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Hanselmann S, Wolter P, Malkmus J, et al. The microtubule-associated protein PRC1 is a potential therapeutic target for lung cancer. Oncotarget. 2017;9(4):4985-4997doi: 10.18632/oncotarget.23577.
Hanselmann, S., Wolter, P., Malkmus, J., & Gaubatz, S. (2018). The microtubule-associated protein PRC1 is a potential therapeutic target for lung cancer. Oncotarget, 9(4), 4985-4997. https://doi.org/10.18632/oncotarget.23577
Hanselmann, Steffen, et al. "The microtubule-associated protein PRC1 is a potential therapeutic target for lung cancer." Oncotarget vol. 9,4 (2018): 4985-4997. doi: https://doi.org/10.18632/oncotarget.23577
Hanselmann S, Wolter P, Malkmus J, Gaubatz S. The microtubule-associated protein PRC1 is a potential therapeutic target for lung cancer. Oncotarget. 2017 Dec 22;9(4):4985-4997. doi: 10.18632/oncotarget.23577. eCollection 2018 Jan 12. PMID: 29435157; PMCID: PMC5797028.
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Oncotarget. 2017 Dec 22;9(4):4985-4997. doi: 10.18632/oncotarget.23577. eCollection 2018 Jan 12.

The microtubule-associated protein PRC1 is a potential therapeutic target for lung cancer.

Oncotarget

Steffen Hanselmann, Patrick Wolter, Jonas Malkmus, Stefan Gaubatz

Affiliations

  1. Theodor Boveri Institute, Biocenter, University of Wuerzburg and Comprehensive Cancer Center Mainfranken, University of Wuerzburg, University of Wuerzburg, Wuerzburg, Germany.

PMID: 29435157 PMCID: PMC5797028 DOI: 10.18632/oncotarget.23577

Abstract

In this study, we investigated whether proteins that are involved in cytokinesis are potential targets for therapy of lung cancer. We find that the microtubule-associated protein PRC1 (protein required for cytokinesis 1), which plays a key role in organizing anti-parallel microtubule in the central spindle in cytokinesis, is overexpressed in lung cancer cell lines compared to normal cells. Increased expression of PRC1 is correlated with a poor prognosis of human lung adenocarcinoma patients. Lentiviral delivered, inducible RNAi of PRC1 demonstrated that proliferation of lung cancer cell lines strongly depends on PRC1. Significantly, we also show that PRC1 is required for tumorigenesis

Keywords: PRC1; lung adenocarcinoma; mitotic kinesins; therapeutic target

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

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