubMed
  43. Blood. 2012 Mar 22;119(12):2721-30 - PubMed
  44. Leukemia. 2014 Nov;28(11):2139-47 - PubMed
  45. Oncotarget. 2013 Jul;4(7):954-5 - PubMed
  46. Cancer Cell. 2011 Feb 15;19(2):283-94 - PubMed
  47. Ann Rheum Dis. 2017 Nov;76(11):1853-1861 - PubMed
  48. Leukemia. 2014 Sep;28(9):1804-10 - PubMed
  49. Blood. 2010 Feb 4;115(5):1006-17 - PubMed
  50. Cancer Cell. 2016 Feb 8;29(2):186-200 - PubMed
  51. Blood. 2016 Mar 10;127(10):1317-24 - PubMed
  52. Haematologica. 2016 Sep;101(9):1065-73 - PubMed
  53. Br J Dermatol. 2015 Sep;173(3):767-76 - PubMed
  54. Leuk Res. 2017 Sep;60:11-17 - PubMed
  55. Leuk Res. 2015 Sep;39(9):950-6 - PubMed
  56. Leuk Res. 2017 Feb;53:13-19 - PubMed
  57. Chem Biol. 2011 Mar 25;18(3):314-23 - PubMed
  58. Expert Opin Ther Pat. 2015;25(12):1397-421 - PubMed
  59. Nature. 2009 Oct 8;461(7265):819-22 - PubMed
  60. Leuk Res. 2015 Feb;39(2):157-63 - PubMed
  61. Immunotherapy. 2018 Jan;10(1):39-56 - PubMed
  62. Br J Dermatol. 2018 Jul;179(1):54-62 - PubMed
  63. Cancer Res. 2005 Apr 1;65(7):2662-7 - PubMed
  64. Ann Rheum Dis. 2016 Nov;75(11):1979-1983 - PubMed
  65. Biochem Soc Trans. 2013 Aug;41(4):1002-7 - PubMed
  66. PLoS One. 2014 Sep 08;9(9):e106225 - PubMed
  67. Clin Exp Dermatol. 2017 Dec;42(8):942-944 - PubMed
  68. Leuk Res. 2017 Oct;61:89-95 - PubMed
  69. J Exp Med. 2016 Aug 22;213(9):1723-40 - PubMed
  70. Cancer Discov. 2012 Jun;2(6):512-523 - PubMed
  71. Blood. 2011 Apr 14;117(15):4056-64 - PubMed
  72. Leukemia. 2017 May;31(5):1023-1038 - PubMed
  73. Mol Cancer Ther. 2015 Feb;14(2):364-74 - PubMed
  74. Nat Genet. 2014 Apr;46(4):329-35 - PubMed
  75. J Clin Oncol. 2017 Dec 1;35(34):3844-3850 - PubMed
  76. Genes Cancer. 2010 Apr;1(4):331-45 - PubMed
  77. Nature. 2012 Sep 6;489(7414):155-9 - PubMed
  78. N Engl J Med. 2012 Mar 1;366(9):799-807 - PubMed
  79. Blood. 2012 Nov 8;120(19):4093-103 - PubMed
  80. Immunotherapy. 2016 May;8(5):495-502 - PubMed
  81. J Exp Med. 2008 Apr 14;205(4):751-8 - PubMed
  82. Cancer J. 2014 Jan-Feb;20(1):61-5 - PubMed
  83. Cancer Res. 2015 Jun 1;75(11):2187-99 - PubMed
  84. J Thorac Oncol. 2017 Jan;12(1):102-109 - PubMed
  85. Trends Endocrinol Metab. 1999 Dec;10(1):18-23 - PubMed
  86. Ann Hematol. 2015 Nov;94(11):1927-8 - PubMed
  87. Leuk Res. 2014 Mar;38(3):316-22 - PubMed
  88. Eur J Immunol. 2017 Jul;47(7):1096-1107 - PubMed
  89. Br J Dermatol. 2016 Jun;174(6):1266-76 - PubMed
  90. N Engl J Med. 2015 Feb 12;372(7):601-612 - PubMed
  91. N Engl J Med. 2015 Jan 29;372(5):426-35 - PubMed
  92. Cell Stem Cell. 2017 Oct 5;21(4):489-501.e7 - PubMed
  93. Acta Haematol. 2014;132(1):75-86 - PubMed
  94. Leukemia. 2017 Feb;31(2):393-402 - PubMed
  95. Blood. 2017 Oct 12;130(15):1768-1771 - PubMed
  96. J Med Chem. 2014 Jun 26;57(12):5023-38 - PubMed
  97. J Clin Oncol. 2015 Dec 1;33(34):4039-47 - PubMed
  98. J Am Acad Dermatol. 2016 Feb;74(2):370-1 - PubMed
  99. Leukemia. 2014 Feb;28(2):417-9 - PubMed
  100. Cell Stem Cell. 2017 Jun 1;20(6):785-800.e8 - PubMed
  101. J Biol Chem. 2008 May 9;283(19):12941-8 - PubMed
  102. Lancet Oncol. 2017 Jan;18(1):88-99 - PubMed
  103. Nat Genet. 2009 Nov;41(11):1243-6 - PubMed
  104. Blood. 2007 Mar 1;109(5):2202-4 - PubMed
  105. J Hematol Oncol. 2017 Sep 29;10(1):156 - PubMed
  106. Ann Rheum Dis. 2018 Feb;77(2):175-187 - PubMed
  107. Drug Metab Dispos. 2014 Oct;42(10):1656-62 - PubMed
  108. J Biol Chem. 2008 Feb 29;283(9):5258-66 - PubMed
  109. Nat Rev Rheumatol. 2017 Apr;13(4):234-243 - PubMed
  110. Nature. 2011 Feb 3;470(7332):115-9 - PubMed
  111. Annu Rev Pathol. 2016 May 23;11:101-26 - PubMed
  112. Arthritis Rheumatol. 2015 Feb;67(2):334-43 - PubMed
