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Schmitz-Peiffer C. Anarchy in the UPR: A Ca. Biosci Rep. 2018;doi: 10.1042/BSR20170966.
Schmitz-Peiffer, C. (2018). Anarchy in the UPR: A Ca. Bioscience reports, . https://doi.org/10.1042/BSR20170966
Schmitz-Peiffer, Carsten. "Anarchy in the UPR: A Ca." Bioscience reports vol. (2018). doi: https://doi.org/10.1042/BSR20170966
Schmitz-Peiffer C. Anarchy in the UPR: A Ca. Biosci Rep. 2018 Feb 08; doi: 10.1042/BSR20170966. Epub 2018 Feb 08. PMID: 29439143; PMCID: PMC5857902.
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Biosci Rep. 2018 Feb 08; doi: 10.1042/BSR20170966. Epub 2018 Feb 08.

Anarchy in the UPR: A Ca.

Bioscience reports

Carsten Schmitz-Peiffer

Affiliations

  1. Diabetes and Metabolism Division, Garvan Institute of Medical Research, and St Vincents Clinical School, University of New South Wales, Darlinghurst, Sydney, 2010, Australia [email protected].

PMID: 29439143 PMCID: PMC5857902 DOI: 10.1042/BSR20170966

Abstract

Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in Western countries, and is linked to the development of liver cancer and Type 2 diabetes (T2D). It is strongly associated with obesity, but the dysregulation of liver lipid storage is not fully understood. Fatty acid oversupply to hepatocytes can establish a vicious cycle involving diminished protein folding, endoplasmic reticulum (ER) stress, insulin resistance and further lipogenesis. This commentary discusses the recent findings of Lai

©2018 The Author(s).

Keywords: ER stress; insulin resistance; lipogenesis; protein kinase C; steatosis

References

  1. J Lipid Res. 2008 Sep;49(9):2038-44 - PubMed
  2. Mol Endocrinol. 2016 Apr;30(4):417-28 - PubMed
  3. J Lipid Res. 2009 Apr;50 Suppl:S74-9 - PubMed
  4. Biosci Rep. 2017 Nov 23;37(6):null - PubMed
  5. Cell Metab. 2012 May 2;15(5):623-34 - PubMed
  6. J Biol Chem. 2012 Jan 20;287(4):2273-9 - PubMed
  7. Cell Metab. 2012 May 2;15(5):570-3 - PubMed
  8. Diabetologia. 2011 Jun;54(6):1447-56 - PubMed
  9. Cell Metab. 2008 Feb;7(2):95-6 - PubMed
  10. J Biol Chem. 2010 Dec 31;285(53):42115-29 - PubMed
  11. J Lipid Res. 2016 Aug;57(8):1329-38 - PubMed
  12. Cell Signal. 2010 Feb;22(2):274-84 - PubMed
  13. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19320-5 - PubMed
  14. J Clin Invest. 2011 Jun;121(6):2504-17 - PubMed
  15. Cell. 2010 Mar 19;140(6):900-17 - PubMed
  16. Cell Metab. 2014 Feb 4;19(2):331-43 - PubMed
  17. Biochem J. 2015 Mar 1;466(2):379-90 - PubMed
  18. J Biol Chem. 1985 Sep 5;260(19):10819-25 - PubMed
  19. Diabetologia. 2009 Dec;52(12):2616-20 - PubMed
  20. Nat Rev Endocrinol. 2017 Oct;13(10 ):572-587 - PubMed
  21. Nat Rev Endocrinol. 2016 Dec;12 (12 ):710-722 - PubMed
  22. Nat Med. 2004 Mar;10(3):248-54 - PubMed
  23. Traffic. 2009 Jun;10(6):673-90 - PubMed
  24. J Biol Chem. 2016 Mar 4;291(10 ):5185-98 - PubMed
  25. Nature. 2011 May 26;473(7348):528-31 - PubMed
  26. FEBS J. 2013 Nov;280(21):5371-83 - PubMed
  27. Gastroenterology. 2016 Jun;150(8):1778-85 - PubMed
  28. J Cell Sci. 2004 Jan 15;117(Pt 2):131-2 - PubMed
  29. J Biol Chem. 2010 Aug 13;285(33):25720-30 - PubMed
  30. Gen Physiol Biophys. 2009;28 Spec No Focus:F96-F103 - PubMed
  31. Proteomics. 2014 Nov;14(21-22):2578-87 - PubMed
  32. J Biol Chem. 2012 Nov 30;287(49):41446-57 - PubMed
  33. J Biol Chem. 2013 Sep 13;288(37):26569-82 - PubMed
  34. Nat Med. 2014 Dec;20(12):1427-35 - PubMed
  35. Cell Calcium. 2000 Mar;27(3):175-85 - PubMed
  36. Cell Metab. 2007 Jul;6(1):69-78 - PubMed

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