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Zimmer M, Bista P, Benson EL, et al. CAT-2003: A novel sterol regulatory element-binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3-Leiden mice. Hepatol Commun. 2017;1(4):311-325doi: 10.1002/hep4.1042.
Zimmer, M., Bista, P., Benson, E. L., Lee, D. Y., Liu, F., Picarella, D., Vega, R. B., Vu, C. B., Yeager, M., Ding, M., Liang, G., Horton, J. D., Kleemann, R., Kooistra, T., Morrison, M. C., Wielinga, P. Y., Milne, J. C., Jirousek, M. R., & Nichols, A. J. (2017). CAT-2003: A novel sterol regulatory element-binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3-Leiden mice. Hepatology communications, 1(4), 311-325. https://doi.org/10.1002/hep4.1042
Zimmer, Michael, et al. "CAT-2003: A novel sterol regulatory element-binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3-Leiden mice." Hepatology communications vol. 1,4 (2017): 311-325. doi: https://doi.org/10.1002/hep4.1042
Zimmer M, Bista P, Benson EL, Lee DY, Liu F, Picarella D, Vega RB, Vu CB, Yeager M, Ding M, Liang G, Horton JD, Kleemann R, Kooistra T, Morrison MC, Wielinga PY, Milne JC, Jirousek MR, Nichols AJ. CAT-2003: A novel sterol regulatory element-binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3-Leiden mice. Hepatol Commun. 2017 May 12;1(4):311-325. doi: 10.1002/hep4.1042. eCollection 2017 Jun. PMID: 29404461; PMCID: PMC5721391.
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Hepatol Commun. 2017 May 12;1(4):311-325. doi: 10.1002/hep4.1042. eCollection 2017 Jun.

CAT-2003: A novel sterol regulatory element-binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3-Leiden mice.

Hepatology communications

Michael Zimmer, Pradeep Bista, Ericka L Benson, Diana Y Lee, Feng Liu, Dominic Picarella, Rick B Vega, Chi B Vu, Maisy Yeager, Min Ding, Guosheng Liang, Jay D Horton, Robert Kleemann, Teake Kooistra, Martine C Morrison, Peter Y Wielinga, Jill C Milne, Michael R Jirousek, Andrew J Nichols

Affiliations

  1. Catabasis Pharmaceuticals Cambridge MA.
  2. Department of Molecular Genetics University of Texas Southwestern Medical Center at Dallas Dallas TX.
  3. Department of Internal Medicine University of Texas Southwestern Medical Center at Dallas Dallas TX.
  4. Center for Human Nutrition University of Texas Southwestern Medical Center at Dallas Dallas TX.
  5. Netherlands Organization for Applied Scientific Research, Department of Metabolic Health Research Leiden the Netherlands.

PMID: 29404461 PMCID: PMC5721391 DOI: 10.1002/hep4.1042

Abstract

CAT-2003 is a novel conjugate of eicosapentaenoic acid (EPA) and niacin designed to be hydrolyzed by fatty acid amide hydrolase to release EPA inside cells at the endoplasmic reticulum. In cultured liver cells, CAT-2003 blocked the maturation of sterol regulatory element-binding protein (SREBP)-1 and SREBP-2 proteins and decreased the expression of multiple SREBP target genes, including

References

  1. Hepatology. 2015 Jan;61(1):108-18 - PubMed
  2. J Nutr Biochem. 2003 Jun;14(6):298-305 - PubMed
  3. J Clin Invest. 2006 Nov;116(11):2995-3005 - PubMed
  4. J Biol Chem. 1993 May 15;268(14):10540-5 - PubMed
  5. J Lipid Res. 2008 Feb;49(2):394-8 - PubMed
  6. Nat Med. 2003 Mar;9(3):352-5 - PubMed
  7. J Biol Chem. 2004 Dec 10;279(50):52772-80 - PubMed
  8. PLoS One. 2010 Jan 21;5(1):e8817 - PubMed
  9. Hepatol Res. 2011 Jul;41(7):670-4 - PubMed
  10. Cell. 1999 Dec 23;99(7):703-12 - PubMed
  11. J Cell Physiol. 2015 Sep;230(9):2224-32 - PubMed
  12. World J Gastroenterol. 2013 Nov 7;19(41):6969-78 - PubMed
  13. Hepatology. 2003 Dec;38(6):1529-39 - PubMed
  14. Arterioscler Thromb Vasc Biol. 2007 Aug;27(8):1706-21 - PubMed
  15. Biochem Soc Trans. 2002 Nov;30(Pt 6):1091-5 - PubMed
  16. Am J Respir Cell Mol Biol. 2012 Sep;47(3):288-97 - PubMed
  17. Sci Transl Med. 2012 Aug 22;4(148):148ra115 - PubMed
  18. Hepatology. 2010 May;51(5):1820-32 - PubMed
  19. Atherosclerosis. 1991 Mar;87(1):87-90 - PubMed
  20. Am J Physiol Cell Physiol. 2007 Dec;293(6):C1773-8 - PubMed
  21. J Lipid Res. 2011 Feb;52(2):318-29 - PubMed
  22. J Biol Chem. 2005 Jul 15;280(28):26483-90 - PubMed
  23. PLoS One. 2014 Dec 23;9(12):e115922 - PubMed
  24. Int J Clin Exp Med. 2014 Aug 15;7(8):2129-36 - PubMed
  25. Hepatology. 2004 Dec;40(6):1387-95 - PubMed
  26. J Lipid Res. 2004 Oct;45(10):1835-45 - PubMed
  27. J Lipid Res. 2009 Apr;50 Suppl:S172-7 - PubMed
  28. Science. 2001 May 11;292(5519):1160-4 - PubMed
  29. N Engl J Med. 2012 Mar 22;366(12 ):1108-18 - PubMed
  30. J Hepatol. 2015 May;62(5):1180-6 - PubMed
  31. J Med Chem. 2016 Feb 11;59(3):1217-31 - PubMed
  32. J Lipid Res. 2009 Apr;50 Suppl:S15-27 - PubMed
  33. J Lipid Res. 2014 Oct;55(10):2103-12 - PubMed
  34. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1444-9 - PubMed
  35. J Biol Chem. 2001 Feb 9;276(6):4365-72 - PubMed
  36. Nature. 1996 Nov 7;384(6604):83-7 - PubMed
  37. Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15;306(4):G320-7 - PubMed
  38. Diabetes. 2013 Apr;62(4):1109-20 - PubMed
  39. Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2322-30 - PubMed
  40. Curr Atheroscler Rep. 2016 Apr;18(4):17 - PubMed
  41. Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):161-7 - PubMed
  42. JAMA. 2012 Dec 19;308(23 ):2497-506 - PubMed
  43. Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1454-9 - PubMed
  44. Biochem Pharmacol. 2010 Nov 15;80(10):1601-12 - PubMed
  45. Cell. 2010 Sep 3;142(5):687-98 - PubMed
  46. Atherosclerosis. 2014 Mar;233(1):149-56 - PubMed
  47. J Biol Chem. 2014 Jan 24;289(4):2148-56 - PubMed

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