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Mol Cell Oncol. 2017 Nov 30;5(1):e1396389. doi: 10.1080/23723556.2017.1396389. eCollection 2018.

To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function.

Molecular & cellular oncology

Manoj B Menon, Julia Gropengießer, Klaus Ruckdeschel, Matthias Gaestel

Affiliations

  1. Institute of Cell Biochemistry, Hannover Medical School, Hannover, Germany.
  2. Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Eppendorf, Hamburg, Germany.

PMID: 29404394 PMCID: PMC5791865 DOI: 10.1080/23723556.2017.1396389

Abstract

Complex posttranslational modifications determine the effects of receptor-interacting protein kinase-1 (RIPK1) on cell survival and death. Studies from us and others have revealed a p38

Keywords: MK2; RIPK1; cell death; phosphorylation; signal transduction

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