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Shchelkunova GA, Shchelkunov SN. 40 Years without Smallpox. Acta Naturae. 2017;9(4):4-12
Shchelkunova, G. A., & Shchelkunov, S. N. (2017). 40 Years without Smallpox. Acta naturae, 9(4), 4-12.
Shchelkunova, G A, and Shchelkunov, S N. "40 Years without Smallpox." Acta naturae vol. 9,4 (2017): 4-12.
Shchelkunova GA, Shchelkunov SN. 40 Years without Smallpox. Acta Naturae. 2017 Oct-Dec;9(4):4-12. PMID: 29340212; PMCID: PMC5762823.
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Acta Naturae. 2017 Oct-Dec;9(4):4-12.

40 Years without Smallpox.

Acta naturae

G A Shchelkunova, S N Shchelkunov

Affiliations

  1. State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Novosibirsk region, 630559 , Russia.
  2. Novosibirsk State University, Pirogov Str. 2, Novosibirsk, 630090, Russia.

PMID: 29340212 PMCID: PMC5762823

Abstract

The last case of natural smallpox was recorded in October, 1977. It took humanity almost 20 years to achieve that feat after the World Health Organization had approved the global smallpox eradication program. Vaccination against smallpox was abolished, and, during the past 40 years, the human population has managed to lose immunity not only to smallpox, but to other zoonotic orthopoxvirus infections as well. As a result, multiple outbreaks of orthopoxvirus infections in humans in several continents have been reported over the past decades. The threat of smallpox reemergence as a result of evolutionary transformations of these zoonotic orthopoxviruses exists. Modern techniques for the diagnostics, prevention, and therapy of smallpox and other orthopoxvirus infections are being developed today.

Keywords: DNA diagnostics; chemotherapeutic drugs; evolution; smallpox; vaccine; variola (smallpox) virus

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