  113. Cancer Discov. 2016 Apr;6(4):368-81 - PubMed
  114. Arthritis Rheumatol. 2017 Oct;69(10):1949-1959 - PubMed
  115. Blood. 2017 Jul 13;130(2):115-125 - PubMed
  116. Haematologica. 2017 Jan;102(1):94-102 - PubMed
  117. Am J Hematol. 2017 Mar;92(3):297-310 - PubMed
  118. N Engl J Med. 2010 Sep 16;363(12):1189-90 - PubMed
  119. Cancer Cell. 2010 Dec 14;18(6):590-605 - PubMed
  120. Nat Med. 2014 Apr;20(4):398-407 - PubMed
  121. Leukemia. 2015 Mar;29(3):741-4 - PubMed
  122. Semin Immunol. 1995 Aug;7(4):247-54 - PubMed
  123. N Engl J Med. 2013 Dec 19;369(25):2391-2405 - PubMed
  124. Anticancer Agents Med Chem. 2013 Jun;13(5):731-47 - PubMed
  125. Exp Hematol Oncol. 2015 Sep 15;4:26 - PubMed
  126. Blood. 2002 Jun 1;99(11):4192-9 - PubMed
  127. Exp Mol Pathol. 2006 Dec;81(3):217-23 - PubMed
  128. Blood. 2008 Nov 15;112(10):4220-6 - PubMed
  129. Mol Cancer Ther. 2010 Jul;9(7):1945-55 - PubMed
  130. Blood. 2014 Jun 12;123(24):3832-42 - PubMed
  131. Gut. 2017 Jun;66(6):1049-1059 - PubMed
  132. Mol Cancer Ther. 2008 May;7(5):1176-84 - PubMed
  133. Nat Struct Mol Biol. 2013 Oct;20(10):1221-3 - PubMed
  134. Leuk Res Rep. 2014 Aug 01;3(2):67-9 - PubMed
  135. Lancet Haematol. 2017 May;4(5):e225-e236 - PubMed
  136. J Cell Mol Med. 2013 Nov;17(11):1397-409 - PubMed
  137. Oncologist. 2013;18(7):819-20 - PubMed
  138. Blood. 1997 Oct 1;90(7):2535-40 - PubMed
  139. Blood. 2016 Mar 10;127(10):1325-35 - PubMed
  140. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9414-8 - PubMed
  141. Cancer Immunol Res. 2017 Jan;5(1):52-60 - PubMed
  142. Expert Rev Hematol. 2017 May;10(5):393-404 - PubMed
  143. Haematologica. 2018 Jan;103(1):e5-e9 - PubMed
  144. Cancer Cell. 2015 Jul 13;28(1):29-41 - PubMed
  145. Blood. 2012 Aug 16;120(7):1529-31 - PubMed
  146. Drug News Perspect. 2010 Jun;23(5):305-15 - PubMed
  147. J Am Acad Dermatol. 2012 Oct;67(4):658-64 - PubMed
  148. Mol Cell. 2001 Dec;8(6):1327-38 - PubMed
  149. Genes Chromosomes Cancer. 2005 Nov;44(3):329-33 - PubMed
  150. N Engl J Med. 2013 Dec 19;369(25):2379-90 - PubMed
  151. Oncogene. 2016 Feb 25;35(8):939-51 - PubMed
  152. Oncogene. 2013 May 23;32(21):2601-13 - PubMed
  153. Ann Hematol. 2015 Feb;94(2):233-8 - PubMed
  154. J Exp Med. 2016 Jul 25;213(8):1479-96 - PubMed
  155. Cancer Cell. 2015 Jul 13;28(1):15-28 - PubMed
  156. Lancet. 2017 Jan 21;389(10066):266-275 - PubMed
  157. Clin Pharmacokinet. 2018 Aug;57(8):977-988 - PubMed
  158. Front Endocrinol (Lausanne). 2017 Apr 18;8:71 - PubMed
  159. Leukemia. 2007 Aug;21(8):1658-68 - PubMed
  160. Clin Cancer Res. 2014 Apr 15;20(8):2051-9 - PubMed
  161. Lancet Haematol. 2017 Jul;4(7):e317-e324 - PubMed
  162. J Biol Chem. 2009 Mar 13;284(11):6773-81 - PubMed
  163. Mayo Clin Proc. 2017 Aug;92(8):1283-1290 - PubMed
  164. N Engl J Med. 2009 May 28;360(22):2289-301 - PubMed
  165. J Transl Med. 2015 Sep 10;13:294 - PubMed
  166. Haematologica. 2011 Jun;96(6):845-53 - PubMed
  167. Blood. 2017 Mar 30;129(13):1823-1830 - PubMed
  168. Expert Rev Hematol. 2017 Jul;10(7):617-625 - PubMed
  169. J Cell Mol Med. 2013 Nov;17(11):1385-96 - PubMed
  170. JAMA Oncol. 2015 Aug;1(5):643-51 - PubMed
  171. JCI Insight. 2016 Sep 22;1(15):e89790 - PubMed
  172. ACS Med Chem Lett. 2017 May 17;8(6):618-621 - PubMed
  173. J Exp Med. 2011 May 9;208(5):901-8 - PubMed
  174. Future Oncol. 2018 Jan;14(2):137-150 - PubMed
  175. Expert Opin Pharmacother. 2017 Oct;18(15):1557-1567 - PubMed
  176. Nat Struct Mol Biol. 2012 Aug;19(8):754-9 - PubMed
  177. F1000Res. 2016 Apr 19;5: - PubMed

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