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Abassi M, Rhein J, Meya DB, et al. Cryptococcal Disease in the Era of "Test and Treat": Is There Cause for Concern?. Open Forum Infect Dis. 2017;5(1):ofx274doi: 10.1093/ofid/ofx274.
Abassi, M., Rhein, J., Meya, D. B., & Boulware, D. R. (2018). Cryptococcal Disease in the Era of "Test and Treat": Is There Cause for Concern?. Open forum infectious diseases, 5(1), ofx274. https://doi.org/10.1093/ofid/ofx274
Abassi, Mahsa, et al. "Cryptococcal Disease in the Era of "Test and Treat": Is There Cause for Concern?." Open forum infectious diseases vol. 5,1 (2018): ofx274. doi: https://doi.org/10.1093/ofid/ofx274
Abassi M, Rhein J, Meya DB, Boulware DR. Cryptococcal Disease in the Era of "Test and Treat": Is There Cause for Concern?. Open Forum Infect Dis. 2017 Dec 26;5(1):ofx274. doi: 10.1093/ofid/ofx274. eCollection 2018 Jan. PMID: 29372172; PMCID: PMC5777480.
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Open Forum Infect Dis. 2017 Dec 26;5(1):ofx274. doi: 10.1093/ofid/ofx274. eCollection 2018 Jan.

Cryptococcal Disease in the Era of "Test and Treat": Is There Cause for Concern?.

Open forum infectious diseases

Mahsa Abassi, Joshua Rhein, David B Meya, David R Boulware

Affiliations

  1. Infectious Diseases Institute, Kampala, Uganda.
  2. University of Minnesota, Minneapolis, Minnesota.
  3. School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.

PMID: 29372172 PMCID: PMC5777480 DOI: 10.1093/ofid/ofx274

Abstract

Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution inflammatory syndrome (IRIS). We present 3 cases where early ART initiation in the presence of unrecognized cryptococcal disease had fatal outcomes.

Keywords: HIV; cryptococcal immune reconstitution syndrome; test and treat

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