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Bondaryk M, Staniszewska M, Zielińska P, et al. Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds. J Fungi (Basel). 2017;3(3)doi: 10.3390/jof3030046.
Bondaryk, M., Staniszewska, M., Zielińska, P., & Urbańczyk-Lipkowska, Z. (2017). Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds. Journal of fungi (Basel, Switzerland), 3(3), . https://doi.org/10.3390/jof3030046
Bondaryk, Małgorzata, et al. "Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds." Journal of fungi (Basel, Switzerland) vol. 3,3 (2017). doi: https://doi.org/10.3390/jof3030046
Bondaryk M, Staniszewska M, Zielińska P, Urbańczyk-Lipkowska Z. Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds. J Fungi (Basel). 2017 Aug 26;3(3). doi: 10.3390/jof3030046. PMID: 29371563; PMCID: PMC5715947.
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J Fungi (Basel). 2017 Aug 26;3(3). doi: 10.3390/jof3030046.

Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds.

Journal of fungi (Basel, Switzerland)

Małgorzata Bondaryk, Monika Staniszewska, Paulina Zielińska, Zofia Urbańczyk-Lipkowska

Affiliations

  1. National Institute of Public Health-National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland. [email protected].
  2. National Institute of Public Health-National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland. [email protected].
  3. Institute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland. [email protected].
  4. Institute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland. [email protected].

PMID: 29371563 PMCID: PMC5715947 DOI: 10.3390/jof3030046

Abstract

Invasive fungal infections are associated with high mortality rates, despite appropriate antifungal therapy. Limited therapeutic options, resistance development and the high mortality of invasive fungal infections brought about more concern triggering the search for new compounds capable of interfering with fungal viability and virulence. In this context, peptides gained attention as promising candidates for the antimycotics development. Variety of structural and functional characteristics identified for various natural antifungal peptides makes them excellent starting points for design novel drug candidates. Current review provides a brief overview of natural and synthetic antifungal peptides.

Keywords: Candida species; antifungal peptides; fungal pathogens

Conflict of interest statement

The authors declare no conflict of interest.

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